메뉴 건너뛰기




Volumn 34, Issue 4, 2014, Pages 767-775

Arginine metabolism in asthma

Author keywords

ADMA; Agmatine; Arginase; Arginine metabolism; Citrulline; Nitric oxide synthase; Ornithine; Polyamine

Indexed keywords

ARGINASE; ARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE; PROTEIN ARGININE METHYLTRANSFERASE; ANTIASTHMATIC AGENT; N,N-DIMETHYLARGININE;

EID: 84922291732     PISSN: 08898561     EISSN: 15578607     Source Type: Journal    
DOI: 10.1016/j.iac.2014.07.007     Document Type: Review
Times cited : (22)

References (47)
  • 1
    • 0033577861 scopus 로고    scopus 로고
    • Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma
    • De Sanctis G.T., MacLean J.A., Hamada K., et al. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. JExp Med 1999, 189:1621-1630.
    • (1999) JExp Med , vol.189 , pp. 1621-1630
    • De Sanctis, G.T.1    MacLean, J.A.2    Hamada, K.3
  • 2
    • 67049156045 scopus 로고    scopus 로고
    • Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma
    • North M.L., Khanna N., Marsden P.A., et al. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am J Physiol Lung Cell Mol Physiol 2009, 296:L911-L920.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296 , pp. L911-L920
    • North, M.L.1    Khanna, N.2    Marsden, P.A.3
  • 3
    • 0036016110 scopus 로고    scopus 로고
    • Increased arginase activity underlies allergen-induced deficiency of cnos-derived nitric oxide and airway hyperresponsiveness
    • Meurs H., McKay S., Maarsingh H., et al. Increased arginase activity underlies allergen-induced deficiency of cnos-derived nitric oxide and airway hyperresponsiveness. Br J Pharmacol 2002, 136:391-398.
    • (2002) Br J Pharmacol , vol.136 , pp. 391-398
    • Meurs, H.1    McKay, S.2    Maarsingh, H.3
  • 4
    • 0042243556 scopus 로고    scopus 로고
    • Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    • Zimmermann N., King N.E., Laporte J., et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. JClin Invest 2003, 111:1863-1874.
    • (2003) JClin Invest , vol.111 , pp. 1863-1874
    • Zimmermann, N.1    King, N.E.2    Laporte, J.3
  • 5
    • 80053411528 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine is increased in asthma
    • Scott J.A., North M.L., Rafii M., et al. Asymmetric dimethylarginine is increased in asthma. Am J Respir Crit Care Med 2011, 184:779-785.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 779-785
    • Scott, J.A.1    North, M.L.2    Rafii, M.3
  • 6
    • 84872551287 scopus 로고    scopus 로고
    • An association between l-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype
    • Holguin F., Comhair S.A., Hazen S.L., et al. An association between l-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med 2013, 187:153-159.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 153-159
    • Holguin, F.1    Comhair, S.A.2    Hazen, S.L.3
  • 7
    • 60849089926 scopus 로고    scopus 로고
    • From arginine methylation to adma: a novel mechanism with therapeutic potential in chronic lung diseases
    • Zakrzewicz D., Eickelberg O. From arginine methylation to adma: a novel mechanism with therapeutic potential in chronic lung diseases. BMC Pulm Med 2009, 9:5.
    • (2009) BMC Pulm Med , vol.9 , pp. 5
    • Zakrzewicz, D.1    Eickelberg, O.2
  • 8
    • 33749179022 scopus 로고    scopus 로고
    • Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases
    • Yildirim A.O., Bulau P., Zakrzewicz D., et al. Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am J Respir Cell Mol Biol 2006, 35:436-443.
    • (2006) Am J Respir Cell Mol Biol , vol.35 , pp. 436-443
    • Yildirim, A.O.1    Bulau, P.2    Zakrzewicz, D.3
  • 9
    • 33846219575 scopus 로고    scopus 로고
    • Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of adma
    • Bulau P., Zakrzewicz D., Kitowska K., et al. Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of adma. Am J Physiol Lung Cell Mol Physiol 2007, 292:L18-L24.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L18-L24
    • Bulau, P.1    Zakrzewicz, D.2    Kitowska, K.3
  • 10
    • 73949119562 scopus 로고    scopus 로고
    • Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs
    • Ahmad T., Mabalirajan U., Ghosh B., et al. Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs. Am J Respir Cell Mol Biol 2010, 42:3-8.
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 3-8
    • Ahmad, T.1    Mabalirajan, U.2    Ghosh, B.3
  • 11
    • 79953733007 scopus 로고    scopus 로고
    • Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma
    • Ahmad T., Mabalirajan U., Sharma A., et al. Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. Am J Respir Cell Mol Biol 2011, 44:531-539.
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 531-539
    • Ahmad, T.1    Mabalirajan, U.2    Sharma, A.3
  • 12
    • 80053210845 scopus 로고    scopus 로고
    • Expression of protein arginine n-methyltransferases in e3 rat models of acute asthma
    • [Chinese]
    • Sun Q.Z., Jiao F.F., Yang X.D., et al. Expression of protein arginine n-methyltransferases in e3 rat models of acute asthma. Nan Fang Yi Ke Da Xue Xue Bao 2010, 30:716-719. [in Chinese].
    • (2010) Nan Fang Yi Ke Da Xue Xue Bao , vol.30 , pp. 716-719
    • Sun, Q.Z.1    Jiao, F.F.2    Yang, X.D.3
  • 13
    • 84859412916 scopus 로고    scopus 로고
    • Upregulated protein arginine methyltransferase 1 by il-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats
    • Sun Q., Yang X., Zhong B., et al. Upregulated protein arginine methyltransferase 1 by il-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats. JImmunol 2012, 188:3506-3512.
    • (2012) JImmunol , vol.188 , pp. 3506-3512
    • Sun, Q.1    Yang, X.2    Zhong, B.3
  • 14
    • 0031424947 scopus 로고    scopus 로고
    • Interference of l-arginine analogues with l-arginine transport mediated by the y+ carrier hcat-2B
    • Closs E.I., Basha F.Z., Habermeier A., et al. Interference of l-arginine analogues with l-arginine transport mediated by the y+ carrier hcat-2B. Nitric Oxide 1997, 1:65-73.
    • (1997) Nitric Oxide , vol.1 , pp. 65-73
    • Closs, E.I.1    Basha, F.Z.2    Habermeier, A.3
  • 15
    • 84864820728 scopus 로고    scopus 로고
    • Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (cat1)
    • Strobel J., Mieth M., Endress B., et al. Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (cat1). JMol Cell Cardiol 2012, 53:392-400.
    • (2012) JMol Cell Cardiol , vol.53 , pp. 392-400
    • Strobel, J.1    Mieth, M.2    Endress, B.3
  • 16
    • 34249706763 scopus 로고    scopus 로고
    • The L-arginine paradox: importance of the l-arginine/asymmetrical dimethylarginine ratio
    • Bode-Boger S.M., Scalera F., Ignarro L.J. The L-arginine paradox: importance of the l-arginine/asymmetrical dimethylarginine ratio. Pharmacol Ther 2007, 114:295-306.
    • (2007) Pharmacol Ther , vol.114 , pp. 295-306
    • Bode-Boger, S.M.1    Scalera, F.2    Ignarro, L.J.3
  • 17
    • 72149111666 scopus 로고    scopus 로고
    • Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production
    • Pope A.J., Karrupiah K., Kearns P.N., et al. Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production. JBiol Chem 2009, 284:35338-35347.
    • (2009) JBiol Chem , vol.284 , pp. 35338-35347
    • Pope, A.J.1    Karrupiah, K.2    Kearns, P.N.3
  • 18
    • 70350059137 scopus 로고    scopus 로고
    • Role of the prmt-ddah-adma axis in theregulation of endothelial nitric oxide production
    • Pope A.J., Karuppiah K., Cardounel A.J. Role of the prmt-ddah-adma axis in theregulation of endothelial nitric oxide production. Pharmacol Res 2009, 60:461-465.
    • (2009) Pharmacol Res , vol.60 , pp. 461-465
    • Pope, A.J.1    Karuppiah, K.2    Cardounel, A.J.3
  • 19
    • 78649810960 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma
    • Klein E., Weigel J., Buford M.C., et al. Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. Am J Physiol Lung Cell Mol Physiol 2010, 299:L816-L825.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299 , pp. L816-L825
    • Klein, E.1    Weigel, J.2    Buford, M.C.3
  • 20
    • 84897533412 scopus 로고    scopus 로고
    • Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma
    • Kinker K.G., Gibson A.M., Bass S.A., et al. Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma. PLoS One 2014, 9:e85148.
    • (2014) PLoS One , vol.9 , pp. e85148
    • Kinker, K.G.1    Gibson, A.M.2    Bass, S.A.3
  • 21
    • 84895519654 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase ii overexpression attenuates LPS-mediated lung leak in acute lung injury
    • Aggarwal S., Gross C.M., Kumar S., et al. Dimethylarginine dimethylaminohydrolase ii overexpression attenuates LPS-mediated lung leak in acute lung injury. Am J Respir Cell Mol Biol 2014, 50:614-625.
    • (2014) Am J Respir Cell Mol Biol , vol.50 , pp. 614-625
    • Aggarwal, S.1    Gross, C.M.2    Kumar, S.3
  • 22
    • 34247625981 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells
    • Wells S.M., Holian A. Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells. Am J Respir Cell Mol Biol 2007, 36:520-528.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 520-528
    • Wells, S.M.1    Holian, A.2
  • 23
    • 59149102060 scopus 로고    scopus 로고
    • Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice
    • Wells S.M., Buford M.C., Migliaccio C.T., et al. Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. Am J Respir Cell Mol Biol 2009, 40:179-188.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 179-188
    • Wells, S.M.1    Buford, M.C.2    Migliaccio, C.T.3
  • 24
    • 84881019818 scopus 로고    scopus 로고
    • Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma
    • North M.L., Grasemann H., Khanna N., et al. Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol 2013, 48:694-702.
    • (2013) Am J Respir Cell Mol Biol , vol.48 , pp. 694-702
    • North, M.L.1    Grasemann, H.2    Khanna, N.3
  • 25
    • 84881523559 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine in exhaled breath condensate and serum of children with asthma
    • Carraro S., Giordano G., Piacentini G., et al. Asymmetric dimethylarginine in exhaled breath condensate and serum of children with asthma. Chest 2013, 144:405-410.
    • (2013) Chest , vol.144 , pp. 405-410
    • Carraro, S.1    Giordano, G.2    Piacentini, G.3
  • 27
    • 84868089090 scopus 로고    scopus 로고
    • Adma, sdma, l-arginine and nitric oxide in allergic pediatric bronchial asthma
    • Riccioni G., Bucciarelli V., Verini M., et al. Adma, sdma, l-arginine and nitric oxide in allergic pediatric bronchial asthma. JBiol Regul Homeost Agents 2012, 26:561-566.
    • (2012) JBiol Regul Homeost Agents , vol.26 , pp. 561-566
    • Riccioni, G.1    Bucciarelli, V.2    Verini, M.3
  • 28
    • 84877093582 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and asthma: results from the childhood asthma prevention study
    • Lau E.M., Morgan P.E., Belousova E.G., et al. Asymmetric dimethylarginine and asthma: results from the childhood asthma prevention study. Eur Respir J 2013, 41:1234-1237.
    • (2013) Eur Respir J , vol.41 , pp. 1234-1237
    • Lau, E.M.1    Morgan, P.E.2    Belousova, E.G.3
  • 29
    • 84895917957 scopus 로고    scopus 로고
    • Acommon 16p11.2 inversion underlies the joint susceptibility to asthma and obesity
    • Gonzalez J.R., Caceres A., Esko T., et al. Acommon 16p11.2 inversion underlies the joint susceptibility to asthma and obesity. Am J Hum Genet 2014, 94:361-372.
    • (2014) Am J Hum Genet , vol.94 , pp. 361-372
    • Gonzalez, J.R.1    Caceres, A.2    Esko, T.3
  • 30
    • 84891889644 scopus 로고    scopus 로고
    • Interleukin-17-producing innate lymphoid cells and the nlrp3 inflammasome facilitate obesity-associated airway hyperreactivity
    • Kim H.Y., Lee H.J., Chang Y.J., et al. Interleukin-17-producing innate lymphoid cells and the nlrp3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med 2014, 20:54-61.
    • (2014) Nat Med , vol.20 , pp. 54-61
    • Kim, H.Y.1    Lee, H.J.2    Chang, Y.J.3
  • 31
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the severe asthma research program
    • Moore W.C., Meyers D.A., Wenzel S.E., National Heart Lung, Blood Institute's Severe Asthma Research Program, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med 2010, 181:315-323.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3
  • 32
  • 33
    • 84861008611 scopus 로고    scopus 로고
    • Cluster analysis of obesity and asthma phenotypes
    • Sutherland E.R., Goleva E., King T.S., Asthma Clinical Research Network, et al. Cluster analysis of obesity and asthma phenotypes. PLoS One 2012, 7:e36631.
    • (2012) PLoS One , vol.7 , pp. e36631
    • Sutherland, E.R.1    Goleva, E.2    King, T.S.3
  • 34
    • 34249669242 scopus 로고    scopus 로고
    • Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics
    • Komakula S., Khatri S., Mermis J., et al. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res 2007, 8:32.
    • (2007) Respir Res , vol.8 , pp. 32
    • Komakula, S.1    Khatri, S.2    Mermis, J.3
  • 35
    • 79957827092 scopus 로고    scopus 로고
    • Obesity and asthma: an association modified by age of asthma onset
    • Holguin F., Bleecker E.R., Busse W.W., et al. Obesity and asthma: an association modified by age of asthma onset. JAllergy Clin Immunol 2011, 127:1486-1493.e2.
    • (2011) JAllergy Clin Immunol , vol.127 , pp. 1486-1493.e2
    • Holguin, F.1    Bleecker, E.R.2    Busse, W.W.3
  • 36
    • 84922296555 scopus 로고    scopus 로고
    • Arginine and nitric oxide pathways in obesity-associated asthma
    • Holguin F. Arginine and nitric oxide pathways in obesity-associated asthma. JAllergy (Cairo) 2013, 2013:714595.
    • (2013) JAllergy (Cairo) , vol.2013 , pp. 714595
    • Holguin, F.1
  • 37
    • 84872568719 scopus 로고    scopus 로고
    • Clinical-biological phenotyping beyond inflammation in asthma delivers
    • Sterk P.J., Ricciardolo F.L. Clinical-biological phenotyping beyond inflammation in asthma delivers. Am J Respir Crit Care Med 2013, 187:117-118.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 117-118
    • Sterk, P.J.1    Ricciardolo, F.L.2
  • 38
    • 77649275723 scopus 로고    scopus 로고
    • Beneficial effects of high dose of l-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma
    • Mabalirajan U., Ahmad T., Leishangthem G.D., et al. Beneficial effects of high dose of l-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma. JAllergy Clin Immunol 2010, 125:626-635.
    • (2010) JAllergy Clin Immunol , vol.125 , pp. 626-635
    • Mabalirajan, U.1    Ahmad, T.2    Leishangthem, G.D.3
  • 39
    • 84882882270 scopus 로고    scopus 로고
    • Arandomized controlled trial of inhaled l-arginine in patients with cystic fibrosis
    • Grasemann H., Tullis E., Ratjen F. Arandomized controlled trial of inhaled l-arginine in patients with cystic fibrosis. JCyst Fibros 2013, 12:468-474.
    • (2013) JCyst Fibros , vol.12 , pp. 468-474
    • Grasemann, H.1    Tullis, E.2    Ratjen, F.3
  • 40
    • 79551589237 scopus 로고    scopus 로고
    • L-arginine supplementation and metabolism in asthma
    • Kenyon N.J., Last M., Bratt J.M., et al. L-arginine supplementation and metabolism in asthma. Pharmaceuticals 2011, 4:187-201.
    • (2011) Pharmaceuticals , vol.4 , pp. 187-201
    • Kenyon, N.J.1    Last, M.2    Bratt, J.M.3
  • 41
    • 84873662529 scopus 로고    scopus 로고
    • Improvement of ventricular function in systolic heart failure patients with oral l-citrulline supplementation
    • Balderas-Munoz K., Castillo-Martinez L., Orea-Tejeda A., et al. Improvement of ventricular function in systolic heart failure patients with oral l-citrulline supplementation. Cardiol J 2012, 19:612-617.
    • (2012) Cardiol J , vol.19 , pp. 612-617
    • Balderas-Munoz, K.1    Castillo-Martinez, L.2    Orea-Tejeda, A.3
  • 42
    • 84861536370 scopus 로고    scopus 로고
    • Citrulline a more suitable substrate than arginine to restore no production and the microcirculation during endotoxemia
    • Wijnands K.A., Vink H., Briede J.J., et al. Citrulline a more suitable substrate than arginine to restore no production and the microcirculation during endotoxemia. PLoS One 2012, 7:e37439.
    • (2012) PLoS One , vol.7 , pp. e37439
    • Wijnands, K.A.1    Vink, H.2    Briede, J.J.3
  • 43
    • 3142757008 scopus 로고    scopus 로고
    • Decreased arginine bioavailability and increased serum arginase activity in asthma
    • Morris C.R., Poljakovic M., Lavrisha L., et al. Decreased arginine bioavailability and increased serum arginase activity in asthma. Am J Respir Crit Care Med 2004, 170:148-153.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 148-153
    • Morris, C.R.1    Poljakovic, M.2    Lavrisha, L.3
  • 44
    • 79952152916 scopus 로고    scopus 로고
    • Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity
    • Sousse L.E., Yamamoto Y., Enkhbaatar P., et al. Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity. Shock 2011, 35:282-288.
    • (2011) Shock , vol.35 , pp. 282-288
    • Sousse, L.E.1    Yamamoto, Y.2    Enkhbaatar, P.3
  • 45
    • 0035661260 scopus 로고    scopus 로고
    • The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma
    • Tanaka H., Masuda T., Tokuoka S., et al. The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma. Inflamm Res 2001, 50:616-624.
    • (2001) Inflamm Res , vol.50 , pp. 616-624
    • Tanaka, H.1    Masuda, T.2    Tokuoka, S.3
  • 47
    • 78649245378 scopus 로고    scopus 로고
    • Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
    • Zeki A.A., Bratt J.M., Rabowsky M., et al. Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?. Transl Res 2010, 156:335-349.
    • (2010) Transl Res , vol.156 , pp. 335-349
    • Zeki, A.A.1    Bratt, J.M.2    Rabowsky, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.