Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats

Journal of Immunology

Volumn 188, Issue 7, 2012, Pages 3506-3512

  Sun, Qingzhu ^a,b   Yang, Xudong ^a,b   Zhong, Bo ^a,b   Jiao, Fangfang ^a   Li, Chenyan ^a,b   Li, Dongmin ^a,b   Lan, Xi ^a,b   Sun, Jian ^a,b   Lu, Shemin ^a,b  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE METHYLTRANSFERASE INHIBITOR 1; CHEMOKINE RECEPTOR CCR3; EOTAXIN; INTERLEUKIN 4; METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; PROTEIN ARGININE METHYLTRANSFERASE 1; PROTEIN ARGININE METHYLTRANSFERASE 2; PROTEIN ARGININE METHYLTRANSFERASE 3; PROTEIN ARGININE METHYLTRANSFERASE 4; PROTEIN ARGININE METHYLTRANSFERASE 5; PROTEIN ARGININE METHYLTRANSFERASE 6; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; EOSINOPHIL; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION; RNA INTERFERENCE; UPREGULATION;

ANIMALS; ANTIGENS; ASTHMA; CHEMOKINE CCL11; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; INTERLEUKIN-4; MALE; NAPHTHALENESULFONATES; OVALBUMIN; PROTEIN-ARGININE N-METHYLTRANSFERASES; PULMONARY EOSINOPHILIA; RATS; RECOMBINANT PROTEINS; RESPIRATORY SYSTEM; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPECIFIC PATHOGEN-FREE ORGANISMS; UREA;

EID: 84859412916     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102635     Document Type: Article

References (40)

1. Kay, A. B. 2005. The role of eosinophils in the pathogenesis of asthma. Trends Mol. Med. 11: 148-152.
2. Kay, A. B. 1991. Asthma and inflammation. J. Allergy Clin. Immunol. 87: 893-910.
3. Janson, C., and M. Herala. 1992. Blood eosinophil count as risk factor for relapse in acute asthma. Respir. Med. 86: 101-104.
4. Conroy, D. M., and T. J. Williams. 2001. Eotaxin and the attraction of eosinophils to the asthmatic lung. Respir. Res. 2: 150-156. (Pubitemid 34187921)
5. Richter, A., S. M. Puddicombe, J. L. Lordan, F. Bucchieri, S. J. Wilson, R. Djukanovic, G. Dent, S. T. Holgate, and D. E. Davies. 2001. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am. J. Respir. Cell Mol. Biol. 25: 385-391. (Pubitemid 32918922)
6. Banwell, M. E., N. S. Tolley, T. J. Williams, and T. J. Mitchell. 2002. Regulation of human eotaxin-3/CCL26 expression: modulation by cytokines and glucocorticoids. Cytokine 17: 317-323.
7. Fallon, P. G., H. E. Jolin, P. Smith, C. L. Emson, M. J. Townsend, R. Fallon, P. Smith, and A. N. J. McKenzie. 2002. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17: 7-17. (Pubitemid 34874614)
8. Sun, Q. Z., F. F. Jiao, X. D. Yang, B. Zhong, M. H. Jiang, G. L. Li, B. Lu, Y. Han, Q. L. Ning, F. J. Zhang, et al. 2010. Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma. Journal of Southern Medical University 30: 716-719.
9. Kakimoto, Y. 1971. Methylation of arginine and lysine residues of cerebral proteins. Biochim. Biophys. Acta 243: 31-37.
10. Bedford, M. T., and S. Richard. 2005. Arginine methylation an emerging regulator of protein function. Mol. Cell 18: 263-272. (Pubitemid 41350532)
11. Huang, S. M., M. Litt, and G. Felsenfeld. 2005. Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications. Genes Dev. 19: 1885-1893. (Pubitemid 41186989)
12. Strahl, B. D., S. D. Briggs, C. J. Brame, J. A. Caldwell, S. S. Koh, H. Ma, R. G. Cook, J. Shabanowitz, D. F. Hunt, M. R. Stallcup, and C. D. Allis. 2001. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr. Biol. 11: 996-1000. (Pubitemid 32589194)
13. Wang, H. B., Z. Q. Huang, L. Xia, Q. Feng, H. Erdjument-Bromage, B. D. Strahl, S. D. Briggs, C. D. Allis, J. M. Wong, P. Tempst, and Y. Zhang. 2001. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 293: 853-857. (Pubitemid 32743973)
14. Mowen, K. A., B. T. Schurter, J. W. Fathman, M. David, and L. H. Glimcher. 2004. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol. Cell 15: 559-571. (Pubitemid 39141783)
15. Parry, R. V., and S. G. Ward. 2010. Protein arginine methylation: a new handle on T lymphocytes? Trends Immunol. 31: 164-169.
16. Yang, X. D., Q. Z. Sun, M. B. R. Asim, X. G. Jiang, B. Zhong, M. Shahzad, F. J. Zhang, Y. Han, and S. M. Lu. 2010. Nitric oxide in both bronchoalveolar lavage fluid and serum is associated with pathogenesis and severity of antigen-induced pulmonary inflammation in rats. J. Asthma 47: 135-144.
17. Cheng, D. H., N. Yadav, R. W. King, M. S. Swanson, E. J. Weinstein, and M. T. Bedford. 2004. Small molecule regulators of protein arginine methyltransferases. J. Biol. Chem. 279: 23892-23899. (Pubitemid 38725246)
18. Sun, Q., X. Yang, M. B. Asim, F. Jiao, X. He, B. Zhong, D. Li, and S. Lu. 2011. Different challenge terms determine disease patterns of antigen-induced pulmonary inflammation in E3 rats. APMIS 119: 229-238.
19. Chen, Y., X. Xu, M. Sheng, X. Zhang, Q. Gu, and Z. Zheng. 2009. PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy. Exp. Eye Res. 89: 1028-1034.
20. Pope, A. J., K. Karuppiah, and A. J. Cardounel. 2009. Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production. Pharmacol. Res. 60: 461-465.
21. Liu, H., X. Qu, Z. Liang, W. Chen, W. Xia, and Y. Song. 2008. Variance of DDAH/PRMT/ADMA pathway in atrial fibrillation dogs. Biochem. Biophys. Res. Commun. 377: 884-888.
22. Zakrzewicz, D., and O. Eickelberg. 2009. From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases. BMC Pulm. Med. 9: 5.
23. Lee, D. Y., C. Teyssier, B. D. Strahl, and M. R. Stallcup. 2005. Role of protein methylation in regulation of transcription. Endocr. Rev. 26: 147-170.
24. Glimcher, L. H., and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14: 1693-1711. (Pubitemid 30602989)
25. Gangur, V., and J. J. Oppenheim. 2000. Are chemokines essential or secondary participants in allergic responses? Ann. Allergy Asthma Immunol. 84: 569-579, quiz 579-581.
26. Nicholson, T. B., T. Chen, and S. Richard. 2009. The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. Pharmacol. Res. 60: 466-474.
27. Bonham, K., S. Hemmers, Y. H. Lim, D. M. Hill, M. G. Finn, and K. A. Mowen. 2010. Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. FEBS J. 277: 2096-2108.
28. Webb, D. C., A. N. J. McKenzie, A. M. L. Koskinen, M. Yang, J. Mattes, and P. S. Foster. 2000. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. J. Immunol. 165: 108-113. (Pubitemid 30429497)
29. Dabbagh, K., K. Takeyama, H. M. Lee, I. F. Ueki, J. A. Lausier, and J. A. Nadel. 1999. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J. Immunol. 162: 6233-6237. (Pubitemid 29314987)
30. Nelms, K., A. D. Keegan, J. Zamorano, J. J. Ryan, and W. E. Paul. 1999. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17: 701-738. (Pubitemid 29241138)
31. Perkins, C., N. Yanase, G. Smulian, L. Gildea, T. Orekov, C. Potter, F. Brombacher, B. Aronow, M. Wills-Karp, and F. D. Finkelman. 2011. Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. J. Exp. Med. 208: 853-867.
32. White, S. R., L. D. Martin, R. Stern, B. Laxman, and B. A. Marroquin. 2010. Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 299: L681-L693.
33. Igarashi, H., K. Kuwahara, M. Yoshida, Y. Xing, K. Maeda, K. Nakajima, and N. Sakaguchi. 2009. GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells. Mol. Immunol. 46: 1031-1041.
34. Mowen, K. A., J. Tang, W. Zhu, B. T. Schurter, K. Shuai, H. R. Herschman, and M. David. 2001. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell 104: 731-741. (Pubitemid 32241023)
35. Komyod, W., U. M. Bauer, P. C. Heinrich, S. Haan, and I. Behrmann. 2005. Are STATS arginine-methylated? J. Biol. Chem. 280: 21700-21705. (Pubitemid 40834298)
36. Matsukura, S., C. Stellato, S. N. Georas, V. Casolaro, J. R. Plitt, K. Miura, S. Kurosawa, U. Schindler, and R. P. Schleimer. 2001. Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. Am. J. Respir. Cell Mol. Biol. 24: 755-761. (Pubitemid 32550599)
37. Rothenberg, M. E., J. A. MacLean, E. Pearlman, A. D. Luster, and P. Leder. 1997. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J. Exp. Med. 185: 785-790. (Pubitemid 27098162)
38. Dixon, H., C. Blanchard, M. L. Deschoolmeester, N. C. Yuill, J. W. Christie, M. E. Rothenberg, and K. J. Else. 2006. The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection. Eur. J. Immunol. 36: 1753-1763. (Pubitemid 44089042)
39. Rankin, S. M., D. M. Conroy, and T. J. Williams. 2000. Eotaxin and eosinophil recruitment: implications for human disease. Mol. Med. Today 6: 20-27. (Pubitemid 30010233)
40. Kodali, R. B., W. J. Kim, I. I. Galaria, C. Miller, A. D. Schecter, S. A. Lira, and M. B. Taubman. 2004. CCL11 (Eotaxin) induces CCR3-dependent smooth muscle cell migration. Arterioscler. Thromb. Vasc. Biol. 24: 1211-1216. (Pubitemid 38880010)