Increased arginase activity underlies allergen-induced deficiency of cNos-derived nitric oxide and airway hyperresponsiveness

British Journal of Pharmacology

Volumn 136, Issue 3, 2002, Pages 391-398

  Meurs, Herman ^a   McKay, Sue ^a   Maarsingh, Harm ^a   Hamer, Marco A M ^a   Macic, Lejla ^a   Molendijk, Niek ^a   Zaagsma, Johan ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Airway hyperresponsiveness; Allergic asthma; Arginase; Constitutive nitric oxide synthase; Early asthmatic reaction; Guinea pig; Methacholine; Nitric oxide; Tracheal perfusion

Indexed keywords

ALLERGEN; ARGINASE; ARGININE; CARBON 14; HISTAMINE; METHACHOLINE; N(G) HYDROXYARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OVALBUMIN; UREA; BRONCHOCONSTRICTING AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; METHACHOLINE CHLORIDE; N(OMEGA) HYDROXYNORARGININE; N(OMEGA)-HYDROXYNORARGININE;

ALLERGIC ASTHMA; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DISEASE MODEL; ENZYME ACTIVITY; ENZYME ASSAY; GUINEA PIG; INFLAMMATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROVOCATION TEST; TRACHEA; ANIMAL; DRUG ANTAGONISM; IMMUNOLOGY; IN VITRO STUDY; METABOLISM;

ALLERGENS; ANIMAL; ARGINASE; ARGININE; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTOR AGENTS; ENZYME INHIBITORS; GUINEA PIGS; IN VITRO; METHACHOLINE CHLORIDE; MODELS, ANIMAL; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; OVALBUMIN; SUPPORT, NON-U.S. GOV'T; TRACHEA; ANIMALS; NITRIC OXIDE SYNTHASE;

EID: 0036016110     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704725     Document Type: Article

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