Sigma-1 (σ1) receptor deficiency reduces β-amyloid25-35-induced hippocampal neuronal cell death and cognitive deficits through suppressing phosphorylation of the NMDA receptor NR2B

Neuropharmacology

Volumn 89, Issue , 2015, Pages 215-224

  Yin, Jun ^a   Sha, Sha ^a   Chen, Tingting ^a   Wang, Conghui ^a   Hong, Juan ^a   Jie, Pinghui ^a   Zhou, Rong ^a   Li, Lin ^a   Sokabe, Masahiro ^b   Chen, Ling ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer's disease (AD); Apoptosis; N methyl D aspartate receptor (NMDAr); Sigma 1 receptor ( 1R); Spatial memory Amyloid (A )

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; 4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; AMYLOID BETA PROTEIN[25-35]; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; SIGMA 1 OPIATE RECEPTOR; AMINO ACID RECEPTOR AFFECTING AGENT; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (25-35); N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYLASPARTIC ACID; NR2B NMDA RECEPTOR; PEPTIDE FRAGMENT; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; HIPPOCAMPAL CA1 REGION; LATENT PERIOD; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL; SPATIAL MEMORY; ANIMAL; APOPTOSIS; CELL DEATH; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; KNOCKOUT MOUSE; MAZE TEST; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REACTION TIME; TIME;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CELL DEATH; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGENTS; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; N-METHYLASPARTATE; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; SPATIAL MEMORY; TIME FACTORS;

EID: 84922276547     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.09.027     Document Type: Article

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