B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions

Molecular Immunology

Volumn 65, Issue 1, 2015, Pages 157-167

  Saini, Jasmine ^a   Hershberg, Uri ^a,b  

^a DREXEL UNIVERSITY   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Affinity maturation; B cells; Codon bias; Codon usage; Evolution; Somatic hypermutation

Indexed keywords

AMINO ACID; B LYMPHOCYTE RECEPTOR; B LYMPHOCYTE RECEPTOR VARIABLE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VACCINE; COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CODON USAGE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIGHT CHAIN; LONG TERM SURVIVAL; MUTATION RATE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOMATIC MUTATION; ADAPTIVE IMMUNITY; AGING; ANTIBODY AFFINITY; B LYMPHOCYTE; CYTOLOGY; GENETICS; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MUTATION; SOMATIC HYPERMUTATION;

ADAPTIVE IMMUNITY; AGING; ANTIBODY AFFINITY; B-LYMPHOCYTES; COMPLEMENTARITY DETERMINING REGIONS; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MUTATION; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 84922261187     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.01.001     Document Type: Article

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