Conditional disruption of miR17-92 cluster in collagen type I-producing osteoblasts results in reduced periosteal bone formation and bone anabolic response to exercise

Physiological Genomics

Volumn 47, Issue 2, 2015, Pages 33-43

  Mohan, Subburaman ^a,b   Wergedal, Jon E ^a,b   Das, Subhashri ^a   Kesavan, Chandrasekhar ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone formation; Conditional knockout; Mechanical strain; MicroRNA; Osteoblasts

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE ALPHA2; ELK3 PROTEIN; MICRORNA; MICRORNA 17-92; PROTEIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; MIRN17 MICRORNA, MOUSE; MIRN20 MICRORNA, MOUSE; MIRN92 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE DENSITOMETRY; BONE DENSITY; BONE GROWTH; BONE LENGTH; BONE MASS; BONE METABOLISM; BONE MINERAL; BONE MINERALIZATION; BONE STRENGTH; BONE STRESS; CARTILAGE CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; ELK3 GENE; EXERCISE; FEMALE; FEMUR; GENE; GENE CLUSTER; GENE DISRUPTION; GENE EXPRESSION; GENE TARGETING; GENOTYPE; KNOCKOUT MOUSE; LOXP SITE; MALE; METAPHYSIS; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PERIOSTEUM; PERIOSTIN GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RUNX2 GENE; TRABECULAR BONE; ANIMAL; BONE DEVELOPMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTIGENE FAMILY; PHYSIOLOGY; REPRODUCIBILITY; TIBIA; TRANSGENIC MOUSE;

MUS;

ANIMALS; COLLAGEN TYPE I; FEMALE; FEMUR; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICRORNAS; MULTIGENE FAMILY; OSTEOBLASTS; OSTEOGENESIS; PHYSICAL CONDITIONING, ANIMAL; REPRODUCIBILITY OF RESULTS; TIBIA;

EID: 84922256014     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00107.2014     Document Type: Article

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