Theobromine increases NAD+/Sirt-1 activity and protects the kidney under diabetic conditions

American Journal of Physiology - Renal Physiology

Volumn 308, Issue 3, 2015, Pages F209-F225

  Papadimitriou, Alexandros ^a   Silva, Kamila C ^a   Peixoto, Elisa B M I ^a   Borges, Cynthia M ^a   de Faria, Jacqueline M Lopes ^a   de Faria, José B Lopes ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

AMPK; Diabetic nephropathy; Extracellular matrix accumulation; Sirt 1 (sirtuin 1); Theobromine

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALBUMIN; COLLAGEN TYPE 4; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SIRTUIN 1; SMAD3 PROTEIN; SMALL INTERFERING RNA; THEOBROMINE; TRANSFORMING GROWTH FACTOR BETA1; PARP1 PROTEIN, RAT; REACTIVE OXYGEN METABOLITE;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG EFFECT; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE SILENCING; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; IN VIVO STUDY; MALE; MESANGIUM CELL; METABOLIC PARAMETERS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODEL; DRUG EFFECTS; KIDNEY; METABOLISM; PHYSIOLOGY;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; KIDNEY; MALE; NAD; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, INBRED SHR; REACTIVE OXYGEN SPECIES; SIRTUIN 1; THEOBROMINE;

EID: 84922246038     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00252.2014     Document Type: Article

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