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Volumn 229, Issue , 2015, Pages 1-8

Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet

Author keywords

Adipose tissue; Bardoxolone methyl; Inflammation; Obesity

Indexed keywords

BARDOXOLONE METHYL; I KAPPA B ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNCOUPLING PROTEIN 2; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; METHYL 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OATE; OLEANOLIC ACID;

EID: 84922245416     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.01.025     Document Type: Article
Times cited : (22)

References (73)
  • 1
    • 84922234129 scopus 로고    scopus 로고
    • High fat diet-induced obese and resistant mice differ in their serum leptin and hypothalamic neuronal activity
    • X.G. Xin, L.H. Storlien, S. Lin, X.F. Huang, High fat diet-induced obese and resistant mice differ in their serum leptin and hypothalamic neuronal activity, Society for Obesity Research, 1999
    • (1999) Society for Obesity Research
    • Xin, X.G.1    Storlien, L.H.2    Lin, S.3    Huang, X.F.4
  • 2
    • 84922245013 scopus 로고    scopus 로고
    • Influence of dietary fats on hypothalamic regulatory centers related to diet-induced obesity in mice
    • X.F. Huang, H.Q. Wang, L.H. Storlien. Influence of dietary fats on hypothalamic regulatory centers related to diet-induced obesity in mice, In: Society for Obesity Research, 1999.
    • (1999) Society for Obesity Research
    • Huang, X.F.1    Wang, H.Q.2    Storlien, L.H.3
  • 3
    • 77956013253 scopus 로고    scopus 로고
    • Minireview: Inflammation and obesity pathogenesis: The hypothalamus heats up
    • J.P. Thaler, and M.W. Schwartz Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up Endocrinology 151 2010 4109 4115
    • (2010) Endocrinology , vol.151 , pp. 4109-4115
    • Thaler, J.P.1    Schwartz, M.W.2
  • 4
    • 78650976239 scopus 로고    scopus 로고
    • High-fat diet increases NF-κB signaling in the prostate of reporter mice
    • E.V. Vykhovanets, E. Shankar, and O.V. Vykhovanets High-fat diet increases NF-κB signaling in the prostate of reporter mice Prostate 71 2010 147 156
    • (2010) Prostate , vol.71 , pp. 147-156
    • Vykhovanets, E.V.1    Shankar, E.2    Vykhovanets, O.V.3
  • 5
    • 79957482239 scopus 로고    scopus 로고
    • Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: Comparison to high-fat diet
    • B.P. Sampey, A.M. Vanhoose, and H.M. Winfield Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet Obesity 19 2011 1109 1117
    • (2011) Obesity , vol.19 , pp. 1109-1117
    • Sampey, B.P.1    Vanhoose, A.M.2    Winfield, H.M.3
  • 6
    • 0023601658 scopus 로고
    • Dietary fat and the regulation of energy intake in human subjects
    • L. Lissner, D.A. Levitsky, and B.J. Strupp Dietary fat and the regulation of energy intake in human subjects Am. J. Clin. Nutr. 46 1987 886 892
    • (1987) Am. J. Clin. Nutr. , vol.46 , pp. 886-892
    • Lissner, L.1    Levitsky, D.A.2    Strupp, B.J.3
  • 7
    • 0346880502 scopus 로고    scopus 로고
    • Molecular mechanisms of inflammation in obesity-linked insulin resistance
    • A. Marette Molecular mechanisms of inflammation in obesity-linked insulin resistance Int. J. Obes. Relat. Metab. Disord. 27 2003 S46 S48
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , pp. S46-S48
    • Marette, A.1
  • 8
    • 0034119138 scopus 로고    scopus 로고
    • The perils of portliness: Causes and consequences of visceral adiposity
    • C.T. Montague, and S. O'Rahilly The perils of portliness: causes and consequences of visceral adiposity Diabetes 49 2000 883 888
    • (2000) Diabetes , vol.49 , pp. 883-888
    • Montague, C.T.1    O'Rahilly, S.2
  • 9
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    • A.H. Mokdad, E.S. Ford, and B.A. Bowman Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 JAMA 289 2003 76 79
    • (2003) JAMA , vol.289 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3
  • 10
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • L. Fontana, J.C. Eagon, and M.E. Trujillo Visceral fat adipokine secretion is associated with systemic inflammation in obese humans Diabetes 56 2007 1010 1013
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3
  • 11
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • S.P. Weisberg, D. McCann, and M. Desai Obesity is associated with macrophage accumulation in adipose tissue J. Clin. Invest. 112 2003 1796 1808
    • (2003) J. Clin. Invest. , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3
  • 12
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • C.N. Lumeng, J.L. Bodzin, and A.R. Saltiel Obesity induces a phenotypic switch in adipose tissue macrophage polarization J. Clin. Invest. 117 2007 175 184
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 13
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • K.E. Wellen, and G. Hotamisligil Obesity-induced inflammatory changes in adipose tissue J. Clin. Invest. 112 2003 1785 1788
    • (2003) J. Clin. Invest. , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.2
  • 14
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • H. Xu, G.T. Barnes, and Q. Yang Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J. Clin. Invest. 112 2003 1821 1830
    • (2003) J. Clin. Invest. , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 15
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • J. Ye, Z. Gao, J. Yin, and Q. He Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice Am. J. Physiol. Endocrinol. Metab. 293 2007 E1118 E1128
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , pp. E1118-E1128
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 16
    • 84869184022 scopus 로고    scopus 로고
    • Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
    • N. Kawasaki, R. Asada, and A. Saito Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue Sci. Rep. 2 2012
    • (2012) Sci. Rep. , vol.2
    • Kawasaki, N.1    Asada, R.2    Saito, A.3
  • 18
    • 84899076566 scopus 로고    scopus 로고
    • Obesity and elevated blood pressure following repair of coarctation of the aorta
    • M. Smith-Parrish, S. Yu, and A. Rocchini Obesity and elevated blood pressure following repair of coarctation of the aorta J. Pediatr. 164 1074-1078 2014 e1071
    • (2014) J. Pediatr. , vol.164 , pp. e1071
    • Smith-Parrish, M.1    Yu, S.2    Rocchini, A.3
  • 19
    • 84903278455 scopus 로고    scopus 로고
    • Hypertensive subjects with type-2 diabetes, the sympathetic nervous system, and treatment implications
    • A.J.S. Coats, and J.M. Cruickshank Hypertensive subjects with type-2 diabetes, the sympathetic nervous system, and treatment implications Int. J. Cardiol. 174 2014 702 709
    • (2014) Int. J. Cardiol. , vol.174 , pp. 702-709
    • Coats, A.J.S.1    Cruickshank, J.M.2
  • 20
    • 85030434746 scopus 로고    scopus 로고
    • Increased oxidative stress in obesity and its impact on metabolic syndrome
    • S. Furukawa, T. Fujita, and M. Shimabukuro Increased oxidative stress in obesity and its impact on metabolic syndrome J. Clin. Invest. 114 2004 1752 1761
    • (2004) J. Clin. Invest. , vol.114 , pp. 1752-1761
    • Furukawa, S.1    Fujita, T.2    Shimabukuro, M.3
  • 22
    • 67650064559 scopus 로고    scopus 로고
    • Identification of signaling pathways involved in aberrant production of adipokines in adipocytes undergoing oxidative stress
    • B. Chen, J. Wei, and W. Wang Identification of signaling pathways involved in aberrant production of adipokines in adipocytes undergoing oxidative stress Arch. Med. Res. 40 2009 241 248
    • (2009) Arch. Med. Res. , vol.40 , pp. 241-248
    • Chen, B.1    Wei, J.2    Wang, W.3
  • 23
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
    • J.L. Evans, I.D. Goldfine, B.A. Maddux, and G.M. Grodsky Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes Endocr. Rev. 23 2002 599 622
    • (2002) Endocr. Rev. , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 24
    • 0037219409 scopus 로고    scopus 로고
    • Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?
    • J.L. Evans, I.D. Goldfine, B.A. Maddux, and G.M. Grodsky Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction? Diabetes 52 2003 1 8
    • (2003) Diabetes , vol.52 , pp. 1-8
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 25
    • 84855695314 scopus 로고    scopus 로고
    • High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB
    • E. Shankar, E.V. Vykhovanets, and O.V. Vykhovanets High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB Prostate 72 2012 233 243
    • (2012) Prostate , vol.72 , pp. 233-243
    • Shankar, E.1    Vykhovanets, E.V.2    Vykhovanets, O.V.3
  • 26
    • 34250863505 scopus 로고    scopus 로고
    • Mitogen-activated protein kases, inhibitory-κB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity
    • N. Bashan, Karina Dorfman, and Tanya Tarnovscki Mitogen-activated protein kases, inhibitory-κB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity Endocrinology 148 2007 2955 2962
    • (2007) Endocrinology , vol.148 , pp. 2955-2962
    • Bashan, N.1    Dorfman, K.2    Tarnovscki, T.3
  • 27
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • J. Hirosumi, G. Tuncman, and L. Chang A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 28
    • 56949098667 scopus 로고    scopus 로고
    • Sympathetic nervous system behavior in human obesity
    • K.P. Davy, and J.S. Orr Sympathetic nervous system behavior in human obesity Neurosci. Biobehav. Rev. 33 2009 116 124
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 116-124
    • Davy, K.P.1    Orr, J.S.2
  • 29
    • 0346034911 scopus 로고    scopus 로고
    • Sympathetic control of white adipose tissue in lean and obese humans
    • C. Dodt, P. Lönnroth, and J.P. Wellhöner Sympathetic control of white adipose tissue in lean and obese humans Acta Physiol. Scand. 177 2003 351 357
    • (2003) Acta Physiol. Scand. , vol.177 , pp. 351-357
    • Dodt, C.1    Lönnroth, P.2    Wellhöner, J.P.3
  • 30
    • 34548169165 scopus 로고    scopus 로고
    • Thematic review series: Adipocyte biology. Sympathetic and sensory innervation of white adipose tissue
    • T.J. Bartness, and C.K. Song Thematic review series: adipocyte biology. Sympathetic and sensory innervation of white adipose tissue J. Lipid Res. 48 2007 1655 1672
    • (2007) J. Lipid Res. , vol.48 , pp. 1655-1672
    • Bartness, T.J.1    Song, C.K.2
  • 31
    • 0028281432 scopus 로고
    • Impaired expression and functional activity of the β3- and β1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice
    • S. Collins, K.W. Daniel, and E.M. Rohlfs Impaired expression and functional activity of the β3- and β1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice Mol. Endocrinol. 8 1994 518
    • (1994) Mol. Endocrinol. , vol.8 , pp. 518
    • Collins, S.1    Daniel, K.W.2    Rohlfs, E.M.3
  • 32
    • 0033066802 scopus 로고    scopus 로고
    • Depressed expression of adipocyte β-adrenergic receptors is a common feature of congenital and dietary obesity in rodents
    • S. Collins, K.W. Daniel, and E.M. Rohlfs Depressed expression of adipocyte β-adrenergic receptors is a common feature of congenital and dietary obesity in rodents Int. J. Obes. 23 1999 669
    • (1999) Int. J. Obes. , vol.23 , pp. 669
    • Collins, S.1    Daniel, K.W.2    Rohlfs, E.M.3
  • 33
    • 64549162774 scopus 로고    scopus 로고
    • High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice
    • Y. Li, T. South, and M. Han High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice Brain Res. 1268 2009 181 189
    • (2009) Brain Res. , vol.1268 , pp. 181-189
    • Li, Y.1    South, T.2    Han, M.3
  • 34
    • 0029887455 scopus 로고    scopus 로고
    • Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist
    • I. Nagase, T. Yoshida, and K. Kumamoto Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist J. Clin. Invest. 97 1996 2898 2904
    • (1996) J. Clin. Invest. , vol.97 , pp. 2898-2904
    • Nagase, I.1    Yoshida, T.2    Kumamoto, K.3
  • 35
    • 78650355319 scopus 로고    scopus 로고
    • The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and leprdb/db mice
    • P.K. Saha, V.T. Reddy, and M. Konopleva The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and leprdb/db mice J. Biol. Chem. 285 2010 40581 40592
    • (2010) J. Biol. Chem. , vol.285 , pp. 40581-40592
    • Saha, P.K.1    Reddy, V.T.2    Konopleva, M.3
  • 37
    • 84922215625 scopus 로고    scopus 로고
    • Three stages of high fat diet-induced obesity and leptin resistance in C57 mice
    • S. Lin, T. Thomas, L. Storlien, et al, Three stages of high fat diet-induced obesity and leptin resistance in C57 mice, In: Society for Obesity Research, 1999.
    • (1999) Society for Obesity Research
    • Lin, S.1    Thomas, T.2    Storlien, L.3
  • 38
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57BI/6J mice
    • S. Lin, T.C. Thomas, L.H. Storlien, and X.F. Huang Development of high fat diet-induced obesity and leptin resistance in C57BI/6J mice Int. J. Obes. 24 2000 639 646
    • (2000) Int. J. Obes. , vol.24 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 39
    • 76549112866 scopus 로고    scopus 로고
    • Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice
    • K. Liby, R. Risingsong, and D.B. Royce Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice Cancer Prev. Res. 2 2009 1050 1058
    • (2009) Cancer Prev. Res. , vol.2 , pp. 1050-1058
    • Liby, K.1    Risingsong, R.2    Royce, D.B.3
  • 40
    • 84883196625 scopus 로고    scopus 로고
    • Teasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice
    • Y. Yu, Y. Wu, and A. Szabo Teasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice Endocrinology 154 2013 3130 3140
    • (2013) Endocrinology , vol.154 , pp. 3130-3140
    • Yu, Y.1    Wu, Y.2    Szabo, A.3
  • 41
    • 84859212663 scopus 로고    scopus 로고
    • Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life
    • T.M. du Bois, K.A. Newell, and X.-F. Huang Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life Eur. Neuropsychopharmacol. 22 2012 356 363
    • (2012) Eur. Neuropsychopharmacol. , vol.22 , pp. 356-363
    • Du Bois, T.M.1    Newell, K.A.2    Huang, X.-F.3
  • 42
    • 84895739540 scopus 로고    scopus 로고
    • Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway
    • J. Wu, X. Liu, and J. Fan Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway Toxicology 318 2014 22 31
    • (2014) Toxicology , vol.318 , pp. 22-31
    • Wu, J.1    Liu, X.2    Fan, J.3
  • 43
    • 84867160764 scopus 로고    scopus 로고
    • Bardoxolone methyl decreases megalin and activates Nrf2 in the kidney
    • S.A. Reisman, G.M. Chertow, and S. Hebbar Bardoxolone methyl decreases megalin and activates Nrf2 in the kidney J. Am. Soc. Nephrol. 2012
    • (2012) J. Am. Soc. Nephrol.
    • Reisman, S.A.1    Chertow, G.M.2    Hebbar, S.3
  • 44
    • 84896109181 scopus 로고    scopus 로고
    • Renoprotection and the bardoxolone methyl story - Is this the right way forward a novel view of renoprotection in CKD trials: A new classification scheme for renoprotective agents
    • M. Onuigbo Renoprotection and the bardoxolone methyl story - is this the right way forward a novel view of renoprotection in CKD trials: a new classification scheme for renoprotective agents Nephron Extra 3 2013 36 49
    • (2013) Nephron Extra , vol.3 , pp. 36-49
    • Onuigbo, M.1
  • 45
    • 0018834035 scopus 로고
    • Adipocyte size distribution in fafa rats during development
    • M.L. Kaplan, and P. Smith Adipocyte size distribution in fafa rats during development Metabolism 29 1980 333 339
    • (1980) Metabolism , vol.29 , pp. 333-339
    • Kaplan, M.L.1    Smith, P.2
  • 46
    • 0032429617 scopus 로고    scopus 로고
    • Association of fat cell size and paracrine growth factors in development of hyperplastic obesity
    • B.G. Marques, D.B. Hausman, and R.J. Martin Association of fat cell size and paracrine growth factors in development of hyperplastic obesity Am. J. Physiol. Regul. Integr. Comp. Physiol. 275 1998 R1898 R1908
    • (1998) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.275 , pp. R1898-R1908
    • Marques, B.G.1    Hausman, D.B.2    Martin, R.J.3
  • 47
    • 84879175433 scopus 로고    scopus 로고
    • Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of type 2 diabetes and obesity
    • M. Chin, C.-Y.I. Lee, and J.-C. Chuang Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of type 2 diabetes and obesity Am. J. of Physiol. Renal Physiol. 304 2013 F1438 F1446
    • (2013) Am. J. of Physiol. Renal Physiol. , vol.304 , pp. F1438-F1446
    • Chin, M.1    Lee, C.-Y.I.2    Chuang, J.-C.3
  • 48
    • 77950955698 scopus 로고    scopus 로고
    • Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet
    • C.L. de Melo, M.G.R. Queiroz, and S.G.C. Fonseca Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet Chem. Biol. Interact. 185 2010 59 65
    • (2010) Chem. Biol. Interact. , vol.185 , pp. 59-65
    • De Melo, C.L.1    Queiroz, M.G.R.2    Fonseca, S.G.C.3
  • 49
    • 84890946148 scopus 로고    scopus 로고
    • Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease
    • D. de Zeeuw, T. Akizawa, and P. Audhya Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease N. Engl. J. Med. 369 2013 2492 2503
    • (2013) N. Engl. J. Med. , vol.369 , pp. 2492-2503
    • De Zeeuw, D.1    Akizawa, T.2    Audhya, P.3
  • 50
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • G. Hotamisligil, N. Shargill, and B. Spiegelman Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance Science 259 1993 87
    • (1993) Science , vol.259 , pp. 87
    • Hotamisligil, G.1    Shargill, N.2    Spiegelman, B.3
  • 51
    • 84155165679 scopus 로고    scopus 로고
    • Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors
    • M.L. Batista, S.B. Peres, and M.E. McDonald Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors Cytokine 57 2012 9 16
    • (2012) Cytokine , vol.57 , pp. 9-16
    • Batista, M.L.1    Peres, S.B.2    McDonald, M.E.3
  • 52
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • S. Weisberg, D. McCann, and M. Desai Obesity is associated with macrophage accumulation in adipose tissue J. Clin. Invest. 112 2003 1796 1808
    • (2003) J. Clin. Invest. , vol.112 , pp. 1796-1808
    • Weisberg, S.1    McCann, D.2    Desai, M.3
  • 53
    • 26244448904 scopus 로고    scopus 로고
    • A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor α
    • T. Suganami, J. Nishida, and Y. Ogawa A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor α Arterioscler. Thromb. Vasc. Biol. 25 2005 2062 2068
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 2062-2068
    • Suganami, T.1    Nishida, J.2    Ogawa, Y.3
  • 54
    • 77954672503 scopus 로고    scopus 로고
    • Adipose tissue macrophages: Their role in adipose tissue remodeling
    • T. Suganami, and Y. Ogawa Adipose tissue macrophages: their role in adipose tissue remodeling J. Leukoc. Biol. 88 2010 33 39
    • (2010) J. Leukoc. Biol. , vol.88 , pp. 33-39
    • Suganami, T.1    Ogawa, Y.2
  • 55
    • 84872151878 scopus 로고    scopus 로고
    • The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer
    • K. Tran, R. Risingsong, and D.B. Royce The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer Carcinogenesis 34 2013 199 210
    • (2013) Carcinogenesis , vol.34 , pp. 199-210
    • Tran, K.1    Risingsong, R.2    Royce, D.B.3
  • 56
    • 84862557429 scopus 로고    scopus 로고
    • A phase i first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas
    • D.S. Hong, R. Kurzrock, and J.G. Supko A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas Clin. Cancer Res. 18 2012 3396 3406
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3396-3406
    • Hong, D.S.1    Kurzrock, R.2    Supko, J.G.3
  • 57
    • 84867910411 scopus 로고    scopus 로고
    • Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: Potential effects of bardoxolone methyl
    • P.A. McCullough, and S. Ali Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl Drug Des. Devel. Ther. 6 2012 141 149
    • (2012) Drug Des. Devel. Ther. , vol.6 , pp. 141-149
    • McCullough, P.A.1    Ali, S.2
  • 58
    • 84906699232 scopus 로고    scopus 로고
    • A derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner, lessens diabetes-associated atherosclerosis and improves diabetic kidney disease
    • S.M. Tan, A. Sharma, and N. Stefanovic A derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner, lessens diabetes-associated atherosclerosis and improves diabetic kidney disease Diabetes 2014
    • (2014) Diabetes
    • Tan, S.M.1    Sharma, A.2    Stefanovic, N.3
  • 59
    • 47149115165 scopus 로고    scopus 로고
    • Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity
    • N. Matsuzawa-Nagata, T. Takamura, and H. Ando Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity Metabolism 57 2008 1071 1077
    • (2008) Metabolism , vol.57 , pp. 1071-1077
    • Matsuzawa-Nagata, N.1    Takamura, T.2    Ando, H.3
  • 60
    • 13044287359 scopus 로고    scopus 로고
    • Meal-induced oxidative stress and low-density lipoprotein oxidation in diabetes: The possible role of hyperglycemia
    • A. Ceriello, N. Bortolotti, and E. Motz Meal-induced oxidative stress and low-density lipoprotein oxidation in diabetes: the possible role of hyperglycemia Metab. Clin. Exp. 48 1999 1503 1508
    • (1999) Metab. Clin. Exp. , vol.48 , pp. 1503-1508
    • Ceriello, A.1    Bortolotti, N.2    Motz, E.3
  • 61
    • 0034939115 scopus 로고    scopus 로고
    • The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
    • P. Rösen, P.P. Nawroth, and G. King The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society Diabetes/Metab. Res. Rev. 17 2001 189 212
    • (2001) Diabetes/Metab. Res. Rev. , vol.17 , pp. 189-212
    • Rösen, P.1    Nawroth, P.P.2    King, G.3
  • 62
    • 35048877043 scopus 로고    scopus 로고
    • Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity
    • H.K. Vincent, K.E. Innes, and K.R. Vincent Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity Diabetes Obes. Metab. 9 2007 813 839
    • (2007) Diabetes Obes. Metab. , vol.9 , pp. 813-839
    • Vincent, H.K.1    Innes, K.E.2    Vincent, K.R.3
  • 63
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • G. Sabio, M. Das, and A. Mora A stress signaling pathway in adipose tissue regulates hepatic insulin resistance Science 322 2008 1539 1543
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3
  • 64
    • 0029955623 scopus 로고    scopus 로고
    • Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases
    • Y.Y.C. Lo, J.M.S. Wong, and T.F. Cruz Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases J. Biol. Chem. 271 1996 15703 15707
    • (1996) J. Biol. Chem. , vol.271 , pp. 15703-15707
    • Lo, Y.Y.C.1    Wong, J.M.S.2    Cruz, T.F.3
  • 65
    • 80054884435 scopus 로고    scopus 로고
    • Bardoxolone methyl: A targeted antioxidant
    • A. Gupta, and A. Khaira Bardoxolone methyl: a targeted antioxidant Ren. Fail. 33 2011 1051
    • (2011) Ren. Fail. , vol.33 , pp. 1051
    • Gupta, A.1    Khaira, A.2
  • 66
    • 84866175152 scopus 로고    scopus 로고
    • Antioxidants in kidney diseases: The impact of bardoxolone methyl
    • J. Rojas-Rivera, A. Ortiz, and J. Egido Antioxidants in kidney diseases: the impact of bardoxolone methyl Int. J. Nephrol. 2012 2012 11
    • (2012) Int. J. Nephrol. , vol.2012 , pp. 11
    • Rojas-Rivera, J.1    Ortiz, A.2    Egido, J.3
  • 67
    • 19444367043 scopus 로고    scopus 로고
    • Regional-dependent increase of sympathetic innervation in rat white adipose tissue during prolonged fasting
    • A. Giordano, A. Frontini, and I. Murano Regional-dependent increase of sympathetic innervation in rat white adipose tissue during prolonged fasting J. Histochem. Cytochem. 53 2005 679 687
    • (2005) J. Histochem. Cytochem. , vol.53 , pp. 679-687
    • Giordano, A.1    Frontini, A.2    Murano, I.3
  • 70
    • 69749094930 scopus 로고    scopus 로고
    • Diet-induced obese mice are leptin insufficient after weight reduction
    • H. Shi, S. Akunuru, and J.C. Bierman Diet-induced obese mice are leptin insufficient after weight reduction Obesity 17 2009 1702 1709
    • (2009) Obesity , vol.17 , pp. 1702-1709
    • Shi, H.1    Akunuru, S.2    Bierman, J.C.3
  • 71
    • 0032584237 scopus 로고    scopus 로고
    • Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice
    • R.S. Surwit, S. Wang, and A.E. Petro Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice Proc. Natl. Acad. Sci. U.S.A. 95 1998 4061 4065
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 4061-4065
    • Surwit, R.S.1    Wang, S.2    Petro, A.E.3
  • 72
    • 84874413612 scopus 로고    scopus 로고
    • β-Adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure
    • S. Collins β-Adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure Front. Endocrinol. 3 2012
    • (2012) Front. Endocrinol. , vol.3
    • Collins, S.1
  • 73
    • 33845756267 scopus 로고    scopus 로고
    • Sustained phosphorylation of tyrosine hydroxylase at serine 40: A novel mechanism for maintenance of catecholamine synthesis
    • L. Bobrovskaya, C. Gilligan, and E.K. Bolster Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis J. Neurochem. 100 2007 479 489
    • (2007) J. Neurochem. , vol.100 , pp. 479-489
    • Bobrovskaya, L.1    Gilligan, C.2    Bolster, E.K.3


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