Enhanced blood-brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system

Biomaterials

Volumn 37, Issue , 2015, Pages 345-352

  Yao, Hui ^a   Wang, Kaiyuan ^b   Wang, Yi ^a   Wang, Shanshan ^a   Li, Jianfeng ^a   Lou, Jinning ^c   Ye, Liya ^c   Yan, Xueying ^b   Lu, Weiyue ^a   Huang, Rongqin ^a  

^a FUDAN UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^c BEIJING HOSPITAL   (China)

Author keywords

Blood brain barrier; Cell penetrating peptide; Gene therapy; Glioma targeting

Indexed keywords

AMINO ACIDS; BLOOD; CELL DEATH; GENE ENCODING; GENE EXPRESSION; GENE TRANSFER; MOLECULAR BIOLOGY; PEPTIDES; TUMORS;

BLOOD-BRAIN BARRIER; CELL-PENETRATING PEPTIDE; GENE DELIVERY SYSTEMS; GLIOMA-TARGETING; INTRAVENOUS ADMINISTRATION; MECHANISM STUDIES; NANOPARTICLE (NPS); THERAPEUTIC GENES;

GENE THERAPY;

ANTINEOPLASTIC AGENT; INHIBITOR OF GROWTH 4; LIM KINASE; LIM KINASE 2; MACROGOL; NANOPARTICLE; PLASMID DNA; POLYLYSINE; POLYLYSINE POLYETHYLENEGLYCOL LIM KINASE 2 NUCLEOLAR TRANSLOCATION SIGNAL PEPTIDE DNA; PROTEIN; SODIUM CHLORIDE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; 1,1'-((4,4,7,7-TETRAMETHYL)-4,7-DIAZAUNDECAMETHYLENE)BIS-4-(3-METHYL-2,3-DIHYDRO(BENZO-1,3-OXAZOLE)-2-METHYLIDENE)QUINOLINIUM; BENZOXAZOLE DERIVATIVE; PEPTIDE; QUINOLINE DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CANCER GENE THERAPY; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE VECTOR; GLIOMA; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PINOCYTOSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SURVIVAL TIME; THERAPY EFFECT; TUMOR LOCALIZATION; ANIMAL; BRAIN NEOPLASMS; CELL DEATH; CELL MEMBRANE PERMEABILITY; CHEMISTRY; DRUG EFFECTS; GENE TRANSFER; METABOLISM; NUDE MOUSE; PATHOLOGY; SURVIVAL; TUMOR CELL LINE;

MUS;

ANIMALS; APOPTOSIS; BENZOXAZOLES; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GLIOMA; HUMANS; MALE; MICE, NUDE; NANOPARTICLES; PEPTIDES; QUINOLINIUM COMPOUNDS; SURVIVAL ANALYSIS;

EID: 84922244697     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.034     Document Type: Article

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