Nucleolar localization signals of LIM kinase 2 function as a cell-penetrating peptide

Protein and Peptide Letters

Volumn 17, Issue 12, 2010, Pages 1480-1488

  Kobayashi, Nahoko ^a,b   Niwa, Mikio ^a   Yang, Hao ^b   Yoshida, Tetsuhiko ^a,b  

^a Base Technology Center   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Blood brain barrier (BBB); Cell penetrating peptides (CPPs); Drug delivery system (DDS).; LIM Kinase 2 (LIMK2); Nucleolar localization signal (NoLS); Protein transduction domain (PTD)

Indexed keywords

IPS;

EID: 78650672128     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929866511009011480     Document Type: Article

References (27)

1. Sebbage, V. Cell-penetrating peptides and their therapeutic applications. Bioscience Horizons, 2009, 2(1), 64-72.
2. Teesalu, T.; Sugahara, K.N.; Kotamraju, V.R.; Ruoslahti, E. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc. Natl. Acad. Sci. U. S. A., 2009, 706(38), 16157-16162.
3. Dietz, G.P.; Kilic, E.; Bähr, M. Inhibition of neuronal apoptosis in vitro and in vivo using TAT-mediated protein transduction. Mol. Cell. Neurosci., 2002, 27(1), 29-37.
4. Dietz, G.P.; Bähr, M. Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol. Cell Neurosci., 2004, 27(2), 85-131.
5. Langel, U. Handbook of Cell-penetrating peptides, 2nd ed.; CRC/Taylor & Francis: Boca Raton, FL, 2007.
6. Frankel, A.D.; Pabo, C.O. Cellular uptake of the tat protein from human immunodeficiency virus. Cell, 1988, 55(6), 1189-1193.
7. Green, M.; Loewenstein, P.M. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell, 1988, 55(6), 1179-1188.
8. Joliot, A.; Pernelle, C.; Deagostini-Bazin, H.; Prochiantz, A. An-tennapedia homeobox peptide regulates neural morphogenesis. Proc. Natl. Acad. Sci. U. S. A., 1991, 88(5), 1864-1868.
9. Fischer, R.; Fotin-Mleczek, M.; Hufnagel, H.; Brock, R. Break on through to the other side-biophysics and cell biology shed light on cell-penetrating peptides. Chembiochem, 2005, 6(12), 2126-2142.
10. Richard, J.P.; Melikov, K.; Vives, E.; Ramos, C.; Verbeure, B.; Gait, M.J.; Chernomordik, L.V.; Lebleu, B. Cell-penetrating pep-tides. A reevaluation of the mechanism of cellular uptake. J. Biol. Chem., 2003, 278(1), 585-590.
11. Koppelhus, U.; Awasthi, S.K.; Zachar, V.; Holst, H.U.; Ebbesen, P.; Nielsen, P.E. Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates. Antisense Nucleic Acid Drug Dev., 2002, 72(2), 51-63.
12. Silhol, M.; Tyagi, M.; Giacca, M.; Lebleu, B.; and Vives, E. Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat. Eur. J. Biochem., 2002, 269(2), 494-501.
13. Nagata, K.; Ohashi, K.; Yang, N.; Mizuno, K. The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1. Biochem. J., 1999, 343(1), 99-105.
14. Kadrmas, J.L.; Beckerle, M.C. The LIM domain: from the cy-toskeleton to the nucleus. Nat. Rev. Mol. Cell Biol., 2004, 5(11), 920-931.
15. Sumi, T.; Matsumoto, K.; Nakamura, T. Specific activation of LIM kinase 2 via Phosphorylation of threonine 505 by Rock, a Rho-dependent protein kinase. J. Biol. Chem., 2001, 276(1), 670-676.
16. Po'uha, S.T.; Shum, M.S.; Goebel, A.; Bernard, O.; Kavallaris, M. LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs. Oncogene, 2010, 29(4), 597-607.
17. Amano, T.; Tanabe, K.; Eto, T.; Narumiya, S.; Mizuno, K. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem. J., 2001, 554(1), 149-159.
18. Emmott, E.; Hiscox, J.A. Nucleolar targeting: the hub of the matter. EMBO Rep., 2009, 70(3), 231-238.
19. Goyal, P.; Pandey, D.; Siess. W. Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. J. Biol. Chem., 2006, 287(35), 25223-25230.
20. Takahashi, K.; Tanabe, K.; Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.; Yamanaka, S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 2007, 757(5), 861-872.
21. Yamazaki, Y.; Kanno, H.; Maeda, K.; Yoshida, T.; Kobayashi, N.; Kubo, A.; Yamaguchi, Y.; Saito, T. Engrafted VHL peptide-delivered bone marrow stromal cells promote spinal cord repair in rats. Neuroreport, 2010, 27(4), 287-292.
22. Kubo, A.; Yoshida, T.; Kobayashi, N.; Yokoyama, T.; Mimura, T.; Nishiguchi, T.; Higashida, T.; Yamamoto, I.; Kanno, H. Efficient generation of dopamine neuron-like cells from skin-derived precur-sors with a synthetic peptide derived from von Hippel-Lindau protein. Stem Cells Dev., 2009, 78(10), 1523-1532.
23. Rout, M.P.; Aitchison, J.D.; Magnasco, M.O.; Chait, B.T. Virtual gating and nuclear transport: the hole picture. Trends Cell Biol., 2003, 75(12), 622-628.
24. Kilic, E.; Kilic, U.; Hermann, D.M. TAT-GDNF in neurodegeneration and ischemic stroke. CNS Drug Rev., 2005, 77(4), 369-378.
25. Spencer, B.J.; Verma, I.M. Targeted delivery of proteins across the blood-brain barrier. Proc Natl. Acad. Sci. U. S. A., 2007, 104(18), 7594-7599.
26. Schwarze, S.R.; Ho, A.; Vocero-Akbani, A.; Dowdy, S.F. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science, 1999, 285(5433), 1569-1572.
27. Sarantseva1, S.V.; Bolshakova1, O.I.; Timoshenko, S.I.; Kolobov, A.A.; Vitek, M.P.; Schwarzman1, A.L. Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila melanogaster. Biochem. (Moscow) Supplemental Series B Biomed. Chem., 2009, 3(2), 149-155.