Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 2, 2015, Pages 738-750

  Shetty, Rohit ^a   Ghosh, Anuprita ^a   Lim, Rayne R ^b   Subramani, Murali ^a   Mihir, Krina ^a   Reshma, A R ^a   Ranganath, Ashwini ^a   Nagaraj, Sriharsha ^a   Nuijts, Rudy M M A ^c   Beuerman, Roger ^b   Shetty, Reshma ^a   Das, Debashish ^a   Chaurasia, Shyam S ^b,d,e   Sinha Roy, Abhijit ^a   Ghosh, Arkasubhra ^a,b  

^a Narayana Health City   (India)

^b SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cornea; Cyclosporine A; Ectasia; Epithelial cells; IL6; Keratoconus; MMP9; TNF

Indexed keywords

COLLAGEN; COLLAGEN 1A1; COLLAGEN 4A1; COMPLEMENTARY DNA; CYCLOSPORIN A; GELATINASE B; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLOSPORIN; CYTOKINE; ENZYME INHIBITOR; RNA;

ADULT; ARTICLE; CONTROLLED STUDY; CORNEA CELL; CORNEA CURVATURE; CORNEA THICKNESS; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE IRRITATION; EYE PAIN; FEMALE; HUMAN; KERATOCONUS; KERATOMETRY; LACRIMAL FLUID; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUESTIONNAIRE; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TEAR FILM; UPREGULATION; BIOSYNTHESIS; CELL CULTURE; CORNEA EPITHELIUM; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; CELLS, CULTURED; CORNEAL TOPOGRAPHY; CYCLOSPORINE; CYTOKINES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIUM, CORNEAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; KERATOCONUS; MALE; MATRIX METALLOPROTEINASE 9; REAL-TIME POLYMERASE CHAIN REACTION; RNA; TEARS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84922236825     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-14831     Document Type: Article

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