Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis

Acta Pharmacologica Sinica

Volumn 28, Issue 8, 2007, Pages 1116-1122

  Tang, Chao ^a   Wu, An Hua ^a   Xue, Hong Li ^b   Wang, Yun Jie ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

Brain microvascular endothelial cells; Endothelin 1; Tanshinone IIA; TNF

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; MESSENGER RNA; TANSHINONE; TANSHINONE IIA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME IMMUNOASSAY; ENZYME REPRESSION; ENZYME SYNTHESIS; GENE EXPRESSION; NONHUMAN; PROTEIN BINDING; PROTEIN SECRETION; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIN-1; METALLOENDOPEPTIDASES; PHENANTHRENES; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34547561756     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00598.x     Document Type: Article

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