Epirubicin potentiates recombinant adeno-associated virus type 2/5-mediated TRAIL expression in fibroblast-like synoviocytes and augments the antiarthritic effects of rAAV2/5-TRAIL

Arthritis and Rheumatism

Volumn 64, Issue 5, 2012, Pages 1345-1354

  Shi, Juan ^a   Diao, Zhijuan ^a   Zhou, Jiansuo ^a   Zhu, Jieqing ^a   Yuan, Haiqin ^a   You, Xin ^b   Liu, Yanxin ^a   Zheng, Dexian ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; DEATH RECEPTOR 4; DEATH RECEPTOR 5; EPIRUBICIN; FLICE INHIBITORY PROTEIN; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADENOVIRUS 2; ADENOVIRUS 5; ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTHRITIS; ARTICLE; BONE EROSION; CARTILAGE DEGENERATION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DISEASE SEVERITY; DRUG SENSITIVITY; FIBROBLAST; GENE DOSAGE; GENE EXPRESSION; GENE THERAPY; HISTOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATORY CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNOVIOCYTE; TISSUE DISTRIBUTION; TRANSGENE; VIRUS GENOME;

ADENOVIRIDAE; ADULT; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, VIRAL; ARTHRITIS, EXPERIMENTAL; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; EPIRUBICIN; FEMALE; FIBROBLASTS; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; HUMANS; MALE; MICE; MICE, INBRED DBA; MIDDLE AGED; RECOMBINANT PROTEINS; SYNOVIAL MEMBRANE; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84860442663     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.33492     Document Type: Article

References (30)

1. Firestein GS,. Evolving concepts of rheumatoid arthritis. Nature 2003; 423: 356-61.
2. Firestein GS,. Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or transformed aggressors? [review]. Arthritis Rheum 1996; 39: 1781-90.
3. Okamoto K, Asahara H, Kobayashi T, Matsuno H, Hasunuma T, Kobata T, et al. Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Ther 1998; 5: 331-8.
4. Yao Q, Wang S, Glorioso JC, Evans CH, Robbins PD, Ghivizzani SC, et al. Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation. Mol Ther 2001; 3: 901-10.
5. Cha HS, Rosengren S, Boyle DL, Firestein GS,. PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis Rheum 2006; 54: 587-92.
6. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3: 673-82.
7. Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999; 104: 155-62.
8. Ichikawa K, Liu W, Zhao L, Wang Z, Liu D, Ohtsuka T, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999; 5: 157-63.
9. Ichikawa K, Liu W, Fleck M, Zhang H, Zhao L, Ohtsuka T, et al. TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol 2003; 171: 1061-9.
10. Yao Q, Seol DW, Mi Z, Robbins PD,. Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis. Arthritis Res Ther 2006; 8: R16.
11. Li W, Liu Z, Zhuang G, Yin P, Tao H, Qiu J, et al. Anti-DR5 mAb ameliorate adjuvant arthritis rats through inducing synovial cells. Exp Biol Med (Maywood) 2009; 234: 1468-76.
12. Song K, Chen Y, Goke R, Wilmen A, Seidel C, Goke A, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. J Exp Med 2000; 191: 1095-104.
13. Liu Z, Xu X, Hsu HC, Tousson A, Yang PA, Wu Q, et al. CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. J Clin Invest 2003; 112: 1332-41.
14. -/- mice. Nat Immunol 2003; 4: 255-60.
15. Martinez-Lorenzo MJ, Anel A, Saez-Gutierrez B, Royo-Canas M, Bosque A, Alava MA, et al. Rheumatoid synovial fluid T cells are sensitive to APO2L/TRAIL. Clin Immunol 2007; 122: 28-40.
16. Morel J, Audo R, Hahne M, Combe B,. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt. J Biol Chem 2005; 280: 15709-18.
17. Audo R, Combe B, Coulet B, Morel J, Hahne M,. The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases. Cell Death Differ 2009; 16: 1227-37.
18. Pundt N, Peters MA, Wunrau C, Strietholt S, Fehrmann C, Neugebauer K, et al. Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent. Arthritis Res Ther 2009; 11: R16.
19. Shi J, Zheng D, Liu Y, Sham MH, Tam P, Farzaneh F, et al. Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. Cancer Res 2005; 65: 1687-92.
20. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
21. Alvaro-Gracia JM, Zvaifler NJ, Firestein GS,. Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-γ and tumor necrosis factor-α on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. J Clin Invest 1990; 86: 1790-8.
22. Kakimoto K, Katsuki M, Hirofuji T, Iwata H, Koga T,. Isolation of T cell line capable of protecting mice against collagen-induced arthritis. J Immunol 1988; 140: 78-83.
23. Russell DW, Alexander IE, Miller AD,. DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc Natl Acad Sci U S A 1995; 92: 5719-23.
24. Zhang T, Hu J, Ding W, Wang X,. Doxorubicin augments rAAV-2 transduction in rat neuronal cells. Neurochem Int 2009; 55: 521-8.
25. Inagaki K, Ma C, Storm TA, Kay MA, Nakai H,. The role of DNA-PKcs and Artemis in opening viral DNA hairpin termini in various tissues in mice. J Virol 2007; 81: 11304-21.
26. Perlman H, Nguyen N, Liu H, Eslick J, Esser S, Walsh K, et al. Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis factor-related apoptosis-inducing ligand R2 and increased decoy receptor tumor necrosis factor-related apoptosis-inducing ligand R3. Arthritis Rheum 2003; 48: 3096-101.
27. Park YW, Ji JD, Lee JS, Ryang DW, Yoo DH,. Actinomycin D renders cultured synovial fibroblasts susceptible to tumour necrosis factor related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Scand J Rheumatol 2003; 32: 356-63.
28. Wang Z, Zhu T, Qiao C, Zhou L, Wang B, Zhang J, et al. Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat Biotechnol 2005; 23: 321-8.
29. Zincarelli C, Soltys S, Rengo G, Rabinowitz JE,. Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection. Mol Ther 2008; 16: 1073-80.
30. Adriaansen J, Khoury M, de Cortie CJ, Fallaux FJ, Bigey P, Scherman D, et al. Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF-blocking agent. Ann Rheum Dis 2007; 66: 1143-50.