Nucleus accumbens core and pathogenesis of compulsive checking

Behavioural Pharmacology

Volumn 26, Issue , 2015, Pages 200-216

  Ballester González, Javier ^a   Dvorkin Gheva, Anna ^b   Silva, Charmaine ^b   Foster, Jane A ^b   Szechtman, Henry ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

animal model; compulsive checking behavior; hyperactivity; nucleus accumbens core; obsessive compulsive disorder; quinpirole; rat; security motivation system

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 3 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; QUINPIROLE; SODIUM CHLORIDE; DOPAMINE 2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; COMPULSION; CONTROLLED STUDY; EXCITOTOXICITY; HYPERACTIVITY; LOCOMOTION; LONG TERM POTENTIATION; MALE; NEUROBIOLOGY; NONHUMAN; NUCLEUS ACCUMBENS CORE; OBSESSIVE COMPULSIVE DISORDER; PATHOGENESIS; RAT; SENSITIZATION; SHAM PROCEDURE; TASK PERFORMANCE; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; HYPERKINESIA; LONG EVANS RAT; METABOLISM; NUCLEUS ACCUMBENS; PATHOPHYSIOLOGY;

ANIMALS; COMPULSIVE BEHAVIOR; DISEASE MODELS, ANIMAL; HYPERKINESIS; MALE; NUCLEUS ACCUMBENS; QUINPIROLE; RATS; RATS, LONG-EVANS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3;

EID: 84922106051     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0000000000000112     Document Type: Article

References (140)

1. Adler CM, McDonough-Ryan P, Sax KW, Holland SK, Arndt S, Strakowski SM (2000). fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder. J Psychiatr Res 34 (4-5): 317-324.
2. Albelda N, Joel D (2012a). Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates. Neurosci Biobehav Rev 36:47-63.
3. Albelda N, Joel D (2012b). Current animal models of obsessive compulsive disorder: an update. Neuroscience 211:83-106.
4. Anderson D, Ahmed A (2003). Treatment of patients with intractable obsessivecompulsive disorder with anterior capsular stimulation. Case report. J Neurosurg 98:1104-1108.
5. Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, et al. (2012). Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosc 32:9023-9034.
6. Aouizerate B, Cuny E, Martin-Guehl C, Guehl D, Amieva H, Benazzouz A, et al. (2004a). Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression. Case report. J Neurosurg 101:682-686.
7. Aouizerate B, Guehl D, Cuny E, Rougier A, Bioulac B, Tignol J, et al. (2004b). Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Prog Neurobiol 72:195-221.
8. Baer L, Rauch SL, Ballantine HT, Martuza R, Cosgrove R, Cassem E, et al. (1995). Cingulotomy for intractable obsessive-compulsive disorder-prospective long-term follow-up of 18 patients. Arch Gen Psychiatry 52:384-392.
9. Baxter LR Jr (1992). Neuroimaging studies of obsessive compulsive disorder. Psychiatr Clin North Am 15:871-884.
10. Baxter LR Jr, Schwartz JM, Bergman KS, Szuba MP, Guze BH, Mazziotta JC, et al. (1992). Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry 49: 681-689.
11. Ben Pazi A, Szechtman H, Eilam D (2001). The morphogenesis of motor rituals in rats treated chronically with the dopamine agonist quinpirole. Behav Neurosci 115:1301-1317.
12. Benkelfat C, Nordahl TE, Semple WE, King AC, Murphy DL, Cohen RM (1990). Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Patients treated with clomipramine. Arch Gen Psychiatry 47:840-848.
13. Blanchard DC, Blanchard RJ (1988). Ethoexperimental approaches to the biology of emotion. Annu Rev Psychol 39:43-68.
14. Boulougouris V, Castane A, Robbins TW (2009a). Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior. Psychopharmacology (Berl) 202:611-620.
15. Boulougouris V, Chamberlain SR, Robbins TW (2009b). Cross-species models of OCD spectrum disorders. Psychiatry Res 170:15-21.
16. Bourne SK, Eckhardt CA, Sheth SA, Eskandar EN (2012). Mechanisms of deep brain stimulation for obsessive compulsive disorder: effects upon cells and circuits. Front Integr Neurosci 6:29.
17. Brittain J-S, Sharott A, Brown P (2014). The highs and lows of beta activity in cortico-basal ganglia loops. Eur J Neurosci 39:1951-1959.
18. Bromberg-Martin ES, Matsumoto M, Hikosaka O (2010). Dopamine in motivational control: rewarding, aversive, and alerting. Neuron 68:815-834.
19. Cardinal RN, Pennicott DR, Lakmali C, Sugathapala CL, Robbins TW, Everitt BJ (2001). Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 292:2499-2501.
20. Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006). Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry 163:1282-1284.
21. Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW, et al. (2007). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. Am J Psychiatry 164:335-338.
22. Chiocca EA, Martuza RL (1990). Neurosurgical therapy of obsessive-compulsive disorder. In: Jenike MA, Baer L, Minichiello WE, editors. Obsessive-compulsive disorders: theory and management. Vol 2: Chicago: Year Book Medical Publishers Inc.. pp. 283-294.
23. Cools AR (1980). Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: facilitation of processes involved in selecting the best strategy in a stressful situation. Behav Brain Res 1:361-378.
24. Cools R, Nakamura K, Daw ND (2011). Serotonin and dopamine: unifying affective, activational, and decision functions. Neuropsychopharmacology 36:98-113.
25. Curio E (1993). Proximate and developmental aspects of antipredator behavior. Adv Study Behav 22:135-238.
26. Da Cunha C, Gomez AA, Blaha CD (2012). The role of the basal ganglia in motivated behavior. Rev Neurosci 23 (5-6):747-767.
27. De Koning PP, Figee M, van den Munckhof P, Schuurman PR, Denys D (2011). Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets. Curr Psychiatry Rep 13:274-282.
28. Denys D, Mantione M, Figee M, van den Munckhof P, Koerselman F, Westenberg H, et al. (2010a). Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 67:1061-1068.
29. Denys D, Mantione M, Figee M, van den Munckhof P, Koerselman F, Westenberg H, et al. (2010b). Deep brain stimulation of the nucleus cccumbens for treatment-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 67:1061-1068.
30. Djodari-Irani A, Klein J, Banzhaf J, Joel D, Heinz A, Harnack D, et al. (2011). Activity modulation of the globus pallidus and the nucleus entopeduncularis affects compulsive checking in rats. Behav Brain Res 219:149-158.
31. Dougherty DD, Baer L, Cosgrove GR, Cassem EH, Price BH, Nierenberg AA, et al. (2002). Prospective long-term follow-up of 44 patients who received cingulotomy for treatment-refractory obsessive-compulsive disorder. Am J Psychiatry 159:269-275.
32. Drai D, Golani I (2001). SEE: a tool for the visualization and analysis of rodent exploratory behavior. Neurosci Biobehav Rev 25:409-426.
33. Drai D, Benjamini Y, Golani I (2000). Statistical discrimination of natural modes of motion in rat exploratory behavior. J Neurosci Methods 96:119-131.
34. Dvorkin A, Culver KE, Szechtman H (2006a). Differential effects of clorgyline on sensitization to quinpirole in rats tested in small and large environments. Psychopharmacology (Berl) 186:534-543.
35. Dvorkin A, Perreault ML, Szechtman H (2006b). Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder. Behav Brain Res 169:303-311.
36. Dvorkin A, Silva C, McMurran T, Bisnaire L, Foster J, Szechtman H (2010). Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex. Eur J Neurosci 32:1552-1563.
37. Eagle DM, Noschang C, d'Angelo LS, Noble CA, Day JO, Dongelmans ML, et al. (2014). The dopamine D2/D3 receptor agonist quinpirole increases checkinglike behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD. Behav Brain Res 264:207-229.
38. Eilam D, Golani I (1989). Home base behavior of rats (Rattus norvegicus) exploring a novel environment. Behav Brain Res 34:199-211.
39. Eilam D, Szechtman H (2005). Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: an ethologlocal approach to the form of compulsive rituals. CNS Spectr 10:191-202.
40. Eilam D, Golani I, Szechtman H (1989). D2-agonist quinpirole induces perseveration of routes and hyperactivity but no perseveration of movements. Brain Res 490:255-267.
41. Feenstra MG, Botterblom MH (1996). Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty. Brain Res 742 (1-2):17-24.
42. Feenstra MG, Botterblom MH, van Uum JF (1995). Novelty-induced increase in dopamine release in the rat prefrontal cortex in vivo: inhibition by diazepam. Neurosci Lett 189:81-84.
43. Figee M, Vink M, de Geus F, Vulink N, Veltman DJ, Westenberg H, et al. (2011). Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol Psychiatry 69:867-874.
44. Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, et al. (2013). Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat Neurosci 16:386-387.
45. Floresco SB (2013). Prefrontal dopamine and behavioral flexibility: shifting from an 'inverted-U' towards a family of functions. Front Neurosci 7:62.
46. Fontaine D, Mattei V, Borg M, von Langsdorff D, Magnie MN, Chanalet S, et al. (2004). Effect of subthalamic nucleus stimulation on obsessive-compulsive disorder in a patient with Parkinson disease. Case report. J Neurosurg 100:1084-1086.
47. Friedlander L, Desrocher M (2006). Neuroimaging studies of obsessive-compulsive disorder in adults and children. Clin Psychol Rev 26:32-49.
48. Golani I (2012). The developmental dynamics of behavioral growth processes in rodent egocentric and allocentric space. Behav Brain Res 231:309-316.
49. Golani I, Benjamini Y, Eilam D (1993). Stopping behavior: constraints on exploration in rats (Rattus norvegicus). Behav Brain Res 53 (1-2):21-33.
50. Graybiel AM, Rauch SL (2000). Toward a neurobiology of obsessive-compulsive disorder. Neuron 28:343-347.
51. Greenberg BD, Rauch SL, Haber SN (2010). Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD. Neuropsychopharmacology 35:317-336.
52. Gu BM, Park JY, Kang DH, Lee SJ, Yoo SY, Jo HJ, et al. (2008). Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder. Brain 131 (Pt 1):155-164.
53. Gurevich EV, Joyce JN (1999). Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons. Neuropsychopharmacology 20:60-80.
54. Hamani C, Temel Y (2012). Deep brain stimulation for psychiatric disease: contributions and validity of animal models. Sci Transl Med 4:142rv148.
55. Hatalova H, Radostova D, Pistikova A, Vales K, Stuchlik A (2014). Spatial reversal learning in chronically sensitized rats and in undrugged sensitized rats with dopamine d2-like receptor agonist quinpirole. Front Behav Neurosci 8:122.
56. Haynes WIA, Mallet L (2010). High-frequency stimulation of deep brain structures in obsessive-compulsive disorder: the search for a valid circuit. Eur J Neurosci 32:1118-1127.
57. Hen I, Sakov A, Kafkafi N, Golani I, Benjamini Y (2004). The dynamics of spatial behavior: how can robust smoothing techniques help? J Neurosci Methods 133 (1-2):161-172.
58. Hinds AL, Woody EZ, Van Ameringen M, Schmidt LA, Szechtman H (2012). When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting. PLoS One 7:e30586.
59. Hoffman KL (2011). Animal models of obsessive compulsive disorder: recent findings and future directions. Expert Opin Drug Discov 6:725-737.
60. Hoffman KL, Morales RIR (2009). Toward an understanding of the neurobiology of 'just right' perceptions: nest building in the female rabbit as a possible model for compulsive behavior and the perception of task completion. Behav Brain Res 204:182-191.
61. Hoffman KL, Rueda Morales RI (2012). D1 and D2 dopamine receptor antagonists decrease behavioral bout duration, without altering the bout's repeated behavioral components, in a naturalistic model of repetitive and compulsive behavior. Behav Brain Res 230:1-10.
62. Huey ED, Zahn R, Krueger F, Moll J, Kapogiannis D, Wassermann EM, et al. (2008). A psychological and neuroanatomical model of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 20:390-408.
63. Huff W, Lenartz D, Schormann M, Lee SH, Kuhn J, Koulousakis A, et al. (2010). Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: outcomes after one year. Clin Neurol Neurosurg 112:137-143.
64. Imperato A, Tanda G, Frau R, Di Chiara G (1988). Pharmacological profile of dopamine receptor agonists as studied by brain dialysis in behaving rats. J Pharmacol Exp Ther 245:257-264.
65. Jenike MA, Baer L, Ballantine T, Martuza RL, Tynes S, Giriunas I, et al. (1991). Cingulotomy for refractory obsessive-compulsive disorder. A long-term follow-up of 33 patients. Arch Gen Psychiatry 48:548-555.
66. Joel D (2006a). Current animal models of obsessive compulsive disorder: a critical review. Prog Neuropsychopharmacol Biol Psychiatry 30:374-388.
67. Joel D (2006b). The signal attenuation rat model of obsessive-compulsive disorder: a review. Psychopharmacology (Berl) 186:487-503.
68. Jongen-Relo AL, Feldon J (2002). Specific neuronal protein: a new tool for histological evaluation of excitotoxic lesions. Physiol Behav 76 (4-5):449-456.
69. Kettl PA, Marks IM (1986). Neurological factors in obsessive compulsive disorder. Two case reports and a review of the literature. Br J Psychiatry 149:315-319.
70. Kim JJ, Lee MC, Kim J, Kim IY, Kim SI, Hee HM, et al. (2001). Grey matter abnormalities in obsessive-compulsive disorder: statistical parametric mapping of segmented magnetic resonance images. Br J Psychiatry 179:330-334.
71. Klanker M, Feenstra M, Denys D (2013). Dopaminergic control of cognitive flexibility in humans and animals. Front Neurosci 7:201.
72. Koeltzow TE, Austin JD, Vezina P (2003). Behavioral sensitization to quinpirole is not associated with increased nucleus accumbens dopamine overflow. Neuropharmacology 44:102-110.
73. Kohl S, Schonherr DM, Luigjes J, Denys D, Mueller UJ, Lenartz D, et al. (2014). Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review. BMC Psychiatry 14:214.
74. Korff S, Harvey BH (2006). Animal models of obsessive-compulsive disorder: rationale to understanding psychobiology and pharmacology. Psychiatr Clin North Am 29:371-390.
75. Kurylo DD (2004). Effects of quinpirole on operant conditioning: perseveration of behavioral components. Behav Brain Res 155:117-124.
76. Leckman JF, Grice DE, Barr LC, de Vries AL, Martin C, Cohen DJ, et al. (1994). Tic-related vs. non-tic-related obsessive compulsive disorder. Anxiety 1:208-215.
77. Legault M, Wise RA (2001). Novelty-evoked elevations of nucleus accumbens dopamine: dependence on impulse flow from the ventral subiculum and glutamatergic neurotransmission in the ventral tegmental area. Eur J Neurosci 13:819-828.
78. Lima SL, Bednekoff PA (1999). Back to the basics of antipredatory vigilance: can nonvigilant animals detect attack? Anim Behav 58:537-543.
79. Mallet L, Mesnage V, Houeto JL, Pelissolo A, Yelnik J, Behar C, et al. (2002). Compulsions, Parkinson's disease, and stimulation. Lancet 360:1302-1304.
80. Man J, Hudson AL, Ashton D, Nutt DJ (2004). Animal models for obsessivecompulsive disorder. Curr Neuropharmacol 2:169-181.
81. Mataix-Cols D, Wooderson S, Lawrence N, Brammer MJ, Speckens A, Phillips ML (2004). Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 61:564-576.
82. McCracken CB, Grace AA (2007). High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo. J Neurosci 27:12601-12610.
83. McGuire PK, Bench CJ, Frith CD, Marks IM, Frackowiak RS, Dolan RJ (1994). Functional anatomy of obsessive-compulsive phenomena. Br J Psychiatry 164:459-468.
84. McIntyre CC, Hahn PJ (2010). Network perspectives on the mechanisms of deep brain stimulation. Neurobiol Dis 38:329-337.
85. Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 32:525-549.
86. Modell JG, Mountz JM, Curtis GC, Greden JF (1989). Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 1:27-36.
87. Mogenson GJ, Jones DL, Yim CY (1980). From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14 (2-3):69-97.
88. Mundt A, Klein J, Joel D, Heinz A, Djodari-Irani A, Harnack D, et al. (2009). Highfrequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats. Eur J Neurosci 29:2401-2412.
89. Noldus LP, Spink AJ, Tegelenbosch RA (2001). EthoVision: a versatile video tracking system for automation of behavioral experiments. Behav Res Methods Instrum Comput 33:398-414.
90. Nuttin BJ, Gabriels LA, Cosyns PR, Meyerson BA, Andreewitch S, Sunaert SG, et al. (2003). Long-term electrical capsular stimulation in patients with obsessive-compulsive disorder. Neurosurgery 52:1263-1272.
91. Oades RD (1985). The role of noradrenaline in tuning and dopamine in switching between signals in the CNS. Neurosci Biobehav Rev 9:261-282.
92. Paxinos G,Watson C (1998). The rat brain in stereotaxic coordinates. 4th ed San Diego: Academic Press.
93. Phillips ML, Mataix-Cols D (2004). Patterns of neural response to emotive stimuli distinguish the different symptom dimensions of obsessive-compulsive disorder. CNS Spectr 9:275-283.
94. Pitman RK (1989). Animal models of compulsive behavior. Biol Psychiatry 26:189-198.
95. Rasmussen SA, Eisen JL (1992). The epidemiology and differential-diagnosis of obsessive-compulsive disorder. J Clin Psychiatry 53:4-10.
96. Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, et al. (1994). Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 51:62-70.
97. Rauch SL, Dougherty DD, Malone D, Rezai A, Friehs G, Fischman AJ, et al. (2006). A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder. J Neurosurg 104:558-565.
98. Reed GF (1985). Obsessional experience and compulsive behaviour: a cognitive-structural approach. Orlando, FL: Academic Press Inc.; p. 246.
99. Rodriguez-Romaguera J, Do Monte FHM, Quirk GJ (2012). Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear. Proc Natl Acad Sci 109:8764-8769.
100. Rotge JY, Guehl D, Dilharreguy B, Cuny E, Tignol J, Bioulac B, et al. (2008). Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiatry Neurosci 33:405-412.
101. Rotge J-Y, Langbour N, Jaafari N, Guehl D, Bioulac B, Aouizerate B, et al. (2010). Anatomical alterations and symptom-related functional activity in obsessive-compulsive disorder are correlated in the lateral orbitofrontal cortex. Biol Psychiatry 67:e37-e38.
102. Salamone JD, Correa M, Farrar AM, Nunes EJ, Pardo M (2009). Dopamine, behavioral economics, and effort. Front Behav Neurosci 3:13.
103. Saxena S, Brody AL, Schwartz JM, Baxter LR (1998). Neuroimaging and frontalsubcortical circuitry in obsessive-compulsive disorder. Br J Psychiatr Suppl 35:26-37.
104. Shah RS, Chang SY, Min HK, Cho ZH, Blaha CD, Lee KH (2010). Deep brain stimulation: technology at the cutting edge. J Clin Neurol 6:167-182.
105. Spink AJ, Tegelenbosch RA, Buma MO, Noldus LP (2001). The EthoVision video tracking system - a tool for behavioral phenotyping of transgenic mice. Physiol Behav 73:731-744.
106. Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz K, Klein JC, et al. (2003). The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive-and anxiety-disorders. J Chem Neuroanat 26:293-299.
107. Summerfeldt LJ (2004). Understanding and treating incompleteness in obsessive-compulsive disorder. J Clin Psychol 60:1155-1168.
108. Swedo SE, Pietrini P, Leonard HL, Schapiro MB, Rettew DC, Goldberger EL, et al. (1992). Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Revisualization during pharmacotherapy. Arch Gen Psychiatry 49:690-694.
109. Szechtman H,Woody E (2004). Obsessive-compulsive disorder as a disturbance of security motivation. Psychol Rev 111:111-127.
110. Szechtman H, Eilam D (2005). Psychiatric models. In: Whishaw IQ, Kolb B, editors. The behavior of the laboratory rat: a handbook with tests. New York: Oxford University Press. pp. 462-474.
111. Szechtman H, Woody EZ (2006). Obsessive-compulsive disorder as a disturbance of security motivation: constraints on comorbidity. Neurotox Res 10:103-112.
112. Szechtman H, Talangbayan H, Canaran G, Dai H, Eilam D (1994). Dynamics of behavioral sensitization induced by the dopamine agonist quinpirole and a proposed central energy control mechanism [published erratum appears in Psychopharmacology (Berl) 1994 Sep;116(1):124]. Psychopharmacology (Berl) 115:95-104.
113. Szechtman H, Sulis W, Eilam D (1998). Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav Neurosci 112:1475-1485.
114. Szechtman H, Culver K, Eilam D (1999). Role of dopamine systems in obsessive-compulsive disorder (OCD): implications from a novel psychostimulant-induced animal model. Pol J Pharmacol 51:55-61.
115. Szechtman H, Shivji S, Woody E (2014). Pathophysiology of obsessive-compulsive disorder: insights from normal function and neurotoxic effects of drugs, infection, and brain injury. In: Kostrzewa RM, editor. Handbook of neurotoxicity. New York: Springer. pp. 2231-2253.
116. Tass PA, Klosterkotter J, Schneider F, Lenartz D, Koulousakis A, Sturm V (2003). Obsessive-compulsive disorder: development of demand-controlled deep brain stimulation with methods from stochastic phase resetting. Neuropsychopharmacology 28 (S1):S27-S34.
117. Teitelbaum P (2012). Some useful insights for graduate students beginning their research in physiological psychology: anecdotes and attitudes. Behav Brain Res 231:234-249.
118. Teitelbaum P, Pellis SM (1992). Toward a synthetic physiological psychology. Psychol Sci 3:4-20.
119. Tolkamp BJ, Kyriazakis I (1999). To split behaviour into bouts, log-transform the intervals. Anim Behav 57:807-817.
120. Tolkamp BJ, Allcroft DJ, Austin EJ, Nielsen BL, Kyriazakis I (1998). Satiety splits feeding behaviour into bouts. J Theor Biol 194:235-250.
121. Tucci MC, Dvorkin-Gheva A, Graham D, Amodeo S, Cheon P, Kirk A, et al. (2013). Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD). Psychopharmacology (Berl) 227:277-285.
122. Tucci MC, Dvorkin-Gheva A, Johnson E, Cheon P, Taji L, Agarwal A, et al. (2014a). Performance of compulsive behavior in rats is not a unitary phenomenon-validation of separate functional components in compulsive checking behavior. Eur J Neurosci 40:2971-2979.
123. Tucci MC, Dvorkin-Gheva A, Sharma R, Taji L, Cheon P, Peel J, et al. (2014b). Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD). Psychopharmacology (Berl) 231:3707-3718.
124. Van den Bos R, Cools AR (1989). The involvement of the nucleus accumbens in the ability of rats to switch to cue-directed behaviours. Life Sci 44:1697-1704.
125. Van den Heuvel OA, Veltman DJ, Groenewegen HJ, Dolan RJ, Cath DC, Boellaard R, et al. (2004). Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography. Psychiatry Res 132:225-237.
126. Wahl K, Salkovskis PM, Cotter I (2008). 'I wash until it feels right' - the phenomenology of stopping criteria in obsessive-compulsive washing. J Anxiety Disord 22:143-161.
127. Weiss O, Segev E, Eilam D (2014). 'Shall two walk together except they be agreed?' Spatial behavior in rat dyads. Anim Cogn [Epub ahead of print].
128. Westenberg HG, Fineberg NA, Denys D (2007). Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS Spectr 12 (Suppl 3):14-27.
129. Whitaker NG, Lindstrom TD (1987). Disposition and biotransformation of quinpirole, a new D-2 dopamine agonist antihypertensive agent, in mice, rats, dogs, and monkeys. Drug Metab Dispos 15:107-113.
130. Wingfield JC, Maney DL, Breuner CW, Jacobs JD, Lynn S, Ramenofsky M, et al. (1998). Ecological bases of hormone-behavior interactions: The 'Emergency Life History Stage'. Am Zool 38:191-206.
131. Winter C (2012). Obsessive-compulsive disorders in animals. In: Denys D, Feenstra M, Schuurman R, editors. Deep brain stimulation. Berlin, Heidelberg: Springer. pp. 61-70.
132. Winter C, Mundt A, Jalali R, Joel D, Harnack D, Morgenstern R, et al. (2008). High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats. Exp Neurol 210:217-228.
133. Wise RA (2005). Forebrain substrates of reward and motivation. J Comp Neurol 493:115-121.
134. Wise RA (2013). Dual roles of dopamine in food and drug seeking: the drivereward paradox. Biol Psychiatry 73:819-826.
135. Wise S, Rapoport JL (1989). Obsessive compulsive disorder-is it a basal ganglia dysfunction? In: Rapoport J, editor. Obsessive compulsive disorder in children and adolescence. Washington, DC: American Psychiatric Press. pp. 327-344.
136. Woody EZ, Szechtman H (2005). Motivation, time course, and heterogeneity in obsessive-compulsive disorder: response to Taylor, McKay, and Abramowitz (2005). Psychol Rev 112:658-661.
137. Woody EZ, Szechtman H (2011). Adaptation to potential threat: the evolution, neurobiology, and psychopathology of the security motivation system. Neurosci Biobehav Rev 35:1019-1033.
138. Woody EZ, Szechtman H (2013). A biological security motivation system for potential threats: are there implications for policy-making? Front Hum Neurosci 7:556.
139. Zahm DS (2000). An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci Biobehav Rev 24:85-105.
140. Zor R, Szechtman H, Hermesh H, Fineberg NA, Eilam D (2011). Manifestation of incompleteness in obsessive-compulsive disorder (OCD) as reduced functionality and extended activity beyond task completion. PLoS ONE 6:e25217.