Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: Investigation of D3 receptor involvement in persistent behavior

Psychopharmacology

Volumn 202, Issue 4, 2009, Pages 611-620

  Boulougouris, Vasileios ^a   Castañé, Anna ^a,b   Robbins, Trevor W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Animal model; Discrimination; Dopamine; Learning; Nafadotride; Obsessive compulsive disorder; Perseveration; Quinpirole; Raclopride; Reversal learning

Indexed keywords

DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE 3 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR STIMULATING AGENT; NAFADOTRIDE; QUINPIROLE; RACLOPRIDE;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; LEARNING; NONHUMAN; PERSEVERATION; PRIORITY JOURNAL; RAT; REINFORCEMENT; SPATIAL DISCRIMINATION; STIMULUS RESPONSE; TASK PERFORMANCE;

ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; MALE; NAPHTHALENES; PSYCHOMOTOR PERFORMANCE; PYRROLIDINES; QUINPIROLE; RACLOPRIDE; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; REVERSAL LEARNING; SERIAL LEARNING; SPACE PERCEPTION;

EID: 59849129566     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1341-2     Document Type: Article

References (50)

1. EA Billett MA Richter F Sam RP Swinson XY Dai N King F Badri T Sasaki JA Buchanan JL Kennedy 1998 Investigation of dopamine system genes in obsessive-compulsive disorder Psychiatr Genet 8 163 169
2. JM Birrell VJ Brown 2000 Medial frontal cortex mediates perceptual attentional set shifting in the rat J Neurosci 20 4320 4324
3. V Boulougouris JW Dalley TW Robbins 2007 Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat Behav Brain Res 179 219 228
4. V Boulougouris JC Glennon TW Robbins 2008 Dissociable effects of selective 5-HT(2A) and 5-HT(2C) receptor antagonists on serial spatial reversal learning in rats Neuropsychopharmacology 33 2007 2019
5. TJ Bussey JL Muir BJ Everitt TW Robbins 1997 Triple dissociation of anterior cingulate, posterior cingulate, and medial frontal cortices on visual discrimination tasks using a touchscreen testing procedure for the rat Behav Neurosci 111 920 936
6. CM Butter 1969 Impairments in selective attention to visual stimuli in monkeys with inferotemporal and lateral striate lesions Brain Res 12 374 383
7. M Catalano G Sciuto D Di Bella E Novelli M Nobile L Bellodi 1994 Lack of association between obsessive-compulsive disorder and the dopamine D3 receptor gene: some preliminary considerations Am J Med Genet 54 253 255
8. YH Chang RM Liao 2003 Differential effects of dopamine D1 and D2 receptor antagonists on conditioned orienting behavior in the rat Chin J Physiol 46 159 168
9. Y Chudasama TW Robbins 2003 Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex J Neurosci 23 8771 8780
10. HF Clarke JW Dalley HS Crofts TW Robbins AC Roberts 2004 Cognitive inflexibility following prefrontal serotonin depletion Science 304 878 880
11. HF Clarke SC Walker HS Crofts JW Dalley TW Robbins AC Roberts 2005 Prefrontal serotonin depletion affects reversal learning but not attentional set shifting J Neurosci 25 532 538
12. H Clarke S Walker J Dalley T Robbins A Roberts 2007 Cognitive inflexibility after prefrontal depletion is behaviorally and neurochemically specific Cereb Cortex 17 18 27
13. D Denys N van der Wee J Janssen F De Geus HG Westenberg 2004 Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder Biol Psychiatry 55 1041 1045
14. R Dias TW Robbins AC Roberts 1996 Dissociation in prefrontal cortex of affective and attentional shifts Nature 380 69 72
15. I Divac HE Rosvold MK Szwarcbart 1967 Behavioral effects of selective ablation of the caudate nucleus J Comp Physiol Psychol 63 184 190
16. SB Dunnett SD Iversen 1980 Regulatory impairments following selective kainic acid lesions of the neostriatum Behav Brain Res 1 497 506
17. D Eilam I Golani H Szechtman 1989 D2-agonist quinpirole induces perseveration of routes and hyperactivity but no perseveration of movements Brain Res 490 255 267
18. LK Fellows MJ Farah 2003 Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm Brain 126 1830 1837
19. AT Ferry XC Lu JL Price 2002 Effects of excitotoxic lesions in the ventral striatopallidal-thalamocortical pathway on odor reversal learning: inability to extinguish an incorrect response Exp Brain Res 131 320 335
20. SB Floresco O Magyar S Ghods-Sharifi C Vexelman MT Tse 2006 Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting Neuropsychopharmacology 31 297 309
21. SC Fowler JR Liou 1998 Haloperidol, raclopride, and eticlopride induce microcatalepsy during operant performance in rats, but clozapine and SCH 23390 do not Psychopharmacology (Berl) 140 81 90
22. NF Idris P Repeto JC Neill CH Large 2005 Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat Psychopharmacology 179 336 348
23. A Izquierdo LM Wiedholz RA Millstein RJ Yang TJ Bussey LM Sakside 2006 Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for mice Behav Brain Res 171 181 188
24. D Joel A Avisar J Doljansky 2001 Enhancement of excessive lever-pressing after post-training signal attenuation in rats by repeated administration of the D1 antagonist SCH 23390 or the D2 agonist quinpirole, but not the D1 agonist SKF 38393 or the D2 antagonist haloperidol Behav Neurosci 115 1291 300
25. B Jones M Mishkin 1972 Limbic lesions and the problem of stimulus-reinforcement associations Exp Neurol 36 362 377
26. RJ Kirkby 1969 Caudate nucleus lesions impair spontaneous alternation Percept Mot Skills 29 550
27. B Kolb 1997 Studies on the caudate-putamen and the dorsomedial thalamic nucleus of the rat: Implications for mammalian frontal-lobe functions Physiol Behav 18 237 244
28. Kontis D, Boulougouris V, Papakosta VM, Kalogerakou S, Papadopoulos S, Giannou H, Poulopoulou C, Tsaltas E (2008) Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder. Psychopharmacology (Berlin). doi: 10.1007/s00213-008-1241-5
29. PJ Kruzich DK Grandy 2004 Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice BMC Neurosci 5 12
30. DD Kurylo S Tanguay 2003 Effects of quinpirole on behavioral extinction Physiol Behav 80 1 7
31. B Lee S Groman ED London JD Jentsch 2007 Dopamine D(2)/D(3) receptors play a specific role in the reversal of a learned visual discrimination in monkeys Neuropsychopharmacology 32 2125 2134
32. B Levant NR Vansell 1997 In vivo occupancy of D2 dopamine receptors by nafadotride Neuropsychopharmacology 17 67 71
33. K McAlonan VJ Brown 2003 Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat Behav Brain Res 146 97 103
34. CJ McDougle WK Goodman LH Price 1994 Dopamine antagonists in tic-related and psychotic spectrum obsessive compulsive disorder J Clin Psychiatry 55 Suppl 13 24 31
35. CJ McDougle WK Goodman JF Leckman NC Lee GR Heninger LH Price 1994 Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind placebo controlled study in patients with and without tics Arch Gen Psychiatry 51 302 308
36. JG Modell JM Mountz GC Curtis JF Greden 1989 Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder J Neuropsychiatry 1 27 36
37. FC Murphy KA Smith PJ Cowen TW Robbins BJ Sahakian 2002 The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers Psychopharmacology 163 42 53
38. DL Pauls KE Towbin JF Leckman GE Zahner DJ Cohen 1986 Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship Arch Gen Psychiatry 43 1180 1182
39. ME Ragozzino 2002 The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility Learn Mem 9 18 28
40. ME Ragozzino D Choi 2004 Dynamic changes in acetylcholine output in the medial striatum during place reversal learning Learn Mem 11 70 77
41. ME Ragozzino J Jih A Tzavos 2002 Involvement of the dorsomedial striatum in behavioral flexibility: role of muscarinic cholinergic receptors Brain Res 953 205 14
42. ME Ragozzino KE Ragozzino SJ Mizumori RP Kesner 2002 Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning Behav Neurosci 116 105 115
43. RM Ridley TA Haystead HF Baker 1981 An analysis of visual object reversal learning in the marmoset after amphetamine and haloperidol Pharmacol Biochem Behav 14 345 351
44. RD Rogers TC Andrews PM Grasby DJ Brooks TW Robbins 2000 Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans J Cogn Neurosci 12 142 162
45. ET Rolls J Hornak D Wade J McGrath 1994 Emotion related learning in patients with social and emotional changes associated with frontal lobe damage J Neurol Neurosurg Psychiatry 57 1518 1524
46. RM Sullivan H Talangbayan H Einat H Szechtman 1998 Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats Neuroscience 83 781 789
47. H Szechtman W Sulis D Eilam 1998 Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD) Behav Neurosci 112 1475 1485
48. H Szechtman MJ Eckert WS Tse JT Boersma CA Bonura JZ McClelland KE Culver D Eilam 2001 Compulsive checking behavior of quinpirole-sensitized rats as an animal model of obsessive-compulsive disorder (OCD): form and control BMC Neuroscience 2 4
49. JA van der Meulen RN Joosten JP de Bruin MG Feenstra 2006 Dopamine and noradrenaline efflux in the medial prefrontal cortex during serial reversals and extinction of instrumental goal-directed behavior Cereb Cortex 17 1444 1453
50. I Weiner J Feldon 1986 Reversal and nonreversal shifts under amphetamine Psychopharmacology 89 355 359