Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38+ Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis

Digestive Diseases and Sciences

Volumn 60, Issue 2, 2015, Pages 405-413

  Wang, Li ^a   Sun, Xiguang ^a   Qiu, Jinpeng ^a   Cai, Yanjun ^a   Ma, Liang ^a   Zhao, Pingwei ^a   Jiang, Yanfang ^a,b  

^a JILIN UNIVERSITY   (China)

^b YANGZHOU UNIVERSITY   (China)

Author keywords

Follicular helper T (Tfh) cells; ICOS; IL 21; Plasma cells; Primary biliary cirrhosis (PBC)

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CD19 ANTIGEN; CD27 ANTIGEN; CD3 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD86 ANTIGEN; FAS LIGAND; GAMMA GLUTAMYLTRANSFERASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 21; MITOCHONDRION ANTIBODY; PROGRAMMED DEATH 1 LIGAND 1; AUTOANTIBODY; BIOLOGICAL MARKER; CD38 PROTEIN, HUMAN; ICOS PROTEIN, HUMAN; IMMUNOGLOBULIN; INTERLEUKIN DERIVATIVE; MEMBRANE PROTEIN;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; FOLLICULAR HELPER T CELL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PLASMA CELL; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; AUTOIMMUNITY; BLOOD; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; CELL CULTURE; IMMUNOLOGY; LIVER CIRRHOSIS, BILIARY; METABOLISM; MIDDLE AGED; UPREGULATION;

ADULT; AGED; ANTIGENS, CD38; AUTOANTIBODIES; AUTOIMMUNITY; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CELLS, CULTURED; FEMALE; HUMANS; IMMUNOGLOBULINS; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; INTERLEUKINS; LIVER CIRRHOSIS, BILIARY; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PLASMA CELLS; T-LYMPHOCYTES, HELPER-INDUCER; UP-REGULATION;

EID: 84922104459     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-014-3372-3     Document Type: Article

References (34)

1. Lindor KD, Gershwin ME, Poupon R, et al. Primary biliary cirrhosis. Hepatology. 2009;50:291–308.
2. Saito H, Takahashi A, Abe K, et al. Autoantibodies by line immunoassay in patients with primary biliary cirrhosis. Fukushima J Med Sci. 2012;58:107–116.
3. Hirschfield GM, Chapman RW, Karlsen TH, Lammert F, Lazaridis KN, Mason AL. The genetics of complex cholestatic disorders. Gastroenterology. 2013;144:1357–1374.
4. McNally RJ, James PW, Ducker S, James OF. Seasonal variation in the patient diagnosis of primary biliary cirrhosis: further evidence for an environmental component to etiology. Hepatology. 2011;54:2099–2103.
5. Selmi C, Bowlus CL, Gershwin ME, Coppel RL. Primary biliary cirrhosis. Lancet. 2011;377:1600–1609.
6. Takahashi T, Miura T, Nakamura J, et al. Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis. Hepatology. 2012;55:846–855.
7. Dhirapong A, Lleo A, Yang GX, et al. B cell depletion therapy exacerbates murine primary biliary cirrhosis. Hepatology. 2011;53:527–535.
8. Zhao LD, Li Y, Smith MF Jr, et al. Expressions of BAFF/BAFF receptors and their correlation with disease activity in Chinese SLE patients. Lupus. 2010;19:1534–1549.
9. Zhong X, Tumang JR, Gao W, Bai C, Rothstein TL. PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding. Eur J Immunol. 2007;37:2405–2410.
10. Agematsu K. Memory B cells and CD27. Histol Histopathol. 2000;15:573–576.
11. Bernuzzi F, Fenoglio D, Battaglia F, et al. Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis. J Autoimmun. 2010;35:176–180.
12. Zhang W, Sharma R, Ju ST, et al. Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis. Hepatology. 2009;49:545–552.
13. Patakas A, Platt AM, Butcher JP, et al. Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease. Immunol Lett. 2011;138:38–46.
14. Zhang X, Ing S, Fraser A, et al. Follicular helper T cells: new insights into mechanisms of autoimmune diseases. Ochsner J. 2013;13:131–139.
15. Linterman MA, Liston A, Vinuesa CG. T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells. Immunol Rev. 2012;247:143–159.
16. Riella LV, Paterson AM, Sharpe AH, Chandraker A. Role of the PD-1 pathway in the immune response. Am J Transplant. 2012;12:2575–2587.
17. Chen J, Wang F, Cai Q, et al. A novel anti-human ICOSL monoclonal antibody that enhances IgG production of B cells. Monoclon Antib Immunodiagn Immunother. 2013;32:125–131.
18. Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol. 2011;29:621–663.
19. Nurieva RI, Chung Y, Martinez GJ, et al. Bcl6 mediates the development of T follicular helper cells. Science. 2009;325:1001–1005.
20. Yu D, Rao S, Tsai LM, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity. 2009;31:457–468.
21. Feng X, Wang D, Chen J, et al. Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLoS ONE. 2012;7:e51982.
22. Medicetty S, Wiktor D, Lehman N, et al. Percutaneous adventitial delivery of allogeneic bone marrow-derived stem cells via infarct-related artery improves long-term ventricular function in acute myocardial infarction. Cell Transplant. 2012;21:1109–1120.
23. Zotos D, Coquet JM, Zhang Y, et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med. 2010;207:365–378.
24. Baldursdottir TR, Bergmann OM, Jonasson JG, Ludviksson BR, Axelsson TA, Bjornsson ES. The epidemiology and natural history of primary biliary cirrhosis: a nationwide population-based study. Eur J Gastroenterol Hepatol. 2012;24:824–830.
25. Aoki N, Kido M, Iwamoto S, et al. Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice. Gastroenterology. 2011;140:1322–1333.
26. Feng X, Wang D, Chen J, et al. Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLoS ONE. 2012;7:e51982.
27. Odendahl M, Jacobi A, Hansen A, et al. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol. 2000;165:5970–5979.
28. Reinehr R, Gorg B, Hongen A, Haussinger D. CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes. J Biol Chem. 2004;279:10364–10373.
29. Horst A, Hunzelmann N, Arce S, et al. Detection and characterization of plasma cells in peripheral blood: correlation of IgE+ plasma cell frequency with IgE serum titre. Clin Exp Immunol. 2002;130:370–378.
30. Linterman MA, Vinuesa CG. T follicular helper cells during immunity and tolerance. Prog Mol Biol Transl Sci. 2010;92:207–248.
31. Eto D, Lao C, DiToro D, et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS ONE. 2011;6:e17739.
32. Pene J, Gauchat JF, Lecart S, et al. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol. 2004;172:5154–5157.
33. Morita R, Schmitt N, Bentebibel SE, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011;34:108–121.
34. Ding Y, Li J, Yang P, et al. IL-21 promotes germinal center reaction by skewing the Tfr/Tfh balance in autoimmune BXD2 mice. Arthritis Rheumatol. 06/06/2014 (Epub ahead of print). doi:10.1002/art.38735.