Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice

Gastroenterology

Volumn 140, Issue 4, 2011, Pages 1322-1333.e5

  Aoki, Nobuhiro ^a   Kido, Masahiro ^a   Iwamoto, Satoru ^a   Nishiura, Hisayo ^a   Maruoka, Ryutaro ^a   Tanaka, Junya ^a   Watanabe, Takeshi ^a   Tanaka, Yoshimasa ^a   Okazaki, Taku ^b   Chiba, Tsutomu ^a   Watanabe, Norihiko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Autoimmune Liver Disease; Follicular Helper T Cells; Pathogenesis

Indexed keywords

ANTINUCLEAR ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR6; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE HEPATITIS; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FATALITY; GENE EXPRESSION; GERMINAL CENTER; HELPER CELL; IMMUNOREGULATION; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN; SPLENECTOMY; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 79953203547     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.01.002     Document Type: Article

References (31)

1. E.L. Krawitt Autoimmune hepatitis N Engl J Med 354 2006 54 66 (Pubitemid 43048951)
2. M.P. Manns, and A. Vogel Autoimmune hepatitis, from mechanisms to therapy Hepatology 43 2006 S132 S144
3. M. Kido, N. Watanabe, and T. Okazaki Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling Gastroenterology 135 2008 1333 1343
4. I. Diamantis, and D.T. Boumpas Autoimmune hepatitis: evolving concepts Autoimmun Rev 3 2004 207 214 (Pubitemid 38521096)
5. Y. Ichiki, C.A. Aoki, and C.L. Bowlus T cell immunity in autoimmune hepatitis Autoimmun Rev 4 2005 315 321 (Pubitemid 40884551)
6. Y. Suzuki, M. Kobayashi, and T. Hosaka Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis J Gastroenterol 39 2004 649 653 (Pubitemid 39149352)
7. L.J. McHeyzer-Williams, N. Pelletier, and L. Mark Follicular helper T cells as cognate regulators of B cell immunity Curr Opin Immunol 21 2009 266 273
8. C. King New insights into the differentiation and function of T follicular helper cells Nat Rev Immunol 9 2009 757 766
9. D. Yu, M. Batten, and C.R. Mackay Lineage specification and heterogeneity of T follicular helper cells Curr Opin Immunol 21 2009 619 625
10. N. Simpson, P.A. Gatenby, and A. Wilson Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systematic lupus erythematosus Arthritis Rheum 62 2010 234 244
11. G. Monteleone, F. Pallone, and T.T. Macdonald Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease Cytokine Growth Factor Rev 20 2009 185 191
12. T. Korn, E. Bettelli, and M. Oukka IL-17 and Th17 cells Annu Rev Immunol 27 2009 485 517
13. A. Reboldi, C. Coisne, and D. Baumjohann C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE Nat Immunol 10 2009 514 523
14. K. Hirota, H. Yoshitomi, and M. Hashimoto Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model J Exp Med 204 2007 2803 2812 (Pubitemid 350179551)
15. T. Yamazaki, X.O. Yang, and Y. Chung CCR6 regulates the migration of inflammatory and regulatory T cells J Immunol 181 2008 8391 8401
16. E.V. Acosta-Rodriguez, L. Rivino, and J. Geginat Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells Nat Immunol 8 2007 639 646 (Pubitemid 46785128)
17. K.L. Good-Jacobson, C.G. Szumilas, and L. Chen PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells Nat Immunol 11 2010 535 542
18. N. Fazilleau, L.J. McHeyzer-Williams, and H. Rosen The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding Nat Immunol 10 2009 375 384
19. T. Oikawa, H. Takahashi, and T. Ishikawa Intrahepatic expression of the co-stimulatory molecules programmed death-1, and its ligands in autoimmune liver disease Pathol Int 57 2007 485 492 (Pubitemid 47030132)
20. R. Kassel, M.W. Cruise, and J.C. Iezzoni Chronically inflamed livers up-regulate expression of inhibitory B7 family members Hepatology 50 2009 1625 1637
21. A. Vogel, E. Heinrich, and M.J. Bahr Long-term outcome of liver transplantation for autoimmune hepatitis Clin Transplant 18 2004 62 69 (Pubitemid 38195546)
22. I.A. Rowe, K. Webb, and B.K. Gunson The impact of disease recurrence on graft survival following liver transplantation: a single centre experience Transpl Int 21 2008 459 465 (Pubitemid 351490169)
23. M.A. Linterman, R.J. Rigby, and R.K. Wong Follicular helper T cells are required for systemic autoimmunity J Exp Med 206 2009 561 576
24. H. Nishimura, T. Okazaki, and Y. Tanaka Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice Science 291 2001 319 322 (Pubitemid 32096320)
25. Y. Shinkai, G. Rathbun, and K.P. Lam RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement Cell 68 1992 855 867
26. M. Kido, N. Watanabe, and T. Okazaki Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling Gastroenterology 135 2008 1333 1343
27. K.D. Klonowski, A.L. Marzo, and K.J. Williams CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen J Immunol 177 2006 6738 6746 (Pubitemid 44715038)
28. M. Muramatsu, K. Kinoshita, and S. Fagarasan Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Cell 102 2000 553 563
29. G. Blobel, and V.R. Potter Nuclei from rat liver: isolation method that combines purity with high yield Science 154 1966 1662 1665
30. M. Ishida, Y. Iwai, and Y. Tanaka Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues Immunol Lett 84 2002 57 62 (Pubitemid 34879920)
31. M. Kido, J. Tanaka, and N. Aoki Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses Infect Immun 78 2010 108 114