Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide

Angewandte Chemie - International Edition

Volumn 54, Issue 6, 2015, Pages 1859-1863

  He, Qing Li ^a   Titov, Denis V ^a,d   Li, Jing ^c   Tan, Minjia ^c   Ye, Zhaohui ^a   Zhao, Yingming ^c   Romo, Daniel ^b   Liu, Jun O ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

,target validation; Inhibitors; Medicinal chemistry; Natural products; Transcription factors

Indexed keywords

AMINO ACIDS; CELL CULTURE; CORROSION INHIBITORS; TRANSCRIPTION FACTORS;

CHINESE MEDICINAL PLANTS; COVALENT MODIFICATIONS; CYSTEINE RESIDUES; IMMUNOSUPPRESSIVE DRUGS; MEDICINAL CHEMISTRY; MUTANT PROTEINS; NATURAL PRODUCTS; TARGET VALIDATIONS;

TRANSCRIPTION;

CYSTEINE; EPOXIDE; TRANSCRIPTION FACTOR IIH;

CYSTEINE; EPOXY COMPOUNDS; TRANSCRIPTION FACTOR TFIIH;

EID: 84922031744     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201408817     Document Type: Article

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