Synthesis and biological evaluation of novel triptolide analogues for anticancer activity

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6217-6221

  Zhou, Bing ^a   Miao, Zehong ^a   Deng, Gang ^a   Ding, Jian ^a   Yang, Yaxi ^a   Feng, Huijin ^a   Li, Yuanchao ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

9,11 Olefin; A B cis ring junction; Five membered unsaturated lactam ring; Structure activity relationships; Triptolide

Indexed keywords

ANTINEOPLASTIC AGENT; LACTAM; TRIPTOLIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; MALE; OVARY CANCER; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; HUMANS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; PHENANTHRENES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIPTERYGIUM;

EID: 77957876205     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.106     Document Type: Article

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