메뉴 건너뛰기




Volumn 182, Issue 4, 2014, Pages 363-367

The Autophagic Response to Radiation: Relevance for Radiation Sensitization in Cancer Therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHLOROQUINE; HYDROXYCHLOROQUINE; RADIOSENSITIZING AGENT;

EID: 84922021353     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13774.1     Document Type: Review
Times cited : (33)

References (37)
  • 1
    • 0035863399 scopus 로고    scopus 로고
    • A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    • Paglin S, Holliter T, Delohery T, Hackett N, McMahill M, Sphicas E, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61:439-44.
    • (2001) Cancer Res , vol.61 , pp. 439-444
    • Paglin, S.1    Holliter, T.2    Delohery, T.3    Hackett, N.4    McMahill, M.5    Sphicas, E.6
  • 2
    • 21444442926 scopus 로고    scopus 로고
    • Radiationinduced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells
    • Ito H, Daido S, Kanzawa T, Kondo S, Kondo Y. Radiationinduced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int J Oncol 2005; 26:1401-10.
    • (2005) Int J Oncol , vol.26 , pp. 1401-1410
    • Ito, H.1    Daido, S.2    Kanzawa, T.3    Kondo, S.4    Kondo, Y.5
  • 3
    • 40449086885 scopus 로고    scopus 로고
    • Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
    • Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008; 68:1485-94.
    • (2008) Cancer Res , vol.68 , pp. 1485-1494
    • Apel, A.1    Herr, I.2    Schwarz, H.3    Rodemann, H.P.4    Mayer, A.5
  • 4
    • 67650095390 scopus 로고    scopus 로고
    • The induction of autophagy by gammaradiation contributes to the radioresistance of glioma stem cells
    • Lomonaco SL, Finniss S, Xiang C, Decarvalho A, Umansky F, Kalkanis SN, et al. The induction of autophagy by gammaradiation contributes to the radioresistance of glioma stem cells. Int J Cancer 2009; 125:717-22.
    • (2009) Int J Cancer , vol.125 , pp. 717-722
    • Lomonaco, S.L.1    Finniss, S.2    Xiang, C.3    Decarvalho, A.4    Umansky, F.5    Kalkanis, S.N.6
  • 5
    • 66449096228 scopus 로고    scopus 로고
    • The role of autophagy in sensitizing malignant glioma cells to radiation therapy
    • Zhuang W, Qin Z, Liang Z. The role of autophagy in sensitizing malignant glioma cells to radiation therapy. Acta Biochim Biophys Sin 2009; 41:341-51.
    • (2009) Acta Biochim Biophys Sin , vol.41 , pp. 341-351
    • Zhuang, W.1    Qin, Z.2    Liang, Z.3
  • 6
    • 80054038340 scopus 로고    scopus 로고
    • A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and Vitamin D
    • Wilson EN, Bristol ML, Di X, Maltese WA, Koterba K, Beckman MJ, et al. A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Horm Cancer 2011; 2:272-85.
    • (2011) Horm Cancer , vol.2 , pp. 272-285
    • Wilson, E.N.1    Bristol, M.L.2    Di, X.3    Maltese, W.A.4    Koterba, K.5    Beckman, M.J.6
  • 7
    • 84862603409 scopus 로고    scopus 로고
    • Dual functions of autophagy in the response of breast tumor cells to radiation: Cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by Vitamin D 3
    • Bristol ML, Di X, Beckman MJ, Wilson EN, Henderson SC, Maiti A, et al. Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3. Autophagy 2012; 8:739-53.
    • (2012) Autophagy , vol.8 , pp. 739-753
    • Bristol, M.L.1    Di, X.2    Beckman, M.J.3    Wilson, E.N.4    Henderson, S.C.5    Maiti, A.6
  • 8
    • 84890032905 scopus 로고    scopus 로고
    • Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling
    • Ko A, Kanehisa A, Martins I, Senovilla L, Chargari C, Dugue D, et al. Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling. Cell Death Differ 2014; 21:92-9.
    • (2014) Cell Death Differ , vol.21 , pp. 92-99
    • Ko, A.1    Kanehisa, A.2    Martins, I.3    Senovilla, L.4    Chargari, C.5    Dugue, D.6
  • 9
    • 84874735362 scopus 로고    scopus 로고
    • The tumor suppressor, p53, contributes to radiosensitivity of lung cancer cells by regulating autophagy and apoptosis
    • Cheng G, Kong D, Hou X, Liang B, He M, Liang N, et al. The tumor suppressor, p53, contributes to radiosensitivity of lung cancer cells by regulating autophagy and apoptosis. Cancer Biother Radiopharm 2013; 28:153-9.
    • (2013) Cancer Biother Radiopharm , vol.28 , pp. 153-159
    • Cheng, G.1    Kong, D.2    Hou, X.3    Liang, B.4    He, M.5    Liang, N.6
  • 10
    • 84861062884 scopus 로고    scopus 로고
    • Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments
    • Palumbo S, Pirtoli L, Tini P, Cevenini G, Calderaro F, Toscano M, et al. Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments. J Cell Biochem 2012; 113:2308-18.
    • (2012) J Cell Biochem , vol.113 , pp. 2308-2318
    • Palumbo, S.1    Pirtoli, L.2    Tini, P.3    Cevenini, G.4    Calderaro, F.5    Toscano, M.6
  • 12
    • 84867723524 scopus 로고    scopus 로고
    • Autophagy as a target for cancer therapy: New developments
    • Carew JS, Kelly KR, Nawrocki ST. Autophagy as a target for cancer therapy: new developments. Cancer Manag Res 2012; 4:357-65.
    • (2012) Cancer Manag Res , vol.4 , pp. 357-365
    • Carew, J.S.1    Kelly, K.R.2    Nawrocki, S.T.3
  • 13
    • 84887437596 scopus 로고    scopus 로고
    • Autophagy and chemotherapy resistance: A promising therapeutic target for cancer treatment
    • Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis 2013; 4:e838.
    • (2013) Cell Death Dis , vol.4 , pp. e838
    • Sui, X.1    Chen, R.2    Wang, Z.3    Huang, Z.4    Kong, N.5    Zhang, M.6
  • 14
    • 84874405394 scopus 로고    scopus 로고
    • Autophagy inhibition for chemosensitization and radiosensitization in cancer: Do the preclinical data support this therapeutic strategy?
    • Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, Gewirtz DA. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther 2013; 344:544-52.
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 544-552
    • Bristol, M.L.1    Emery, S.M.2    Maycotte, P.3    Thorburn, A.4    Chakradeo, S.5    Gewirtz, D.A.6
  • 15
    • 83755181759 scopus 로고    scopus 로고
    • Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice
    • Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P, et al. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011; 334:1573-7.
    • (2011) Science , vol.334 , pp. 1573-1577
    • Michaud, M.1    Martins, I.2    Sukkurwala, A.Q.3    Adjemian, S.4    Ma, Y.5    Pellegatti, P.6
  • 16
    • 84896993948 scopus 로고    scopus 로고
    • When cytoprotective autophagy isn't and even when it is
    • Gewirtz DA. When cytoprotective autophagy isn't...and even when it is. Autophagy 2014; 10:391-2.
    • (2014) Autophagy , vol.10 , pp. 391-392
    • Gewirtz, D.A.1
  • 17
    • 84875892111 scopus 로고    scopus 로고
    • Autophagy as a stress-response and qualitycontrol mechanism: Implications for cell injury and human disease
    • Murrow L, Debnath J. Autophagy as a stress-response and qualitycontrol mechanism: implications for cell injury and human disease. Annu Rev Pathol 2013; 8:105-37.
    • (2013) Annu Rev Pathol , vol.8 , pp. 105-137
    • Murrow, L.1    Debnath, J.2
  • 18
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005; 120:237-48.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6
  • 19
    • 78649833334 scopus 로고    scopus 로고
    • P53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation
    • Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z, Oren M. p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A 2010; 107:18511-6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18511-18516
    • Scherz-Shouval, R.1    Weidberg, H.2    Gonen, C.3    Wilder, S.4    Elazar, Z.5    Oren, M.6
  • 21
    • 79960097021 scopus 로고    scopus 로고
    • Role of autophagy in cancer prevention
    • Chen HY, White E. Role of autophagy in cancer prevention. Cancer Prev Res (Phila) 2011; 4:973-83.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 973-983
    • Chen, H.Y.1    White, E.2
  • 22
    • 84916197311 scopus 로고    scopus 로고
    • Autophagy: Detection, regulation and its role in cancer and therapy response
    • Hönscheid P, Datta K, Muders MH. Autophagy: detection, regulation and its role in cancer and therapy response. Int J Radiat Biol 2014; 25:1-8.
    • (2014) Int J Radiat Biol , vol.25 , pp. 1-8
    • Hönscheid, P.1    Datta, K.2    Muders, M.H.3
  • 23
    • 84859766593 scopus 로고    scopus 로고
    • Novel insights into the interplay between apoptosis and autophagy
    • Rikiishi H. Novel insights into the interplay between apoptosis and autophagy. Int J Cell Biol 2012; 45:2016-26.
    • (2012) Int J Cell Biol , vol.45 , pp. 2016-2026
    • Rikiishi, H.1
  • 24
    • 84879381221 scopus 로고    scopus 로고
    • Role of the crosstalk between autophagy and apoptosis in cancer
    • Su M, Mei Y, Sinha S. Role of the crosstalk between autophagy and apoptosis in cancer. J Oncol 2013; 2013:102735.
    • (2013) J Oncol , vol.2013 , pp. 102735
    • Su, M.1    Mei, Y.2    Sinha, S.3
  • 25
    • 84869214214 scopus 로고    scopus 로고
    • The autophagy-senescence connection in chemotherapy: Must tumor cells (self) eat before they sleep?
    • Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, et al. The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? J Pharmacol Exp Ther 2012; 343:763-78.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 763-778
    • Goehe, R.W.1    Di, X.2    Sharma, K.3    Bristol, M.L.4    Henderson, S.C.5    Valerie, K.6
  • 26
    • 52949152429 scopus 로고    scopus 로고
    • Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
    • Gewirtz DA, Holt SE, Elmore LW. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol 2008; 76:947-57.
    • (2008) Biochem Pharmacol , vol.76 , pp. 947-957
    • Gewirtz, D.A.1    Holt, S.E.2    Elmore, L.W.3
  • 27
    • 73449100778 scopus 로고    scopus 로고
    • Autophagy, senescence and tumor dormancy in cancer chemotherapy
    • Gewirtz DA. Autophagy, senescence and tumor dormancy in cancer chemotherapy. Autophagy 2009; 5:1232-4.
    • (2009) Autophagy , vol.5 , pp. 1232-1234
    • Gewirtz, D.A.1
  • 28
    • 80054789761 scopus 로고    scopus 로고
    • Control of the senescence-associated secretory phenotype by NF-jB promotes senescence and enhances chemosensitivity
    • Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, et al. Control of the senescence-associated secretory phenotype by NF-jB promotes senescence and enhances chemosensitivity. Genes Dev 2011; 25:2125-36.
    • (2011) Genes Dev , vol.25 , pp. 2125-2136
    • Chien, Y.1    Scuoppo, C.2    Wang, X.3    Fang, X.4    Balgley, B.5    Bolden, J.E.6
  • 29
    • 84893825919 scopus 로고    scopus 로고
    • The four faces of autophagy: Implications for cancer therapy
    • Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Cancer Res 2014; 74:647-51.
    • (2014) Cancer Res , vol.74 , pp. 647-651
    • Gewirtz, D.A.1
  • 30
    • 33750565745 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
    • Cao C, Subhawong T, Albert JM, Kim KW, Geng L, Sekhar KR, et al. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res 2006; 66:10040-7.
    • (2006) Cancer Res , vol.66 , pp. 10040-10047
    • Cao, C.1    Subhawong, T.2    Albert, J.M.3    Kim, K.W.4    Geng, L.5    Sekhar, K.R.6
  • 31
    • 35848959917 scopus 로고    scopus 로고
    • Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
    • Fujiwara K, Iwado E, Mills GB, Sawaya R, Kondo S, Kondo Y. Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int J Oncol 2007; 31:753-60.
    • (2007) Int J Oncol , vol.31 , pp. 753-760
    • Fujiwara, K.1    Iwado, E.2    Mills, G.B.3    Sawaya, R.4    Kondo, S.5    Kondo, Y.6
  • 32
    • 48249090416 scopus 로고    scopus 로고
    • Autophagy up-regulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
    • Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI, Lu B. Autophagy up-regulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008; 4:659-68.
    • (2008) Autophagy , vol.4 , pp. 659-668
    • Kim, K.W.1    Hwang, M.2    Moretti, L.3    Jaboin, J.J.4    Cha, Y.I.5    Lu, B.6
  • 33
    • 80052273362 scopus 로고    scopus 로고
    • The zinc ionophore PCI-5002 radiosensitizes non-small cell lung cancer cells by enhancing autophagic cell death
    • Kim KW, Speirs CK, Jung DK, Lu B. The zinc ionophore PCI-5002 radiosensitizes non-small cell lung cancer cells by enhancing autophagic cell death. J Thorac Oncol 2011; 6:1542-52.
    • (2011) J Thorac Oncol , vol.6 , pp. 1542-1552
    • Kim, K.W.1    Speirs, C.K.2    Jung, D.K.3    Lu, B.4
  • 34
    • 84867182336 scopus 로고    scopus 로고
    • Autophagy and ionizing radiation in tumors: The ''survive or not survive'' dilemma
    • Palumbo S, Comincini S. Autophagy and ionizing radiation in tumors: the ''survive or not survive'' dilemma. J Cell Physiol 2013; 228:1-8.
    • (2013) J Cell Physiol , vol.228 , pp. 1-8
    • Palumbo, S.1    Comincini, S.2
  • 36
    • 84910027762 scopus 로고    scopus 로고
    • Important role of autophagy in regulation of metabolic processes in health, disease and aging
    • Epub ahead of print
    • Papackova Z, Cahova M. Important role of autophagy in regulation of metabolic processes in health, disease and aging. Physiol Res 2014; Epub ahead of print. (http://www.biomed.cas. cz/physiolres/pdf/prepress/932684.pdf)
    • (2014) Physiol Res
    • Papackova, Z.1    Cahova, M.2
  • 37
    • 84861434652 scopus 로고    scopus 로고
    • Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
    • McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A 2012; 109:8253-8.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 8253-8258
    • McAfee, Q.1    Zhang, Z.2    Samanta, A.3    Levi, S.M.4    Ma, X.H.5    Piao, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.