Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects

Journal of Biological Chemistry

Volumn 290, Issue 5, 2015, Pages 2699-2714

  Wang, Huizhen ^a   Graham, Ian ^a   Hastings, Richard ^b   Gunewardena, Sumedha ^a   Brinkmeier, Michelle L ^c   Conn, P Michael ^d   Camper, Sally A ^c   Kumar, T Rajendra ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d TEXAS TECH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFECTS; FEEDBACK; FEEDBACK CONTROL; MAMMALS; PHYSIOLOGY;

BASAL LEVELS; BETA SUBUNIT; FOLLICLE STIMULATING HORMONE; HYPOTHALAMUS-PITUITARY-GONADAL AXIS; LUTEINIZING HORMONES; MUTANT MICE; POST-TRANSCRIPTIONAL REGULATIONS; TRANSCRIPTIONAL REGULATION;

RNA;

CELL MARKER; CHORIONIC GONADOTROPIN ALPHA SUBUNIT; CHORIONIC GONADOTROPIN BETA SUBUNIT; CORTICOTROPIN; DICER; ESTROGEN RECEPTOR ALPHA; FOLLITROPIN BETA SUBUNIT; GONADOTROPIN; GROWTH HORMONE; LUTEINIZING HORMONE BETA SUBUNIT; MESSENGER RNA; MICRORNA; PROGESTERONE; PROLACTIN; STEROIDOGENIC FACTOR 1; TESTOSTERONE; THYROTROPIN BETA SUBUNIT; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR SOX2; DEAD BOX PROTEIN; DICER1 PROTEIN, MOUSE; RIBONUCLEASE III;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FEMALE GENITAL SYSTEM; GENE DELETION; GENE FUNCTION; GENE REPRESSION; GERM CELL; GONADOTROPIN RELEASE; HORMONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INFERTILITY; LEYDIG CELL; MALE; MALE GENITAL SYSTEM; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; SERTOLI CELL; SEX DIFFERENCE; SUBFERTILITY; SUPEROVULATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; FERTILITY; GENETICS; GONADOTROPIN SECRETING CELL; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; RAT; REAL TIME POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; DEAD-BOX RNA HELICASES; FEMALE; FERTILITY; GONADOTROPHS; GONADOTROPINS; MALE; MICE; MICE, KNOCKOUT; MICRORNAS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RIBONUCLEASE III;

EID: 84921880096     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.621565     Document Type: Article

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