Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia

Redox Biology

Volumn 4, Issue , 2015, Pages 321-327

  Benipal, Bavneet ^a   Feinstein, Sheldon I ^a   Chatterjee, Shampa ^a   Dodia, Chandra ^a   Fisher, Aron B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Acute lung injury; Inflammation; Lipid peroxidation; MJ33; Oxidative stress

Indexed keywords

ENZYME INHIBITOR; MJ 33; PEROXIREDOXIN 6; PHOSPHOLIPASE A2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; 1-HEXADECYL-3-TRIFLUOROETHYLGLYCERO-SN-2-PHOSPHOMETHANOL; CYBB PROTEIN, MOUSE; GLYCEROPHOSPHATE; MEMBRANE PROTEIN; OXYGEN; PHOSPHOLIPASE A2 INHIBITOR; PRDX6 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; HYPEROXIA; LIPID PEROXIDATION; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NEUTROPHIL; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PROTEIN CONTENT; PROTEIN EXPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; DRUG THERAPY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

MUS;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; GENE EXPRESSION REGULATION; GLYCEROPHOSPHATES; HYPEROXIA; INJECTIONS, INTRAPERITONEAL; LIPID PEROXIDATION; LUNG; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NADPH OXIDASE; NEUTROPHILS; OXIDATIVE STRESS; OXYGEN; PEROXIREDOXIN VI; PHOSPHOLIPASE A2 INHIBITORS; PHOSPHOLIPASES A2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84921871164     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.01.011     Document Type: Article

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