NOX enzymes as drug targets

Cellular and Molecular Life Sciences

Volumn 69, Issue 14, 2012, Pages 2279-2282

  Krause, Karl Heinz ^a,b   Lambeth, David ^c   Krönke, Martin ^d,e  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

Author keywords

NADPH oxidases (NOX); NOX and disease; Peptide inhibitors; Reactive oxygen species (ROS)

Indexed keywords

ENZYME INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG; VAS 2870;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ALZHEIMER DISEASE; BRAIN ISCHEMIA; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HEARING LOSS; HUMAN; LUNG FIBROSIS; MOLECULAR EVOLUTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; REVIEW; SIGNAL TRANSDUCTION;

ENZYME INHIBITORS; HUMANS; NADPH OXIDASE; PEPTIDES; PROTEIN ISOFORMS; REACTIVE OXYGEN SPECIES;

EID: 84864362404     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1006-5     Document Type: Review

References (4)

1. Jaquet V, Scapozza L, Clark RA, Krause KH, Lambeth JD (2009) Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal 11(10):2535-2552
2. Lambeth JD, Krause KH, Clark RA (2008) NOX enzymes as novel targets for drug development. Semin Immunopathol 30(3):339-363 (Epub 2008 May 29)
3. Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87(1):245-313 (Pubitemid 46209993)
4. Lambeth JD (2004) NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4(3):181-189 (Pubitemid 38339084)