메뉴 건너뛰기




Volumn 35, Issue 3, 2015, Pages 839-846

MicroRNA-19a functions as an oncogenic microRNA in non-small cell lung cancer by targeting the suppressor of cytokine signaling 1 and mediating STAT3 activation

Author keywords

MicroRNA 19a; Non small cell lung cancer; Suppressor of cytokine signaling 1; Tumor therapy; Tumorigenesis

Indexed keywords

MICRORNA; MICRORNA 19A; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MESSENGER RNA; MIRN19 MICRORNA, HUMAN; SOCS1 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING;

EID: 84921794197     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2071     Document Type: Article
Times cited : (31)

References (51)
  • 2
    • 79957520182 scopus 로고    scopus 로고
    • Health-related quality of life in non-small-cell lung cancer: An update of a systematic review on methodologic issues in randomized controlled trials
    • Claassens L, van Meerbeeck J, Coens C, et al: Health-related quality of life in non-small-cell lung cancer: an update of a systematic review on methodologic issues in randomized controlled trials. J Clin Oncol 29: 2104-2120, 2011.
    • (2011) J Clin Oncol , vol.29 , pp. 2104-2120
    • Claassens, L.1    Van Meerbeeck, J.2    Coens, C.3
  • 3
    • 77950498821 scopus 로고    scopus 로고
    • Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer
    • Hu Z, Chen X, Zhao Y, et al: Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol 28: 1721-1726, 2010.
    • (2010) J Clin Oncol , vol.28 , pp. 1721-1726
    • Hu, Z.1    Chen, X.2    Zhao, Y.3
  • 4
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355: 2542-2550, 2006.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 5
    • 0038207864 scopus 로고    scopus 로고
    • Integration of targeted therapies in gemcitabine chemotherapy regimens
    • Blumenschein GR Jr and Herbst RS: Integration of targeted therapies in gemcitabine chemotherapy regimens. Clin Lung Cancer 4: 217-223, 2003.
    • (2003) Clin Lung Cancer , vol.4 , pp. 217-223
    • Blumenschein, G.R.1    Herbst, R.S.2
  • 6
    • 36049026182 scopus 로고    scopus 로고
    • Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
    • Cabebe E and Wakelee H: Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr Treat Options Oncol 8: 15-27, 2007.
    • (2007) Curr Treat Options Oncol , vol.8 , pp. 15-27
    • Cabebe, E.1    Wakelee, H.2
  • 8
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 9
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: MicroRNA biogenesis pathways and their regulation
    • Winter J, Jung S, Keller S, Gregory RI and Diederichs S: Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11: 228-234, 2009.
    • (2009) Nat Cell Biol , vol.11 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 11
    • 79955715540 scopus 로고    scopus 로고
    • MicroRNAs (miRNAs) in cancer invasion and metastasis: Therapeutic approaches based on metastasis-related miRNAs
    • Aigner A: MicroRNAs (miRNAs) in cancer invasion and metastasis: therapeutic approaches based on metastasis-related miRNAs. J Mol Med (Berl) 89: 445-457, 2011.
    • (2011) J Mol Med (Berl) , vol.89 , pp. 445-457
    • Aigner, A.1
  • 12
    • 78549249141 scopus 로고    scopus 로고
    • MicroRNAs, cancer and cancer stem cells
    • Zimmerman AL and Wu S: MicroRNAs, cancer and cancer stem cells. Cancer Lett 300: 10-19, 2011.
    • (2011) Cancer Lett , vol.300 , pp. 10-19
    • Zimmerman, A.L.1    Wu, S.2
  • 13
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 14
    • 84897018932 scopus 로고    scopus 로고
    • Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
    • Wang P, Chen L, Zhang J, et al: Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. Oncogene 33: 514-524, 2014.
    • (2014) Oncogene , vol.33 , pp. 514-524
    • Wang, P.1    Chen, L.2    Zhang, J.3
  • 15
    • 72049101611 scopus 로고    scopus 로고
    • Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras
    • Oh JS, Kim JJ, Byun JY and Kim IA: Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras. Int J Radiat Oncol Biol Phys 76: 5-8, 2010.
    • (2010) Int J Radiat Oncol Biol Phys , vol.76 , pp. 5-8
    • Oh, J.S.1    Kim, J.J.2    Byun, J.Y.3    Kim, I.A.4
  • 16
    • 84878110643 scopus 로고    scopus 로고
    • The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL
    • Wang P, Zhuang L, Zhang J, et al: The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL. Mol Oncol 7: 334-345, 2013.
    • (2013) Mol Oncol , vol.7 , pp. 334-345
    • Wang, P.1    Zhuang, L.2    Zhang, J.3
  • 17
    • 39849095077 scopus 로고    scopus 로고
    • E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer
    • Petrocca F, Visone R, Onelli MR, et al : E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13: 272-286, 2008.
    • (2008) Cancer Cell , vol.13 , pp. 272-286
    • Petrocca, F.1    Visone, R.2    Onelli, M.R.3
  • 18
    • 84897388025 scopus 로고    scopus 로고
    • MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1
    • Wu Q, Yang Z, An Y, et al: MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1. Cell Death Dis 5: e1144, 2014.
    • (2014) Cell Death Dis , vol.5 , pp. e1144
    • Wu, Q.1    Yang, Z.2    An, Y.3
  • 19
    • 84861682346 scopus 로고    scopus 로고
    • MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5
    • Xu XM, Wang XB, Chen MM, et al: MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. Cancer Lett 322: 148-158, 2012.
    • (2012) Cancer Lett , vol.322 , pp. 148-158
    • Xu, X.M.1    Wang, X.B.2    Chen, M.M.3
  • 20
    • 84879793753 scopus 로고    scopus 로고
    • MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion
    • Yu G, Li H, Wang X, et al: MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. Mol Cell Biochem 380: 239-247, 2013.
    • (2013) Mol Cell Biochem , vol.380 , pp. 239-247
    • Yu, G.1    Li, H.2    Wang, X.3
  • 21
    • 84878300205 scopus 로고    scopus 로고
    • Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancer
    • Lin Q, Chen T, Lin Q, Lin G, et al: Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancer. J Surg Oncol 107: 767-771, 2013.
    • (2013) J Surg Oncol , vol.107 , pp. 767-771
    • Lin, Q.1    Chen, T.2    Lin, Q.3    Lin, G.4
  • 22
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - new molecular targets come of age
    • Yu H and Jove R: The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 4: 97-105, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 23
    • 81555210946 scopus 로고    scopus 로고
    • Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis
    • Tian M, Wan Y, Tang J, et al: Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis. Cancer Biol Ther 12: 896-907, 2011.
    • (2011) Cancer Biol Ther , vol.12 , pp. 896-907
    • Tian, M.1    Wan, Y.2    Tang, J.3
  • 24
    • 84862779331 scopus 로고    scopus 로고
    • Role of SOCS1 in tumor progression and therapeutic application
    • Zhang J, Li H, Yu JP, Wang SE and Ren XB: Role of SOCS1 in tumor progression and therapeutic application. Int J Cancer 130: 1971-1980, 2012.
    • (2012) Int J Cancer , vol.130 , pp. 1971-1980
    • Zhang, J.1    Li, H.2    Yu, J.P.3    Wang, S.E.4    Ren, X.B.5
  • 25
    • 84880591421 scopus 로고    scopus 로고
    • Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1
    • Huang C, Li H, Wu W, Jiang T and Qiu Z: Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1. Oncol Rep 30: 1223-1230, 2013.
    • (2013) Oncol Rep , vol.30 , pp. 1223-1230
    • Huang, C.1    Li, H.2    Wu, W.3    Jiang, T.4    Qiu, Z.5
  • 26
    • 84869448346 scopus 로고    scopus 로고
    • SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway
    • Cittadini A, Monti MG, Iaccarino G, et al: SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway. Cardiovasc Res 96: 381-390, 2012.
    • (2012) Cardiovasc Res , vol.96 , pp. 381-390
    • Cittadini, A.1    Monti, M.G.2    Iaccarino, G.3
  • 27
    • 84871997077 scopus 로고    scopus 로고
    • Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma
    • Liu L, Li W, Wei X, et al: Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma. Gene Ther 20: 84-92, 2013.
    • (2013) Gene Ther , vol.20 , pp. 84-92
    • Liu, L.1    Li, W.2    Wei, X.3
  • 28
    • 84896704806 scopus 로고    scopus 로고
    • MicroRNA-17, microRNA-18a, and microRNA-19a are prognostic indicators in esophageal squamous cell carcinoma
    • Xu XL, Jiang YH, Feng JG, et al: MicroRNA-17, microRNA-18a, and microRNA-19a are prognostic indicators in esophageal squamous cell carcinoma. Ann Thorac Surg 97: 1037-1045, 2014.
    • (2014) Ann Thorac Surg , vol.97 , pp. 1037-1045
    • Xu, X.L.1    Jiang, Y.H.2    Feng, J.G.3
  • 29
    • 84902301976 scopus 로고    scopus 로고
    • Oncogenic MicroRNAs: MiR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serum
    • Sochor M, Basova P, Pesta M, et al: Oncogenic MicroRNAs: miR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serum. BMC Cancer 14: 448, 2014.
    • (2014) BMC Cancer , vol.14 , pp. 448
    • Sochor, M.1    Basova, P.2    Pesta, M.3
  • 30
    • 59649105246 scopus 로고    scopus 로고
    • MicroRNAs expressed during lung cancer development are expressed in human pseudoglandular lung embryogenesis
    • Navarro A, Marrades RM, Vinolas N, et al: MicroRNAs expressed during lung cancer development are expressed in human pseudoglandular lung embryogenesis. Oncology 76: 162-169, 2009.
    • (2009) Oncology , vol.76 , pp. 162-169
    • Navarro, A.1    Marrades, R.M.2    Vinolas, N.3
  • 31
    • 84893345623 scopus 로고    scopus 로고
    • Serum miR-19a predicts resistance to FOLFOX chemotherapy in advanced colorectal cancer cases
    • Chen Q, Xia HW, Ge XJ, et al: Serum miR-19a predicts resistance to FOLFOX chemotherapy in advanced colorectal cancer cases. Asian Pac J Cancer Prev 14: 7421-7426, 2013.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 7421-7426
    • Chen, Q.1    Xia, H.W.2    Ge, X.J.3
  • 32
    • 84887140184 scopus 로고    scopus 로고
    • Silencing of the miR-17-92 cluster family inhibits medulloblastoma progression
    • Murphy BL, Obad S, Bihannic L, et al : Silencing of the miR-17-92 cluster family inhibits medulloblastoma progression. Cancer Res 73: 7068-7078, 2013.
    • (2013) Cancer Res , vol.73 , pp. 7068-7078
    • Murphy, B.L.1    Obad, S.2    Bihannic, L.3
  • 33
    • 84908500692 scopus 로고    scopus 로고
    • Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation
    • Li X, Xie W, Xie C, et al : Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation. Phytother Res 28: 1553-1560, 2014.
    • (2014) Phytother Res , vol.28 , pp. 1553-1560
    • Li, X.1    Xie, W.2    Xie, C.3
  • 34
    • 84891811925 scopus 로고    scopus 로고
    • MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression
    • Wu TY, Zhang TH, Qu LM, et al: MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression. Int J Clin Exp Pathol 7: 56-63, 2013.
    • (2013) Int J Clin Exp Pathol , vol.7 , pp. 56-63
    • Wu, T.Y.1    Zhang, T.H.2    Qu, L.M.3
  • 35
    • 84880488920 scopus 로고    scopus 로고
    • MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN
    • Wang F, Li T, Zhang B, et al: MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN. Biochem Biophys Res Commun 434: 688-694, 2013.
    • (2013) Biochem Biophys Res Commun , vol.434 , pp. 688-694
    • Wang, F.1    Li, T.2    Zhang, B.3
  • 36
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • Krebs DL and Hilton DJ: SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19: 378-387, 2001.
    • (2001) Stem Cells , vol.19 , pp. 378-387
    • Krebs, D.L.1    Hilton, D.J.2
  • 37
    • 0034082217 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling pathways
    • Yasukawa H, Sasaki A and Yoshimura A: Negative regulation of cytokine signaling pathways. Annu Rev Immunol 18: 143-164, 2000.
    • (2000) Annu Rev Immunol , vol.18 , pp. 143-164
    • Yasukawa, H.1    Sasaki, A.2    Yoshimura, A.3
  • 38
    • 33646836481 scopus 로고    scopus 로고
    • SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation
    • He Y, Zhang W, Zhang R, Zhang H and Min W: SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. J Biol Chem 281: 5559-5566, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 5559-5566
    • He, Y.1    Zhang, W.2    Zhang, R.3    Zhang, H.4    Min, W.5
  • 39
    • 10744223505 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    • Hanada T, Yoshida H, Kato S, et al: Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19: 437-450, 2003.
    • (2003) Immunity , vol.19 , pp. 437-450
    • Hanada, T.1    Yoshida, H.2    Kato, S.3
  • 40
    • 32044451547 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved
    • Chinen T, Kobayashi T, Ogata H, et al: Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 130: 373-388, 2006.
    • (2006) Gastroenterology , vol.130 , pp. 373-388
    • Chinen, T.1    Kobayashi, T.2    Ogata, H.3
  • 41
    • 84908051990 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signalling in human neoplasms
    • Sasi W, Sharma AK and Mokbel K: The role of suppressors of cytokine signalling in human neoplasms. Mol Biol Int 2014: 630797, 2014.
    • (2014) Mol Biol Int , vol.2014 , pp. 630797
    • Sasi, W.1    Sharma, A.K.2    Mokbel, K.3
  • 42
    • 84855451663 scopus 로고    scopus 로고
    • Epigenetic alteration of the SOCS1 gene in hepatocellular carcinoma
    • Chu PY, Yeh CM, Hsu NC, et al: Epigenetic alteration of the SOCS1 gene in hepatocellular carcinoma. Swiss Med Wkly 140: w13065, 2010.
    • (2010) Swiss Med Wkly , vol.140
    • Chu, P.Y.1    Yeh, C.M.2    Hsu, N.C.3
  • 43
    • 65649134366 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases
    • Neuwirt H, Puhr M, Santer FR, et al: Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases. Am J Pathol 174: 1921-1930, 2009.
    • (2009) Am J Pathol , vol.174 , pp. 1921-1930
    • Neuwirt, H.1    Puhr, M.2    Santer, F.R.3
  • 44
    • 18344415251 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers
    • Komazaki T, Nagai H, Emi M, et al: Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers. Jpn J Clin Oncol 34: 191-194, 2004.
    • (2004) Jpn J Clin Oncol , vol.34 , pp. 191-194
    • Komazaki, T.1    Nagai, H.2    Emi, M.3
  • 45
    • 77950650093 scopus 로고    scopus 로고
    • Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells
    • Lesinski GB, Zimmerer JM, Kreiner M, et al: Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells. BMC Cancer 10: 142, 2010.
    • (2010) BMC Cancer , vol.10 , pp. 142
    • Lesinski, G.B.1    Zimmerer, J.M.2    Kreiner, M.3
  • 46
    • 34250347991 scopus 로고    scopus 로고
    • SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells
    • Zitzmann K, Brand S, De Toni EN, et al: SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells. Cancer Res 67: 5025-5032, 2007.
    • (2007) Cancer Res , vol.67 , pp. 5025-5032
    • Zitzmann, K.1    Brand, S.2    De Toni, E.N.3
  • 47
    • 79960890780 scopus 로고    scopus 로고
    • JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer
    • Zhao M, Gao FH, Wang JY, et al : JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer. Lung Cancer 73: 366-374, 2011.
    • (2011) Lung Cancer , vol.73 , pp. 366-374
    • Zhao, M.1    Gao, F.H.2    Wang, J.Y.3
  • 48
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9: 798-809, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 49
    • 84864136013 scopus 로고    scopus 로고
    • Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells
    • Souma Y, Nishida T, Serada S, et al: Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells. Int J Cancer 131: 1287-1296, 2012.
    • (2012) Int J Cancer , vol.131 , pp. 1287-1296
    • Souma, Y.1    Nishida, T.2    Serada, S.3
  • 50
    • 84896900555 scopus 로고    scopus 로고
    • Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway
    • Xu Y, Xu X, Gao X, Chen H and Geng L: Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway. Int Immunopharmacol 19: 327-333, 2014.
    • (2014) Int Immunopharmacol , vol.19 , pp. 327-333
    • Xu, Y.1    Xu, X.2    Gao, X.3    Chen, H.4    Geng, L.5
  • 51
    • 84886770212 scopus 로고    scopus 로고
    • Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells
    • Shimada K, Serada S, Fujimoto M, et al: Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells. Cancer Sci 104: 1483-1491, 2013.
    • (2013) Cancer Sci , vol.104 , pp. 1483-1491
    • Shimada, K.1    Serada, S.2    Fujimoto, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.