Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis

Cancer Biology and Therapy

Volumn 12, Issue 10, 2011, Pages 896-907

  Tian, Maolin ^a,d   Wan, Yuanlian ^a   Tang, Jianqiang ^a   Li, Hui ^a   Yu, Ge ^a   Zhu, Jing ^a   Ji, Shiqi ^a   Guo, Hui ^a   Zhang, Nan ^a   Li, Weiren ^a   Gai, Junwei ^a   Wang, Lei ^a   Dai, Lifang ^a   Liu, Die ^a   Lei, Liandi ^b   Zhu, Shigong ^c  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Colon cancer; Hepatic metastasis; MMPs; PERK; Tissue factor; Unfolded protein response (UPR)

Indexed keywords

MATRIX METALLOPROTEINASE; THROMBOPLASTIN;

ADULT; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CELL MIGRATION; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOREACTIVITY; IN VITRO STUDY; LIVER METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 81555210946     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.10.17679     Document Type: Article

References (22)

1. Cheng KC, Yeung YP, Lau PY, Meng WC. Surveillance and outcome of liver metastasis in patients with colorectal cancer who had undergone curative-intent operation. Hong Kong Med J 2008; 14:896-907; PMID:19060341
2. Sørbye H, Braendengen M, Balteskard L. Palliative chemotherapy and radiotherapy for metastatic colorectal cancer. Tidsskr Nor Laegeforen 2008; 128:194-7; PMID:18202732
3. Zucker S, Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev 2004; 23:101-17; PMID:15000152; http://dx.doi.org/10.1023/A:1025867130437
4. Kenific CM, Thorburn A, Debnath J. Autophagy and metastasis: another double-edged sword. Curr Opin Cell Biol 2010; 22:241-5; PMID:19945838; http://dx.doi.org/10.1016/j.ceb.2009.10.008
5. Klionsky DJ, Cregg JM, Dunn WA, Jr., Emr SD, Sakai Y, Sandoval IV, et al. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5:539-45; PMID:14536056; http://dx.doi.org/10.1016/S1534-5807(03)00296-X
6. Kang MR, Kim MS, Oh JE, Kim YR, Song SY, Kim SS, et al. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. J Pathol 2009; 217:702-6; PMID:19197948; http://dx.doi.org/10.1002/path.2509
7. Noda NN, Kumeta H, Nakatogawa H, Satoo K, Adachi W, Ishii J, et al. Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells 2008; 13:1211-8; PMID:19021777; http://dx.doi.org/10.1111/j.1365- 2443.2008.01238.x
8. Lee CJ, Chandrasekaran V, Wu S, Duke RE, Pedersen LG. Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex. Thromb Res 2010; 125(Suppl1):S7-10; PMID:20156644; http://dx.doi.org/10.1016/j.thromres.2010.01.022
9. Zerbib P, Grimonprez A, Corseaux D, Mouquet F, Nunes B, Petersen LC, et al. Inhibition of tissue factor-factor VIIa proteolytic activity blunts hepatic metastasis in colorectal cancer. J Surg Res 2009; 153:239-45; PMID:19062044; http://dx.doi.org/10.1016/j.jss.2008.05.014
10. Wang L, Yu C, Lu Y, He P, Guo J, Zhang C, et al. TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis. Apoptosis 2007; 12: 1489-502; PMID:17492404; http://dx.doi.org/10.1007/s10495-007-0073-9
11. Mukherjee S, Roth MJ, Dawsey SM, Yan W, Rodriguez-Canales J, Erickson HS, et al. Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma. J Transl Med 2010; 8:91; PMID:20920372; http://dx.doi.org/10. 1186/1479-5876-8-91
12. So MK, Xu C, Loening AM, Gambhir SS, Rao J. Self-illuminating quantum dot conjugates for in vivo imaging. Nat Biotechnol 2006; 24:339-43; PMID: 16501578; http://dx.doi.org/10.1038/nbt1188
13. Zhang X, Yu H, Lou JR, Zheng J, Zhu H, Popescu NI, et al. MicroRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem 2011; 286:1429-35; PMID:21059650; http://dx.doi.org/10.1074/jbc.M110.146530
14. Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26:9220-31; PMID:17030611; http://dx.doi.org/10.1128/MCB.01453- 06
15. Rak J, Milsom C, May L, Klement P, Yu J. Tissue factor in cancer and angiogenesis: the molecular link between genetic tumor progression, tumor neovascularization, and cancer coagulopathy. Semin Thromb Hemost 2006; 32:54-70; PMID:16479463; http://dx.doi.org/10.1055/s-2006-933341
16. Scheper GC, van der Knaap MS, Proud CG. Translation matters: protein synthesis defects in inherited disease. Nat Rev Genet 2007; 8:711-23; PMID: 17680008; http://dx.doi.org/10.1038/nrg2142
17. Pavitt GD, Proud CG. Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Biochem Soc Trans 2009; 37:1298-310; PMID: 19909266; http://dx.doi.org/10.1042/BST0371298
18. Lin W, Popko B. Endoplasmic reticulum stress in disorders of myelinating cells. Nat Neurosci 2009; 12: 379-85; PMID:19287390; http://dx.doi.org/10.1038/ nn.2273
19. Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest 2010; 120: 127-41; PMID:20038797; http://dx.doi.org/10.1172/JCI40027
20. Satoo K, Noda NN, Kumeta H, Fujioka Y, Mizushima N, Ohsumi Y, et al. The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J 2009; 28:1341-50; PMID:19322194; http://dx.doi.org/10.1038/emboj.2009.80
21. Kang MR, Kim MS, Oh JE, Kim YR, Song SY, Kim SS, et al. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. J Pathol 2009; 217:702-6; PMID:19197948; http://dx.doi.org/10.1002/path.2509
22. Deng L, Feng J, Broaddus RR. The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress. Cell Death Dis 2010; 1:e32; PMID:21072319; http://dx.doi.org/10.1038/cddis.2010.9