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Volumn 10, Issue , 2010, Pages

Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERFERON; RETROVIRUS VECTOR; SMALL INTERFERING RNA; STAT1 PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; TYROSINE; ALPHA2B INTERFERON; SOCS1 PROTEIN, HUMAN; SOCS3 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN;

EID: 77950650093     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-142     Document Type: Article
Times cited : (53)

References (44)
  • 1
    • 33750321707 scopus 로고    scopus 로고
    • Interferons, immunity and cancer immunoediting
    • 10.1038/nri1961, 17063185
    • Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol 2006, 6(11):836-848. 10.1038/nri1961, 17063185.
    • (2006) Nat Rev Immunol , vol.6 , Issue.11 , pp. 836-848
    • Dunn, G.P.1    Koebel, C.M.2    Schreiber, R.D.3
  • 3
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice
    • 10.1073/pnas.95.13.7556, 22681, 9636188
    • Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, Schreiber RD. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 1998, 95(13):7556-7561. 10.1073/pnas.95.13.7556, 22681, 9636188.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.13 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3    Stockert, E.4    Aguet, M.5    Old, L.J.6    Schreiber, R.D.7
  • 4
    • 0037217219 scopus 로고    scopus 로고
    • Temozolomide in combination with interferon alpha-2b in patients with metastatic melanoma: a phase I dose-escalation study
    • 10.1002/cncr.11041, 12491513
    • Agarwala SS, Kirkwood JM. Temozolomide in combination with interferon alpha-2b in patients with metastatic melanoma: a phase I dose-escalation study. Cancer 2003, 97(1):121-127. 10.1002/cncr.11041, 12491513.
    • (2003) Cancer , vol.97 , Issue.1 , pp. 121-127
    • Agarwala, S.S.1    Kirkwood, J.M.2
  • 6
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684
    • Kirkwood JM, Strawderman MH, Ernstoff MS, Smith TJ, Borden EC, Blum RH. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. Journal of Clinical Oncology 1996, 14(1):7-17.
    • (1996) Journal of Clinical Oncology , vol.14 , Issue.1 , pp. 7-17
    • Kirkwood, J.M.1    Strawderman, M.H.2    Ernstoff, M.S.3    Smith, T.J.4    Borden, E.C.5    Blum, R.H.6
  • 7
    • 0022633528 scopus 로고
    • Interferons in the treatment of malignant melanoma. A review of recent trials
    • 10.1002/1097-0142(19860415)57:8+<1675::AID-CNCR2820571307>3.0.CO;2-I, 3512072
    • Legha SS. Interferons in the treatment of malignant melanoma. A review of recent trials. Cancer 1986, 57(8 Suppl):1675-1677. 10.1002/1097-0142(19860415)57:8+<1675::AID-CNCR2820571307>3.0.CO;2-I, 3512072.
    • (1986) Cancer , vol.57 , Issue.8 SUPPL , pp. 1675-1677
    • Legha, S.S.1
  • 11
    • 33745989541 scopus 로고    scopus 로고
    • Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses
    • 10.1200/JCO.2005.05.2498, 16809739
    • Moschos SJ, Edington HD, Land SR, Rao UN, Jukic D, Shipe-Spotloe J, Kirkwood JM. Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses. J Clin Oncol 2006, 24(19):3164-3171. 10.1200/JCO.2005.05.2498, 16809739.
    • (2006) J Clin Oncol , vol.24 , Issue.19 , pp. 3164-3171
    • Moschos, S.J.1    Edington, H.D.2    Land, S.R.3    Rao, U.N.4    Jukic, D.5    Shipe-Spotloe, J.6    Kirkwood, J.M.7
  • 12
    • 0037061736 scopus 로고    scopus 로고
    • Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells
    • 10.1038/sj.onc.1205341, 11971185
    • Huang S, Bucana CD, Van Arsdall M, Fidler IJ. Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells. Oncogene 2002, 21(16):2504-2512. 10.1038/sj.onc.1205341, 11971185.
    • (2002) Oncogene , vol.21 , Issue.16 , pp. 2504-2512
    • Huang, S.1    Bucana, C.D.2    Van Arsdall, M.3    Fidler, I.J.4
  • 13
    • 0034658690 scopus 로고    scopus 로고
    • Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
    • 10.1038/sj.onc.1203480, 10851049
    • Levy DE, Gilliland DG. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 2000, 19(21):2505-2510. 10.1038/sj.onc.1203480, 10851049.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2505-2510
    • Levy, D.E.1    Gilliland, D.G.2
  • 14
    • 0033973215 scopus 로고    scopus 로고
    • Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha
    • 10.1002/(SICI)1097-0215(20000301)85:5<720::AID-IJC20>3.0.CO;2-O, 10699955
    • Pansky A, Hildebrand P, Fasler-Kan E, Baselgia L, Ketterer S, Beglinger C, Heim MH. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha. Int J Cancer 2000, 85(5):720-725. 10.1002/(SICI)1097-0215(20000301)85:5<720::AID-IJC20>3.0.CO;2-O, 10699955.
    • (2000) Int J Cancer , vol.85 , Issue.5 , pp. 720-725
    • Pansky, A.1    Hildebrand, P.2    Fasler-Kan, E.3    Baselgia, L.4    Ketterer, S.5    Beglinger, C.6    Heim, M.H.7
  • 16
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • 10.1126/science.8197455, 8197455
    • Darnell JE, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264(5164):1415-1421. 10.1126/science.8197455, 8197455.
    • (1994) Science , vol.264 , Issue.5164 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 17
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferon-mediated signalling
    • 10.1038/nri1604, 15864272
    • Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 2005, 5(5):375-386. 10.1038/nri1604, 15864272.
    • (2005) Nat Rev Immunol , vol.5 , Issue.5 , pp. 375-386
    • Platanias, L.C.1
  • 18
    • 34548823257 scopus 로고    scopus 로고
    • Melanoma cells exhibit variable signal transducer and activator of transcription 1 phosphorylation and a reduced response to IFN-alpha compared with immune effector cells
    • 10.1158/1078-0432.CCR-06-3092, 17785551
    • Lesinski GB, Trefry J, Brasdovich M, Kondadasula SV, Sackey K, Zimmerer JM, Chaudhury AR, Yu L, Zhang X, Crespin TR, et al. Melanoma cells exhibit variable signal transducer and activator of transcription 1 phosphorylation and a reduced response to IFN-alpha compared with immune effector cells. Clin Cancer Res 2007, 13(17):5010-5019. 10.1158/1078-0432.CCR-06-3092, 17785551.
    • (2007) Clin Cancer Res , vol.13 , Issue.17 , pp. 5010-5019
    • Lesinski, G.B.1    Trefry, J.2    Brasdovich, M.3    Kondadasula, S.V.4    Sackey, K.5    Zimmerer, J.M.6    Chaudhury, A.R.7    Yu, L.8    Zhang, X.9    Crespin, T.R.10
  • 19
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • 398400, 7796808
    • Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. Embo J 1995, 14(12):2816-2826. 398400, 7796808.
    • (1995) Embo J , vol.14 , Issue.12 , pp. 2816-2826
    • Yoshimura, A.1    Ohkubo, T.2    Kiguchi, T.3    Jenkins, N.A.4    Gilbert, D.J.5    Copeland, N.G.6    Hara, T.7    Miyajima, A.8
  • 20
    • 0036595049 scopus 로고    scopus 로고
    • Suppressors of cytokine signalling (SOCS) in the immune system
    • Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2002, 2(6):410-416.
    • (2002) Nat Rev Immunol , vol.2 , Issue.6 , pp. 410-416
    • Alexander, W.S.1
  • 21
    • 0347093460 scopus 로고    scopus 로고
    • Inhibitors of cytokine signal transduction
    • 10.1074/jbc.R300030200, 14607831
    • Wormald S, Hilton DJ. Inhibitors of cytokine signal transduction. J Biol Chem 2004, 279(2):821-824. 10.1074/jbc.R300030200, 14607831.
    • (2004) J Biol Chem , vol.279 , Issue.2 , pp. 821-824
    • Wormald, S.1    Hilton, D.J.2
  • 22
    • 4644278484 scopus 로고    scopus 로고
    • Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma
    • 10.1111/j.0022-202X.2004.23408.x, 15373779
    • Li Z, Metze D, Nashan D, Muller-Tidow C, Serve HL, Poremba C, Luger TA, Bohm M. Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma. J Invest Dermatol 2004, 123(4):737-745. 10.1111/j.0022-202X.2004.23408.x, 15373779.
    • (2004) J Invest Dermatol , vol.123 , Issue.4 , pp. 737-745
    • Li, Z.1    Metze, D.2    Nashan, D.3    Muller-Tidow, C.4    Serve, H.L.5    Poremba, C.6    Luger, T.A.7    Bohm, M.8
  • 23
    • 34447333719 scopus 로고    scopus 로고
    • Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells
    • 10.1038/sj.bjc.6603849, 2360293, 17579625
    • Fojtova M, Boudny V, Kovarik A, Lauerova L, Adamkova L, Souckova K, Jarkovsky J, Kovarik J. Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells. Br J Cancer 2007, 97(2):231-237. 10.1038/sj.bjc.6603849, 2360293, 17579625.
    • (2007) Br J Cancer , vol.97 , Issue.2 , pp. 231-237
    • Fojtova, M.1    Boudny, V.2    Kovarik, A.3    Lauerova, L.4    Adamkova, L.5    Souckova, K.6    Jarkovsky, J.7    Kovarik, J.8
  • 24
    • 34147147504 scopus 로고    scopus 로고
    • Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line
    • 10.1158/1541-7786.MCR-06-0274, 17374732
    • Komyod W, Bohm M, Metze D, Heinrich PC, Behrmann I. Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line. Mol Cancer Res 2007, 5(3):271-281. 10.1158/1541-7786.MCR-06-0274, 17374732.
    • (2007) Mol Cancer Res , vol.5 , Issue.3 , pp. 271-281
    • Komyod, W.1    Bohm, M.2    Metze, D.3    Heinrich, P.C.4    Behrmann, I.5
  • 25
    • 33646973354 scopus 로고    scopus 로고
    • Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines
    • 10.1097/00008390-200512000-00001, 16314732
    • Kovarik A, Fojtova M, Boudny V, Adamkova L, Lauerova L, Kovarik J. Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines. Melanoma Res 2005, 15(6):481-488. 10.1097/00008390-200512000-00001, 16314732.
    • (2005) Melanoma Res , vol.15 , Issue.6 , pp. 481-488
    • Kovarik, A.1    Fojtova, M.2    Boudny, V.3    Adamkova, L.4    Lauerova, L.5    Kovarik, J.6
  • 27
    • 0034647541 scopus 로고    scopus 로고
    • Regulation of SOCS-1 expression by translational repression
    • 10.1074/jbc.M910087199, 10764816
    • Gregorieff A, Pyronnet S, Sonenberg N, Veillette A. Regulation of SOCS-1 expression by translational repression. J Biol Chem 2000, 275(28):21596-21604. 10.1074/jbc.M910087199, 10764816.
    • (2000) J Biol Chem , vol.275 , Issue.28 , pp. 21596-21604
    • Gregorieff, A.1    Pyronnet, S.2    Sonenberg, N.3    Veillette, A.4
  • 28
    • 4444226259 scopus 로고    scopus 로고
    • Multiparametric flow cytometric analysis of inter-patient variation in STAT1 phosphorylation following interferon alfa immunotherapy
    • Lesinski GB, Kondadasula SV, Crespin T, Shen L, Kendra K, Walker MJ, Carson WE. Multiparametric flow cytometric analysis of inter-patient variation in STAT1 phosphorylation following interferon alfa immunotherapy. J Natl Cancer Inst 2004, 96:1331-1342.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1331-1342
    • Lesinski, G.B.1    Kondadasula, S.V.2    Crespin, T.3    Shen, L.4    Kendra, K.5    Walker, M.J.6    Carson, W.E.7
  • 29
    • 2942555182 scopus 로고    scopus 로고
    • IL-12 pretreatments enhance IFN-alpha-induced Janus kinase-STAT signaling and potentiate the antitumor effects of IFN-alpha in a murine model of malignant melanoma
    • Lesinski GB, Badgwell B, Zimmerer J, Crespin T, Hu Y, Abood G, Carson WE. IL-12 pretreatments enhance IFN-alpha-induced Janus kinase-STAT signaling and potentiate the antitumor effects of IFN-alpha in a murine model of malignant melanoma. J Immunol 2004, 172(12):7368-7376.
    • (2004) J Immunol , vol.172 , Issue.12 , pp. 7368-7376
    • Lesinski, G.B.1    Badgwell, B.2    Zimmerer, J.3    Crespin, T.4    Hu, Y.5    Abood, G.6    Carson, W.E.7
  • 30
    • 12944299796 scopus 로고    scopus 로고
    • Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector
    • 10.1016/j.jim.2004.11.012, 15680156
    • Becknell B, Trotta R, Yu J, Ding W, Mao HC, Hughes T, Marburger T, Caligiuri MA. Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector. J Immunol Methods 2005, 296(1-2):115-123. 10.1016/j.jim.2004.11.012, 15680156.
    • (2005) J Immunol Methods , vol.296 , Issue.1-2 , pp. 115-123
    • Becknell, B.1    Trotta, R.2    Yu, J.3    Ding, W.4    Mao, H.C.5    Hughes, T.6    Marburger, T.7    Caligiuri, M.A.8
  • 31
    • 34247107684 scopus 로고    scopus 로고
    • IFN-alpha-induced signal transduction, gene expression, and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins
    • Zimmerer JM, Lesinski GB, Kondadasula SV, Karpa VI, Lehman A, Raychaudhury A, Becknell B, Carson WE. IFN-alpha-induced signal transduction, gene expression, and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins. J Immunol 2007, 178(8):4832-4845.
    • (2007) J Immunol , vol.178 , Issue.8 , pp. 4832-4845
    • Zimmerer, J.M.1    Lesinski, G.B.2    Kondadasula, S.V.3    Karpa, V.I.4    Lehman, A.5    Raychaudhury, A.6    Becknell, B.7    Carson, W.E.8
  • 32
    • 0000882795 scopus 로고
    • Extension of multiple range tests to group means with unequal numbers of replications
    • Kramer C. Extension of multiple range tests to group means with unequal numbers of replications. Biometrics 1956, 12:309-310.
    • (1956) Biometrics , vol.12 , pp. 309-310
    • Kramer, C.1
  • 33
    • 52949096859 scopus 로고    scopus 로고
    • The function of Stat3 in tumor cells and their microenvironment
    • 10.1016/j.semcdb.2008.06.005, 18621135
    • Groner B, Lucks P, Borghouts C. The function of Stat3 in tumor cells and their microenvironment. Semin Cell Dev Biol 2008, 19(4):341-350. 10.1016/j.semcdb.2008.06.005, 18621135.
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.4 , pp. 341-350
    • Groner, B.1    Lucks, P.2    Borghouts, C.3
  • 34
    • 17144365840 scopus 로고    scopus 로고
    • IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression
    • Dunn GP, Sheehan KC, Old LJ, Schreiber RD. IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression. Cancer Res 2005, 65(8):3447-3453.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3447-3453
    • Dunn, G.P.1    Sheehan, K.C.2    Old, L.J.3    Schreiber, R.D.4
  • 35
    • 0030712998 scopus 로고    scopus 로고
    • Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma
    • 10.1074/jbc.272.45.28779, 9353349
    • Wong LH, Krauer KG, Hatzinisiriou I, Estcourt MJ, Hersey P, Tam ND, Edmondson S, Devenish RJ, Ralph SJ. Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma. J Biol Chem 1997, 272(45):28779-28785. 10.1074/jbc.272.45.28779, 9353349.
    • (1997) J Biol Chem , vol.272 , Issue.45 , pp. 28779-28785
    • Wong, L.H.1    Krauer, K.G.2    Hatzinisiriou, I.3    Estcourt, M.J.4    Hersey, P.5    Tam, N.D.6    Edmondson, S.7    Devenish, R.J.8    Ralph, S.J.9
  • 36
    • 0036016562 scopus 로고    scopus 로고
    • Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (stat1)
    • 10.1089/10799900252982089, 12060499
    • Chawla-Sarkar M, Leaman DW, Jacobs BS, Tuthill RJ, Chatterjee-Kishore M, Stark GR, Borden EC. Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (stat1). J Interferon Cytokine Res 2002, 22(5):603-613. 10.1089/10799900252982089, 12060499.
    • (2002) J Interferon Cytokine Res , vol.22 , Issue.5 , pp. 603-613
    • Chawla-Sarkar, M.1    Leaman, D.W.2    Jacobs, B.S.3    Tuthill, R.J.4    Chatterjee-Kishore, M.5    Stark, G.R.6    Borden, E.C.7
  • 37
    • 0037502779 scopus 로고    scopus 로고
    • The JAK/STAT pathway is not sufficient to sustain the antiproliferative response in an interferon-resistant human melanoma cell line
    • 10.1097/00008390-200306000-00001, 12777975
    • Jackson DP, Watling D, Rogers NC, Banks RE, Kerr IM, Selby PJ, Patel PM. The JAK/STAT pathway is not sufficient to sustain the antiproliferative response in an interferon-resistant human melanoma cell line. Melanoma Res 2003, 13(3):219-229. 10.1097/00008390-200306000-00001, 12777975.
    • (2003) Melanoma Res , vol.13 , Issue.3 , pp. 219-229
    • Jackson, D.P.1    Watling, D.2    Rogers, N.C.3    Banks, R.E.4    Kerr, I.M.5    Selby, P.J.6    Patel, P.M.7
  • 39
    • 0037108433 scopus 로고    scopus 로고
    • Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells
    • 10.1182/blood-2002-01-0073, 12351404
    • Sakai I, Takeuchi K, Yamauchi H, Narumi H, Fujita S. Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells. Blood 2002, 100(8):2926-2931. 10.1182/blood-2002-01-0073, 12351404.
    • (2002) Blood , vol.100 , Issue.8 , pp. 2926-2931
    • Sakai, I.1    Takeuchi, K.2    Yamauchi, H.3    Narumi, H.4    Fujita, S.5
  • 40
    • 13544261739 scopus 로고    scopus 로고
    • Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha
    • 10.1038/sj.leu.2403610, 15618960
    • Brender C, Lovato P, Sommer VH, Woetmann A, Mathiesen AM, Geisler C, Wasik M, Odum N. Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha. Leukemia 2005, 19(2):209-213. 10.1038/sj.leu.2403610, 15618960.
    • (2005) Leukemia , vol.19 , Issue.2 , pp. 209-213
    • Brender, C.1    Lovato, P.2    Sommer, V.H.3    Woetmann, A.4    Mathiesen, A.M.5    Geisler, C.6    Wasik, M.7    Odum, N.8
  • 41
    • 34250347991 scopus 로고    scopus 로고
    • SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells
    • 10.1158/0008-5472.CAN-06-2575, 17510435
    • Zitzmann K, Brand S, De Toni EN, Baehs S, Goke B, Meinecke J, Spottl G, Meyer HH, Auernhammer CJ. SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells. Cancer Res 2007, 67(10):5025-5032. 10.1158/0008-5472.CAN-06-2575, 17510435.
    • (2007) Cancer Res , vol.67 , Issue.10 , pp. 5025-5032
    • Zitzmann, K.1    Brand, S.2    De Toni, E.N.3    Baehs, S.4    Goke, B.5    Meinecke, J.6    Spottl, G.7    Meyer, H.H.8    Auernhammer, C.J.9
  • 42
    • 49749151017 scopus 로고    scopus 로고
    • Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells
    • 10.1111/j.1349-7006.2008.00850.x, 18754879
    • Takahashi Y, Kaneda H, Takasuka N, Hattori K, Nishikawa M, Takakura Y. Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells. Cancer Sci 2008, 99(8):1650-1655. 10.1111/j.1349-7006.2008.00850.x, 18754879.
    • (2008) Cancer Sci , vol.99 , Issue.8 , pp. 1650-1655
    • Takahashi, Y.1    Kaneda, H.2    Takasuka, N.3    Hattori, K.4    Nishikawa, M.5    Takakura, Y.6
  • 43
    • 57149103930 scopus 로고    scopus 로고
    • Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis
    • 10.1158/0008-5472.CAN-08-1429, 19047140
    • Huang FJ, Steeg PS, Price JE, Chiu WT, Chou PC, Xie K, Sawaya R, Huang S. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res 2008, 68(23):9634-9642. 10.1158/0008-5472.CAN-08-1429, 19047140.
    • (2008) Cancer Res , vol.68 , Issue.23 , pp. 9634-9642
    • Huang, F.J.1    Steeg, P.S.2    Price, J.E.3    Chiu, W.T.4    Chou, P.C.5    Xie, K.6    Sawaya, R.7    Huang, S.8
  • 44
    • 11144254962 scopus 로고    scopus 로고
    • Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity
    • 10.1038/nbt1035, 15558048
    • Shen L, Evel-Kabler K, Strube R, Chen SY. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat Biotechnol 2004, 22(12):1546-1553. 10.1038/nbt1035, 15558048.
    • (2004) Nat Biotechnol , vol.22 , Issue.12 , pp. 1546-1553
    • Shen, L.1    Evel-Kabler, K.2    Strube, R.3    Chen, S.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.