Critical attributes of formulation and of elaboration process of PLGA-protein microparticles

International Journal of Pharmaceutics

Volumn 480, Issue 1-2, 2015, Pages 27-36

  Martin Sabroso C ^a   Fraguas Sanchez A I ^a   Aparicio Blanco, J ^a   Cano Abad, M F ^c,d,e   Torres Suarez A I ^a,b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d INSTITUTO TEÓFILO HERNANDO   (Spain)

^e AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

Author keywords

Albumin; Critical attributes; Microparticles; Poly(lactic co glycolic) acid; Protein microencapsulation; Quality by design

Indexed keywords

ALBUMIN; MACROGOL 400; ORGANIC SOLVENT; POLYGLACTIN; POLYMER; POLYVINYL ALCOHOL; SODIUM CHLORIDE; ALBUMINOID; DELAYED RELEASE FORMULATION; LACTIC ACID; MICROSPHERE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CLINICAL EVALUATION; CONCENTRATION RESPONSE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; EMULSION; EVAPORATION; HYDROPHOBICITY; IN VITRO STUDY; INTRACELLULAR TRANSPORT; MICROENCAPSULATION; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; SURFACE PROPERTY; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; DRUG RELEASE; MEDICINAL CHEMISTRY; PROCEDURES;

ALBUMINS; ANIMALS; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG LIBERATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTIC ACID; MICROSPHERES; MOLECULAR WEIGHT; PC12 CELLS; POLYGLYCOLIC ACID; RATS; SODIUM CHLORIDE; SOLVENTS;

EID: 84921770009     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.01.008     Document Type: Article

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