The nature of peptide interactions with acid end-group PLGAs and facile aqueous-based microencapsulation of therapeutic peptides

Journal of Controlled Release

Volumn 172, Issue 3, 2013, Pages 662-670

  Sophocleous, Andreas M ^a,c   Desai, Kashappa Goud H ^a,c   Mazzara, J Maxwell ^a   Tong, Ling ^b   Cheng, Ji Xin ^b   Olsen, Karl F ^a   Schwendeman, Steven P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PURDUE UNIVERSITY   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

Controlled release; Kinetics; Microencapsulation; Peptide; PLGA; Sorption

Indexed keywords

CONFOCAL RAMAN MICROSPECTROSCOPY; CONTROLLED RELEASE; ENCAPSULATION METHODS; LOW-MOLECULAR WEIGHT; PHYSIOLOGICAL TEMPERATURE; PLGA; STIMULATED RAMAN SCATTERINGS (SRS); TWO-PHASE EXTRACTION;

AMINO ACIDS; COPOLYMERS; ENZYME KINETICS; FUNCTIONAL POLYMERS; KINETICS; MICROENCAPSULATION; POLYMER FILMS; RATS; SORPTION;

PEPTIDES;

LEUPRORELIN; OCTREOTIDE; POLYGLACTIN; SODIUM AZIDE;

ABSORPTION; AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MALE; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTEIN INTERACTION; RAMAN SPECTROMETRY; RAT; SURFACE PROPERTY; TEMPERATURE;

CONTROLLED RELEASE; KINETICS; MICROENCAPSULATION; PEPTIDE; PLGA; SORPTION;

ADSORPTION; ANIMALS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; LACTIC ACID; LEUPROLIDE; MALE; OCTREOTIDE; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84887186370     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.08.295     Document Type: Article

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