Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside (Review)

Oncology Letters

Volumn 9, Issue 3, 2015, Pages 1039-1045

  Ye, Le Chi ^a   Zhu, De Xiang ^b   Qiu, Jun Jun ^c   Xu, Jianmin ^b   Wei, Ye ^b  

^a THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c OBSTETRICS AND GYNECOLOGY HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Colorectal cancer; Long non coding RNA

Indexed keywords

BETA CATENIN; COMPLEMENTARY RNA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LONG UNTRANSLATED RNA; PROTEIN P53; RETINOBLASTOMA PROTEIN; RNA H19; SOMATOMEDIN B;

APOPTOSIS; CANCER GROWTH; CANCER PREVENTION; COLORECTAL CANCER; DISTANT METASTASIS; DOWN REGULATION; EARLY DIAGNOSIS; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; LIVER METASTASIS; LUNG ADENOCARCINOMA; NEUROBLASTOMA; NONHUMAN; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PSEUDOGENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS; TUMOR SUPPRESSOR GENE; WNT SIGNALING PATHWAY;

EID: 84921746045     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.2846     Document Type: Review

References (71)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Esteller M: Non-coding RNAs in human disease. Nat Rev Genet 12: 861-874, 2011.
3. Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell 136: 629-641, 2009.
4. Kapranov P, Cheng J, Dike S, et al: RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316: 1484-1488, 2007.
5. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
6. Gutschner T and Diederichs S: The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol 9: 703-719, 2012.
7. Tsang WP, Ng EK, Ng SS, et al: Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis 31: 350-358, 2010.
8. Yoshimizu T, Miroglio A, Ripoche MA, et al: The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci USA 105: 12417-12422, 2008.
9. Moulton T, Crenshaw T, Hao Y, et al: Epigenetic lesions at the H19 locus in Wilms' tumour patients. Nat Genet 7: 440-447, 1994.
10. Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh CL and Feinberg AP: Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res 62: 6442-6446, 2002.
11. Fellig Y, Ariel I, Ohana P, et al: H19 expression in hepatic metastases from a range of human carcinomas. J Clin Pathol 58: 1064-1068, 2005.
12. Ohana P, Schachter P, Ayesh B, et al: Regulatory sequences of H19 and IGF2 genes in DNA-based therapy of colorectal rat liver metastases. J Gene Med 7: 366-374, 2005.
13. Sorin V, Ohana P, Mizrahi A, et al: Regional therapy with DTA-H19 vector suppresses growth of colon adenocarcinoma metastases in the rat liver. Int J Oncol 39: 1407-1412, 2011.
14. Gupta RA, Shah N, Wang KC, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464: 1071-1076, 2010.
15. Pádua Alves C, Fonseca AS, Muys BR, et al: Brief report: The lincRNA Hotair is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cell lines. Stem cells 31: 2827-2832, 2013.
16. Kogo R, Shimamura T, Mimori K, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res 71: 6320-6326, 2011.
17. Gutschner T, Hämmerle M, Eissmann M, et al: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 73: 1180-1189, 2013.
18. Chang JL, Li ZG, Wang XY and Yang MH: Detection of p53, MALAT1, ki-67 and β-catenin mRNA expression and its significance in molecular diagnosis of colorectal carcinoma. World Chinese J Digestol 16: 3849-3854, 2008.
19. Xu C, Yang M, Tian J, Wang X and Li Z: MALAT-1: a long non-coding RNA and its important 3' end functional motif in colorectal cancer metastasis. Int J Oncol 39: 169-175, 2011.
20. Ji Q, Liu X, Fu X, et al: Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One 8: e78700, 2013.
21. Panzitt K, Tschernatsch MM, Guelly C, et al: Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology 132: 330-342, 2007.
22. Matouk IJ, Abbasi I, Hochberg A, Galun E, Dweik H and Akkawi M: Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis. Eur J Gastroenterol Hepatol 21: 688-692, 2009.
23. Xie H, Ma H and Zhou D: Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma. Biomed Res Int 2013: 136106, 2013.
24. Miyoshi N, Wagatsuma H, Wakana S, et al: Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cells 5: 211-220, 2000.
25. Zhang X, Zhou Y, Mehta KR, et al: A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. J Clin Endocrinol Metab 88: 5119-5126, 2003.
26. Zhou Y, Zhang X and Klibanski A: MEG3 noncoding RNA: a tumor suppressor. J Mol Endocrinol 48:R45-R53, 2012.
27. Nissan A, Stojadinovic A, Mitrani-Rosenbaum S, et al: Colon cancer associated transcript-1: a novel RNA expressed in malignant and pre-malignant human tissues. Int J Cancer 130: 1598-1606, 2012.
28. Kam Y, Rubinstein A, Naik S, et al: Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons. Cancer Lett 352: 90-96, 2014.
29. Ling H, Spizzo R, Atlasi Y, et al: CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res 23: 1446-1461, 2013.
30. Graham LD, Pedersen SK, Brown GS, et al: Colorectal neoplasia differentially expressed (CRNDE), a novel gene with elevated expression in colorectal adenomas and adenocarcinomas. Genes Cancer 2: 829-840, 2011.
31. Ellis BC, Molloy PL and Graham LD: CRNDE: A long non-coding RNA Involved in CanceR, Neurobiology, and DEvelopment. Front Genet 3: 270, 2012.
32. Ellis BC, Graham LD and Molloy PL: CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta 1843: 372-386, 2014.
33. Liu Q, Huang J, Zhou N, et al: LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Res 41: 4976-4987, 2013.
34. Pibouin L, Villaudy J, Ferbus D, et al: Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas. Cancer Genet Cytogenet 133: 55-60, 2002.
35. Peng JC, Shen J and Ran ZH: Transcribed ultraconserved region in human cancers. RNA Biol 10: 1771-1777, 2013.
36. Scaruffi P: The transcribed-ultraconserved regions: a novel class of long noncoding RNAs involved in cancer susceptibility. ScientificWorldJournal 11: 340-352, 2011.
37. Calin GA, Liu CG, Ferracin M, et al: Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12: 215-229, 2007.
38. Sana J, Hankeova S, Svoboda M, Kiss I, Vyzula R and Slaby O: Expression levels of transcribed ultraconserved regions uc.73 and uc.388 are altered in colorectal cancer. Oncology 82: 114-118, 2012.
39. Wojcik SE, Rossi S, Shimizu M, et al: Non-coding RNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer. Carcinogenesis 31: 208-215, 2010.
40. Ng SY, Gunning P, Eddy R, et al: Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes. Mol Cell Biol 5: 2720-2732, 1985.
41. Poliseno L: Pseudogenes: newly discovered players in human cancer. Sci Signal 5: re5, 2012.
42. Wezel F, Pearson J, Kirkwood LA and Southgate J: Differential expression of Oct4 variants and pseudogenes in normal urothelium and urothelial cancer. Am J Pathol 183: 1128-1136, 2013.
43. Kastler S, Honold L, Luedeke M, et al: POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma. Prostate 70: 666-674, 2010.
44. Panagopoulos I, Möller E, Collin A and Mertens F: The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. Oncol Rep 20: 1029-1033, 2008.
45. Ali A, Saluja SS, Hajela K, Mishra PK and Rizvi MA: Mutational and expressional analyses of PTEN gene in colorectal cancer from Northern India. Mol Carcinog 53 Suppl 1: E45-E52, 2014.
46. Johnsson P, Ackley A, Vidarsdottir L, et al: A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat Struct Mol Biol 20: 440-446, 2013.
47. Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ and Pandolfi PP: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465: 1033-1038, 2010.
48. Lazar V and Garcia JG: A single human myosin light chain kinase gene (MLCK; MYLK). Genomics 57: 256-267, 1999.
49. Han YJ, Ma SF, Yourek G, Park YD and Garcia JG: A transcribed pseudogene of MYLK promotes cell proliferation. FASEB J 25: 2305-2312, 2011.
50. Rack KA, Delabesse E, Radford-Weiss I, et al: Simultaneous detection of MYC, BVR1, and PVT1 translocations in lymphoid malignancies by fluorescence in situ hybridization. Genes Chromosomes Cancer 23: 220-226, 1998.
51. Guan Y, Kuo WL, Stilwell JL, et al: Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res 13: 5745-5755, 2007.
52. Takahashi Y, Sawada G, Kurashige J, et al: Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. Br J Cancer 110: 164-171, 2014.
53. Barsotti AM, Beckerman R, Laptenko O, Huppi K, Caplen NJ and Prives C: p53-Dependent induction of PVT1 and miR-1204. J Biol Chem 287: 2509-2519, 2012.
54. Nakagawa H, Chadwick RB, Peltomaki P, Plass C, Nakamura Y and de La Chapelle A: Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci USA 98: 591-596, 2001.
55. Murakami K, Oshimura M and Kugoh H: Suggestive evidence for chromosomal localization of non-coding RNA from imprinted LIT1. J Hum Genet 52: 926-933, 2007.
56. Mitsuya K, Meguro M, Lee MP, et al: LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids. Hum Mol Genet 8: 1209-1217, 1999.
57. Nakano S, Murakami K, Meguro M, et al: Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers. Cancer Sci 97: 1147-1154, 2006.
58. Zhai H, Fesler A, Schee K, Fodstad O, Flatmark K and Ju J: Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer. Clin Colorectal Cancer 12: 261-266, 2013.
59. Wang G, Li Z, Zhao Q, et al: LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway. Oncol Rep 31: 1839-1845, 2014.
60. Yang F, Zhang H, Mei Y and Wu M: Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell 53: 88-100, 2014.
61. Yu M, Ohira M, Li Y, et al: High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma. Int J Oncol 34: 931-938, 2009.
62. Qi P, Xu MD, Ni SJ, et al: Down-regulation of ncRAN, a long non-coding RNA, contributes to colorectal cancer cell migration and invasion and predicts poor overall survival for colorectal cancer patients. Mol Carcinog, 2014.
63. Yang L, Lin C, Jin C, et al: lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature 500: 598-602, 2013.
64. Ge X, Chen Y, Liao X, et al: Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer. Med Oncol 30: 588, 2013.
65. Meyer LR, Zweig AS, Hinrichs AS, et al: The UCSC Genome Browser database: extensions and updates 2013. Nucleic Acids Res 41: D64-D69, 2013.
66. Chung S, Nakagawa H, Uemura M, et al: Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Sci 102: 245-252, 2011.
67. Li L, Sun R, Liang Y, et al: Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer. J Exp Clin Cancer Res 32: 104, 2013.
68. Yang F, Huo XS, Yuan SX, et al: Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell 49: 1083-1096, 2013.
69. Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146: 353-358, 2011.
70. Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature 505: 344-352, 2014.
71. Wang F, Li X, Xie X, Zhao L and Chen W: UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett 582: 1919-1927, 2008.