LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway

Oncology Reports

Volumn 31, Issue 4, 2014, Pages 1839-1845

  Wang, Guangyu ^a   Li, Zhiwei ^a   Zhao, Qi ^a   Zhu, Yuanyuan ^a   Zhao, Ci ^a   Li, Xin ^a   Ma, Zhigang ^a   Li, Xiaobo ^a   Zhang, Yanqiao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Cell apoptosis; Colorectal cancer; LincRNA p21; Radiosensitivity; Wnt catenin signaling pathway

Indexed keywords

BETA CATENIN; LONG UNTRANSLATED RNA; PROTEIN NOXA; PROTEIN P21; WNT PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR BIOLOGY; NOXA GENE; PRIORITY JOURNAL; RADIOSENSITIVITY; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HUMANS; RADIATION TOLERANCE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, LONG NONCODING; WNT SIGNALING PATHWAY;

EID: 84908141845     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3047     Document Type: Article

References (49)

1. Guttman M, Amit I, Garber M, et al: Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458: 223-227, 2009.
2. Katayama S, Tomaru Y, Kasukawa T, et al: Antisense transcription in the mammalian transcriptome. Science 309: 1564-1566, 2005.
3. Amaral PP, Clark MB, Gascoigne DK, Dinger ME and Mattick JS: lncRNAdb: a reference database for long noncoding RNAs. Nucleic Acids Res 39: D146-D151, 2011.
4. Goodrich JA and Kugel JF: Non-coding-RNA regulators of RNA polymerase II transcription. Nat Rev Mol Cell Biol 7: 612-616, 2006.
5. Chen X, Xu H, Yuan P, et al: Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133: 1106-1117, 2008.
6. Beltran M, Puig I, Peña C, et al: A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev 22: 756-769, 2008.
7. Centonze D, Rossi S, Napoli I, et al: The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum. J Neurosci 27: 8885-8892, 2007.
8. Braidotti G, Baubec T, Pauler F, et al: The Air noncoding RNA: an imprinted cis-silencing transcript. Cold Spring Harb Symp Quant Biol 69: 55-66, 2004.
9. Fu X, Ravindranath L, Tran N, Petrovics G and Srivastava S: Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. DNA Cell Biol 25: 135-141, 2006.
10. Lin R, Maeda S, Liu C, Karin M and Edgington TS: A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene 26: 851-858, 2007.
11. Calin GA, Liu CG, Ferracin M, et al: Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12: 215-229, 2007.
12. Braconi C, Valeri N, Kogure T, et al: Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. Proc Natl Acad Sci USA 108: 786-791, 2011.
13. Gibb EA, Brown CJ and Lam WL: The functional role of long non-coding RNA in human carcinomas. Molecular Cancer 10: 38, 2011.
14. Qi P and Du X: The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine. Mod Pathol 26: 155-165, 2013.
15. Weakley SM, Wang H, Yao Q and Chen C: Expression and function of a large non-coding RNA gene XIST in human cancer. World J Surg 35: 1751-1756, 2011.
16. Wang J, Liu X, Wu H, et al: CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res 38: 5366-5383, 2010.
17. Yuan S-X, Yang F, Yang Y, et al: Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy. Hepatology 56: 2231-2241, 2012.
18. Yang F, Xue X, Bi J, et al: Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol 139: 437-445, 2013.
19. Wu W, Bhagat TD, Yang X, et al: Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology 144: 956-966, 2013.
20. Tahira AC, Kubrusly MS, Faria MF, et al: Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer. Mol Cancer 10: 141, 2011.
21. Merchant JL: Inflammation, atrophy, gastric cancer: connecting the molecular dots. Gastroenterology 129: 1079-1082, 2005.
22. Huarte M, Guttman M, Feldser D, et al: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142: 409-419, 2010.
23. Zhai H, Fesler A, Schee K, Fodstad Ø, Flatmark K and Ju J: Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer. Clin Colorectal Cancer 12: 261-266, 2013.
24. Yoon JH, Abdelmohsen K, Srikantan S, et al: LincRNA-p21 suppresses target mRNA translation. Mol Cell 47: 648-655, 2012.
25. Samuels Y and Velculescu VE: Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 3: 1221-1224, 2004.
26. Wu K, Yang Q, Mu Y, Zhou L, Liu Y, Zhou Q and He B: Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. Int J Oncol 41: 292-298, 2012.
27. Dihlmann S, Klein S and Doeberitz Mv Mv: Reduction of β-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated β-catenin. Mol Cancer Ther 2: 509-516, 2003.
28. Boon EM, Keller JJ, Wormhoudt TA, et al: Sulindac targets nuclear β-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. Br J Cancer 90: 224-229, 2004.
29. Ji BC, Hsu WH, Yang JS, et al: Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem 57: 7596-7604, 2009.
30. Xi Y, Nakajima G, Gavin E, et al: Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA 13: 1668-1674, 2007.
31. Wang K, Zhang R, He F, et al: Electroacupuncture frequency-related transcriptional response in rat arcuate nucleus revealed region-distinctive changes in response to low- and high-frequency electroacupuncture. J Neurosci Res 90: 1464-1473, 2012.
32. Kalin TV, Wang IC, Ackerson TJ, et al: Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice. Cancer Res 66: 1712-1720, 2006.
33. Kim IM, Ackerson T, Ramakrishna S, et al: The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res 66: 2153-2161, 2006.
34. Glimelius B and Oliveira J; ESMO Guidelines Working Group Rectal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 20 (Suppl 4): S54-S56, 2009.
35. Sauer R, Becker H, Hohenberger W, et al: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351: 1731-1740, 2004.
36. Koukourakis MI, Giatromanolaki A, Sheldon H, et al: Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab. Clin Cancer Res 15: 7069-7076, 2009.
37. Kendziorra E, Ahlborn K, Spitzner M, et al: Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. Carcinogenesis 32: 1824-1831, 2011.
38. Özgür E, Mert U, Isin M, Okutan M, Dalay N and Gezer U: Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells. Clin Exp Med 13: 119-126, 2013.
39. Jemal A, Center MM, Ward E and Thun MJ: Cancer occurrence. Methods Mol Biol 471: 3-29, 2009.
40. Bordonaro M: Crosstalk between Wnt signaling and RNA processing in colorectal cancer. J Cancer 4: 96-103, 2013.
41. Li X, Pu J, Jiang S, et al: Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with β-catenin/TCF4 interaction in colorectal cancer cells. PLoS One 8: e68525, 2013.
42. Waaler J, Machon O, von Kries JP, et al: Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res 71: 197-205, 2011.
43. Bright-Thomas RM and Hargest R: APC, β-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer. Eur J Surg Oncol 29: 107-117, 2003.
44. He TC, Sparks AB, Rago C, et al: Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512, 1998.
45. Khor TO, Gul YA, Ithnin H and Seow HF: A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma. Int J Colorectal Dis 21: 291-300, 2006.
46. Cunningham D, Atkin W, Lenz HJ, et al: Colorectal cancer. Lancet 375: 1030-1047, 2010.
47. Raats DA, de Bruijn MT, Steller EJ, Emmink BL, Borel-Rinkes IH and Kranenburg O: Synergistic killing of colorectal cancer cells by oxaliplatin and ABT-737. Cell Oncol (Dordr) 34: 307-313, 2011.
48. Shibue T, Takeda K, Oda E, et al: Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17: 2233-2238, 2003.
49. Miyoshi-Imamura T, Kakinuma S, Kaminishi M, et al: Unique characteristics of radiation-induced apoptosis in the postnatally developing small intestine and colon of mice. Radiat Res 173: 310-318, 2010.