p53-dependent induction of PVT1 and miR-1204

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2509-2519

  Barsotti, Anthony M ^a   Beckerman, Rachel ^a   Laptenko, Oleg ^a   Huppi, Konrad ^b   Caplen, Natasha J ^b   Prives, Carol ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATIN IMMUNOPRECIPITATION; DOWNSTREAM TARGET; ECTOPIC EXPRESSIONS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; LUCIFERASE ASSAYS; MICRORNAS; NON-CODING RNAS; PROTEIN-CODING GENES; RESPONSE ELEMENTS; TARGET GENES; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

ASSAYS; CELL DEATH; ELECTROPHORETIC MOBILITY; GENES; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CODES (SYMBOLS);

LUCIFERASE; MICRORNA; MICRORNA 1204; MICRORNA 1205; MICRORNA 1206; MICRORNA 1207 3P; MICRORNA 1207 5P; MICRORNA 1208; PROTEIN P53; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ARTICLE; CELL DEATH; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 8Q; CONTROLLED STUDY; ENZYME ASSAY; GEL MOBILITY SHIFT ASSAY; GENE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE LOCATION; GENE LOCUS; GENETIC ANALYSIS; GENOME SIZE; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN RNA BINDING; PVT1 GENE; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CELL DEATH; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 8; GENETIC LOCI; HUMANS; MICRORNAS; PROTEINS; RESPONSE ELEMENTS; RNA PROCESSING, POST-TRANSCRIPTIONAL; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84856068652     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.322875     Document Type: Article

References (55)

1. Soussi, T. (2007) p53 alterations in human cancer. More questions than answers. Oncogene 26, 2145-2156
2. Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S. V., Hainaut, P., and Olivier, M. (2007) Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype. Lessons from recent developments in the IARC TP53 database. Hum. Mutat. 28, 622-629 (Pubitemid 46744292)
3. Lozano, G. (2010) Mouse models of p53 functions. Cold Spring Harb. Perspect. Biol. 2, a001115
4. Vousden, K. H., and Prives, C. (2009) Blinded by the Light. The Growing Complexity of p53. Cell 137, 413-431
5. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816 (Pubitemid 23346377)
6. el-Deiry, W. S., Harper, J. W., O'Connor, P. M., Velculescu, V. E., Canman, C. E., Jackman, J., Pietenpol, J. A., Burrell, M., Hill, D. E., and Wang, Y. (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54, 1169-1174 (Pubitemid 24108052)
7. Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., and Hannon, G. J. (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552-557
8. Yu, J., and Zhang, L. (2005) The transcriptional targets of p53 in apoptosis control. Biochem. Biophys. Res. Commun. 331, 851-858 (Pubitemid 40615516)
9. Chang, T. C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., Arking, D. E., Beer, M. A., Maitra, A., and Mendell, J. T. (2007) Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol. Cell 26, 745-752 (Pubitemid 46856245)
10. He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., Jackson, A. L., Linsley, P. S., Chen, C., Lowe, S. W., Cleary, M. A., and Hannon, G. J. (2007) A microRNA component of the p53 tumour suppressor network. Nature 447, 1130-1134 (Pubitemid 47014436)
11. Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N., Bentwich, Z., and Oren, M. (2007) Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol. Cell 26, 731-743 (Pubitemid 46856247)
12. Tazawa, H., Tsuchiya, N., Izumiya, M., and Nakagama, H. (2007) Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc. Natl. Acad. Sci. U.S.A. 104, 15472-15477 (Pubitemid 47502941)
13. Hermeking, H. (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ. 17, 193-199
14. Hermeking, H. (2007) p53 enters the microRNA world. Cancer Cell 12, 414-418
15. Yamakuchi, M., Ferlito, M., and Lowenstein, C. J. (2008) miR-34a repression of SIRT1 regulates apoptosis. Proc. Natl. Acad. Sci. U.S.A. 105, 13421-13426
16. Georges, S. A., Biery, M. C., Kim, S. Y., Schelter, J. M., Guo, J., Chang, A. N., Jackson, A. L., Carleton, M. O., Linsley, P. S., Cleary, M. A., and Chau, B. N. (2008) Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215. Cancer Res. 68, 10105-10112
17. Sachdeva, M., Zhu, S., Wu, F., Wu, H., Walia, V., Kumar, S., Elble, R., Watabe, K., and Mo, Y. Y. (2009) p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc. Natl. Acad. Sci. U.S.A. 106, 3207-3212
18. Song, B., Wang, Y., Kudo, K., Gavin, E. J., Xi, Y., and Ju, J. (2008) miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. Clin. Cancer Res. 14, 8080-8086
19. Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J. A., and Kosik, K. S. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137, 647-658
20. Yamakuchi, M., Lotterman, C. D., Bao, C., Hruban, R. H., Karim, B., Mendell, J. T., Huso, D., and Lowenstein, C. J. (2010) P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 107, 6334-6339
21. Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M. J., Kenzelmann-Broz, D., Khalil, A. M., Zuk, O., Amit, I., Rabani, M., Attardi, L. D., Regev, A., Lander, E. S., Jacks, T., and Rinn, J. L. (2010) A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142, 409-419
22. Barsotti, A. M., and Prives, C. (2010) Noncoding RNAs. The missing "linc"in p53-mediated repression. Cell 142, 358-360
23. Beck-Engeser, G. B., Lum, A. M., Huppi, K., Caplen, N. J., Wang, B. B., and Wabl, M. (2008) Pvt1-encoded microRNAs in oncogenesis. Retrovirology 5, 4
24. Huppi, K., Volfovsky, N., Runfola, T., Jones, T. L., Mackiewicz, M., Martin, S. E., Mushinski, J. F., Stephens, R., and Caplen, N. J. (2008) The identification of microRNAs in a genomically unstable region of human chromosome 8q24. Mol. Cancer Res. 6, 212-221 (Pubitemid 351342409)
25. Haverty, P. M., Hon, L. S., Kaminker, J. S., Chant, J., and Zhang, Z. (2009) High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors. BMC Med. Genomics 2, 21
26. Sircoulomb, F., Bekhouche, I., Finetti, P., Adélaïde, J., Ben Hamida, A., Bonansea, J., Raynaud, S., Innocenti, C., Charafe-Jauffret, E., Tarpin, C., Ben Ayed, F., Viens, P., Jacquemier, J., Bertucci, F., Birnbaum, D., and Chaffanet, M. (2010) Genome profiling of ERBB2-amplified breast cancers. BMC Cancer 10, 539
27. Schiffman, J. D., Hodgson, J. G., VandenBerg, S. R., Flaherty, P., Polley, M. Y., Yu, M., Fisher, P. G., Rowitch, D. H., Ford, J. M., Berger, M. S., Ji, H., Gutmann, D. H., and James, C. D. (2010) Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res. 70, 512-519
28. Kamath, A., Tara, H., Xiang, B., Bajaj, R., He, W., and Li, P. (2008) Double-minute MYC amplification and deletion of MTAP, CDKN2A, CDKN2B, and ELAVL2 in an acute myeloid leukemia characterized by oligonucleotide-array comparative genomic hybridization. Cancer Genet. Cytogenet. 183, 117-120 (Pubitemid 351707712)
29. Enciso-Mora, V., Broderick, P., Ma, Y., Jarrett, R. F., Hjalgrim, H., Hemminki, K., van den Berg, A., Olver, B., Lloyd, A., Dobbins, S. E., Lightfoot, T., van Leeuwen, F. E., Försti, A., Diepstra, A., Broeks, A., Vijayakrishnan, J., Shield, L., Lake, A., Montgomery, D., Roman, E., Engert, A., von Strandmann, E. P., Reiners, K. S., Nolte, I. M., Smedby, K. E., Adami, H. O., Russell, N. S., Glimelius, B., Hamilton-Dutoit, S., de Bruin, M., Ryder, L. P., Molin, D., Sorensen, K. M., Chang, E. T., Taylor, M., Cooke, R., Hofstra, R., Westers, H., van Wezel, T., van Eijk, R., Ashworth, A., Rostgaard, K., Melbye, M., Swerdlow, A. J., and Houlston, R. S. (2010) A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nat. Genet. 42, 1126-1130
30. Guan, Y., Kuo, W. L., Stilwell, J. L., Takano, H., Lapuk, A. V., Fridlyand, J., Mao, J. H., Yu, M., Miller, M. A., Santos, J. L., Kalloger, S. E., Carlson, J. W., Ginzinger, D. G., Celniker, S. E., Mills, G. B., Huntsman, D. G., and Gray, J. W. (2007) Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin. Cancer Res. 13, 5745-5755 (Pubitemid 47583899)
31. Carramusa, L., Contino, F., Ferro, A., Minafra, L., Perconti, G., Giallongo, A., and Feo, S. (2007) The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells. J. Cell Physiol. 213, 511-518 (Pubitemid 47509734)
32. Palumbo, A. P., Boccadoro, M., Battaglio, S., Corradini, P., Tsichlis, P. N., Huebner, K., Pileri, A., and Croce, C. M. (1990) Human homologue of Moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3′ of the myc gene, is rearranged in multiple myelomas. Cancer Res. 50, 6478-6482 (Pubitemid 20348763)
33. Borg, A., Baldetorp, B., Fernö, M., Olsson, H., and Sigurdsson, H. (1992) c-myc amplification is an independent prognostic factor in postmenopausal breast cancer. Int. J. Cancer 51, 687-691
34. You, L., Chang, D., Du, H. Z., and Zhao, Y. P. (2011) Genome-wide screen identifies PVT1 as a regulator of Gemcitabine sensitivity in human pancreatic cancer cells. Biochem. Biophys. Res. Commun. 407, 1-6
35. Marasa, B. S., Srikantan, S., Martindale, J. L., Kim, M. M., Lee, E. K., Gorospe, M., and Abdelmohsen, K. (2010) MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging 2, 333-343
36. Beckerman, R., Donner, A. J., Mattia, M., Peart, M. J., Manley, J. L., Espinosa, J. M., and Prives, C. (2009) A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev. 23, 1364-1377
37. Laptenko, O., Beckerman, R., Freulich, E., and Prives, C. (2011) p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation. Proc. Natl. Acad. Sci. U.S.A. 108, 10385-10390
38. Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., and Vogelstein, B. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282, 1497-1501 (Pubitemid 28538613)
39. Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., Fotouhi, N., and Liu, E. A. (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (Pubitemid 38174664)
40. Hoh, J., Jin, S., Parrado, T., Edington, J., Levine, A. J., and Ott, J. (2002) The p53MH algorithm and its application in detecting p53-responsive genes. Proc. Natl. Acad. Sci. U.S.A. 99, 8467-8472 (Pubitemid 34693586)
41. Wei, C. L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., Liu, J., Zhao, X. D., Chew, J. L., Lee, Y. L., Kuznetsov, V. A., Sung, W. K., Miller, L. D., Lim, B., Liu, E. T., Yu, Q., Ng, H. H., and Ruan, Y. (2006) A global map of p53 transcription-factor binding sites in the human genome. Cell 124, 207-219 (Pubitemid 43069320)
42. Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., and Miyazono, K. (2009) Modulation of microRNA processing by p53. Nature 460, 529-533
43. Shaulsky, G., Goldfinger, N., Peled, A., and Rotter, V. (1991) Involvement of wild-type p53 in pre-B-cell differentiation in vitro. Proc. Natl. Acad. Sci. U.S.A. 88, 8982-8986 (Pubitemid 21915554)
44. MacPherson, D., Kim, J., Kim, T., Rhee, B. K., Van Oostrom, C. T., DiTullio, R. A., Venere, M., Halazonetis, T. D., Bronson, R., De Vries, A., Fleming, M., and Jacks, T. (2004) Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J. 23, 3689-3699 (Pubitemid 39336290)
45. Aloni-Grinstein, R., Schwartz, D., and Rotter, V. (1995) Accumulation of wild-type p53 protein upon γ-irradiation induces a G2 arrest-dependent immunoglobulin κ light chain gene expression. EMBO J. 14, 1392-1401
46. Sheikh, M. S., and Fornace, A. J., Jr. (2000) Death and decoy receptors and p53-mediated apoptosis. Leukemia 14, 1509-1513 (Pubitemid 30601358)
47. Wu, G. S., Burns, T. F., McDonald, E. R., 3rd, Jiang, W., Meng, R., Krantz, I. D., Kao, G., Gan, D. D., Zhou, J. Y., Muschel, R., Hamilton, S. R., Spinner, N. B., Markowitz, S., Wu, G., and el-Deiry, W. S. (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat. Genet. 17, 141-143
48. Wu, W. S., Heinrichs, S., Xu, D., Garrison, S. P., Zambetti, G. P., Adams, J. M., and Look, A. T. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123, 641-653 (Pubitemid 41613746)
49. Zilfou, J. T., Spector, M. S., and Lowe, S. W. (2005) Slugging it out. Fine tuning the p53-PUMA death connection. Cell 123, 545-548 (Pubitemid 41608457)
50. Jänicke, R. U., Sohn, D., Essmann, F., and Schulze-Osthoff, K. (2007) The multiple battles fought by anti-apoptotic p21. Cell Cycle 6, 407-413 (Pubitemid 46393442)
51. Zhao, J., Ohsumi, T. K., Kung, J. T., Ogawa, Y., Grau, D. J., Sarma, K., Song, J. J., Kingston, R. E., Borowsky, M., and Lee, J. T. (2010) Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol. Cell 40, 939-953
52. Gieni, R. S., and Hendzel, M. J. (2009) Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer. Biochem. Cell Biol. 87, 711-746
53. Lazo, P. A., Lee, J. S., and Tsichlis, P. N. (1990) Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas. Proc. Natl. Acad. Sci. U.S.A. 87, 170-173
54. Marcu, K. B., Bossone, S. A., and Patel, A. J. (1992) myc function and regulation. Annu. Rev. Biochem. 61, 809-860
55. Ho, J. S., Ma, W., Mao, D. Y., and Benchimol, S. (2005) p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol. Cell Biol. 25, 7423-7431 (Pubitemid 41170106)