PH-controlled gas-generating mineralized nanoparticles: A theranostic agent for ultrasound imaging and therapy of cancers

ACS Nano

Volumn 9, Issue 1, 2015, Pages 134-145

  Min, Kyung Hyun ^a,b   Min, Hyun Su ^a   Lee, Hong Jae ^c   Park, Dong Jin ^c   Yhee, Ji Young ^a   Kim, Kwangmeyung ^a   Kwon, Ick Chan ^a   Jeong, Seo Young ^c   Silvestre, Oscar F ^b   Chen, Xiaoyuan ^b   Hwang, Yu Shik ^c   Kim, Eun Cheol ^c   Lee, Sang Cheon ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^c Kyung Hee University   (South Korea)

Author keywords

carbon dioxide; drug delivery; mineralization; nanobubble; theranostics; ultrasound

Indexed keywords

BLOCK COPOLYMERS; CALCIUM CARBONATE; CARBON; DISEASES; DRUG DELIVERY; MINERALOGY; NANOPARTICLES; TUMORS; ULTRASONIC IMAGING; ULTRASONICS;

HYBRID NANOPARTICLE; MINERALIZATION; NANO-BUBBLE; THERANOSTIC AGENTS; THERANOSTICS; THERAPEUTIC ACTIVITY; THERAPEUTIC FUNCTIONS; ULTRASOUND IMAGING;

CARBON DIOXIDE;

ANTINEOPLASTIC AGENT; CALCIUM CARBONATE; CARBON DIOXIDE; DOXORUBICIN; DRUG CARRIER; NANOPARTICLE;

ANIMAL; CARCINOMA, SQUAMOUS CELL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG RELEASE; ECHOGRAPHY; HUMAN; INTRACELLULAR SPACE; MALE; METABOLISM; MOUSE; PATHOLOGY; PH; PROCEDURES; THERANOSTIC NANOMEDICINE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CALCIUM CARBONATE; CARBON DIOXIDE; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DOXORUBICIN; DRUG CARRIERS; DRUG LIBERATION; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NANOPARTICLES; THERANOSTIC NANOMEDICINE;

EID: 84921718557     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn506210a     Document Type: Article

References (43)

1. Lindner, J. R. Microbubbles in Medical Imaging: Current Applications and Future Directions Nat. Rev. Drug Discovery 2004, 3, 527-533
2. Stewart, V. R.; Sidhu, P. S. New Directions in Ultrasound: Microbubble Contrast Br. J. Radiol. 2006, 79, 188-194
3. Willmann, J. K.; van Bruggen, N.; Dinkelborg, L. M.; Gambhir, S. S. Molecular Imaging in Drug Development Nat. Rev. Drug Discovery 2008, 7, 591-607
4. Qin, S. P.; Caskey, C. F.; Ferrara, K. W. Ultrasound Contrast Microbubbles in Imaging and Therapy: Physical Principles and Engineering Phys. Med. Biol. 2009, 54, R27-R57
5. Ferrara, K.; Pollard, R.; Borden, M. Ultrasound Microbubble Contrast Agents: Fundamentals and Application to Gene and Drug Delivery Annu. Rev. Biomed. Eng. 2007, 9, 415-447
6. Schutt, E. G.; Klein, D. H.; Mattrey, R. M.; Riess, J. G. Injectable Microbubbles as Contrast Agents for Diagnostic Ultrasound Imaging: The Key Role of Perfluorochemicals Angew. Chem., Int. Ed. 2003, 42, 3218-3235
7. Kiessling, F.; Gaetjens, J.; Palmowski, M. Application of Molecular Ultrasound for Imaging Integrin Expression Theranostics 2011, 1, 127-134
8. Hernot, S.; Klibanov, A. L. Microbubbles in Ultrasound-Triggered Drug and Gene Delivery Adv. Drug Delivery Rev. 2008, 60, 1153-1166
9. Sanna, V.; Pintus, G.; Bandiera, P.; Anedda, R.; Punzoni, S.; Sanna, B.; Migaleddu, V.; Uzzau, S.; Sechi, M. Development of Polymeric Microbubbles Targeted to Prostate-Specific Membrane Antigen as Prototype of Novel Ultrasound Contrast Agents Mol. Pharmaceutics 2011, 8, 748-757
10. Willmann, J. K.; Kimura, R. H.; Deshpande, N.; Lutz, A. M.; Cochran, J. R.; Gambhir, S. S. Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides J. Nucl. Med. 2010, 51, 433-440
11. Iagaru, A.; Gambhir, S. S. Imaging Tumor Angiogenesis: The Road to Clinical Utility Am. J. Roentgenol. 2013, 201, W183-W191
12. Wilson, S. R.; Burns, P. N. Microbubble-Enhanced US in Body Imaging: What Role? Radiology 2010, 257, 24-39
13. Willmann, J. K.; Paulmurugan, R.; Chen, K.; Gheysens, O.; Rodriguez-Porcel, M.; Lutz, A. M.; Chen, I. Y.; Chen, X.; Gambhir, S. S. US Imaging of Tumor Angiogenesis with Microbubbles Targeted to Vascular Endothelial Growth Factor Receptor Type 2 in Mice Radiology 2008, 246, 508-518
14. Kiessling, F.; Gaetjens, J.; Palmowski, M. Application of Molecular Ultrasound for Imaging Integrin Expression Theranostics 2011, 1, 127-134
15. Bloch, S. H.; Wan, M.; Dayton, P. A.; Ferrara, K. W. Optical Observation of Lipid- and Polymer-Shelled Ultrasound Microbubble Contrast Agents Appl. Phys. Lett. 2004, 84, 631-633
16. Min, H. S.; Kang, E.; Koo, H.; Lee, J.; Kim, K.; Park, R.-W.; Kim, I.-S.; Choi, Y.; Kwon, I. C.; Han, M. Gas-Generating Polymeric Microspheres for Long-Term and Continuous In Vivo Ultrasound Imaging Biomaterials 2012, 33, 936-944
17. Kang, E.; Min, H. S.; Lee, J.; Han, M. H.; Ahn, H. J.; Yoon, I. C.; Choi, K.; Kim, K.; Park, K.; Kwon, I. C. Nanobubbles from Gas-Generating Polymeric Nanoparticles: Ultrasound Imaging of Living Subjects Angew. Chem., Int. Ed. 2010, 49, 524-528
18. Janib, S. M.; Moses, A. S.; MacKay, J. A. Imaging and Drug Delivery Using Theranostic Nanoparticles Adv. Drug Delivery Rev. 2010, 62, 1052-1063
19. Tassa, C.; Shaw, S. Y.; Weissleder, R. Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy Acc. Chem. Res. 2011, 44, 842-852
20. Ambrogio, M. W.; Thomas, C. R.; Zhao, Y.-L.; Zink, J. I.; Stoddart, J. F. Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine Acc. Chem. Res. 2011, 44, 903-913
21. Melancon, M. P.; Zhou, M.; Li, C. Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles Acc. Chem. Res. 2011, 44, 947-956
22. Pan, D.; Caruthers, S. D.; Hu, G.; Senpan, A.; Scott, M. J.; Gaffney, P. J.; Wickline, S. A.; Lanza, G. M. Ligand-Directed Nanobialys as Theranostic Agent for Drug Delivery and Manganese-Based Magnetic Resonance Imaging of Vascular Targets J. Am. Chem. Soc. 2008, 130, 9186-9187
23. Taratula, O.; Schumann, C.; Naleway, M. A.; Pang, A. J.; Chon, K. J.; Taratula, O. A Multifunctional Theranostic Platform Based on Phthalocyanine-Loaded Dendrimer for Image-Guided Drug Delivery and Photodynamic Therapy Mol. Pharmaceutics 2013, 10, 3946-3958
24. Xiao, Y.; Hong, H.; Matson, V. Z.; Javadi, A.; Xu, W.; Yang, Y.; Zhang, Y.; Engle, J. W.; Nickles, R. J.; Cai, W. Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anticancer Drug Delivery and PET Imaging Theranostics 2012, 2, 757-768
25. Yoo, D.; Lee, J.-H.; Shin, T.-H.; Cheon, J. Theranostic Magnetic Nanoparticles Acc. Chem. Res. 2011, 44, 863-874
26. Kim, D.; Jeong, Y. Y.; Jon, S. A Drug-Loaded Aptamer-Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer ACS Nano 2010, 4, 3689-3696
27. Choi, K. Y.; Jeon, E. J.; Yoon, H. Y.; Lee, B. S.; Na, J. H.; Min, K. H.; Kim, S. Y.; Myung, S. J.; Lee, S.; Chen, X. Theranostic Nanoparticles Based on PEGylated Hyaluronic Acid for the Diagnosis, Therapy and Monitoring of Colon Cancer Biomaterials 2012, 33, 6186-6193
28. Gerweck, L. E.; Seetharaman, K. Cellular pH Gradient in Tumor versus Normal Tissue: Potential Exploitation for the Treatment of Cancer Cancer Res. 1996, 56, 1194-1198
29. Min, K. H.; Kim, J. H.; Bae, S. M.; Shin, H.; Kim, M. S.; Park, S.; Lee, H.; Park, R. W.; Kim, I. S.; Kim, K. Tumoral Acidic pH-Responsive MPEG-Poly(β-amino ester) Polymeric Micelles for Cancer Targeting Therapy J. Controlled Release 2010, 144, 259-266
30. Lee, H. J.; Kim, S. E.; Kwon, I. K.; Park, C.; Kim, C.; Yang, J.; Lee, S. C. Spatially Mineralized Self-Assembled Polymeric Nanocarriers with Enhanced Robustness and Controlled Drug-Releasing Property Chem. Commun. 2010, 46, 377-379
31. Min, K. H.; Lee, H. J.; Kim, K.; Kwon, I. C.; Jeong, S. Y.; Lee, S. C. The Tumor Accumulation and Therapeutic Efficacy of Doxorubicin Carried in Calcium Phosphate-Reinforced Polymer Nanoparticles Biomaterials 2012, 33, 5788-5797
32. Rim, H. P.; Min, K. H.; Lee, H. J.; Jeong, S. Y.; Lee, S. C. pH-Tunable Calcium Phosphate Covered Mesoporous Silica Nanocontainers for Intracellular Controlled Release of Guest Drugs Angew. Chem., Int. Ed. 2011, 50, 8853-8857
33. 2 Gas Forming Agents Int. J. Pharm. 2002, 239, 81-91
34. 3 in Aqueous Solution: Size Control of Spherical Vaterite Particles Langmuir 2002, 18, 3655-3658
35. Goss, S. L.; Lemons, K. A.; Kerstetter, J. E.; Bogner, R. H. Determination of Calcium Salt Solubility with Changes in pH and P(CO(2)), Simulating Varying Gastrointestinal Environments J. Pharm. Pharmacol. 2007, 59, 1485-1492
36. Wike-Hooley, J. L.; Haveman, J.; Reinhold, J. S. The Relevance of Tumour pH to the Treatment of Malignant Disease Radiother. Oncol. 1984, 2, 343-366
37. Nido, P. J. D.; Glynn, P.; Buenaventura, P.; Salama, G.; Koretsky, A. P. Fluorescence Measurement of Calcium Transients in Perfused Rabbit Heart Using Rhod 2 Am. J. Physiol. 1998, 274, 728-741
38. Fonteriz, R. I.; Fuente, S. D. I.; Moreno, A.; Lobaton, C. D.; Montero, M.; Alvarez, J. Monitoring Mitochondrial [Ca2+] Dynamics with Rhod-2, Ratiometric Pericam and Aequorin Cell Calcium 2010, 48, 61-69
39. Daly, W. H.; Poché, D. The Preparation of N -Carboxyanhydrides of α-Amino Acids Using Bis(trichloromethyl)carbonate Tetrahedron Lett. 1988, 29, 5859-5862
40. Lee, S. J.; Min, K. H.; Lee, H. J.; Koo, A. N.; Rim, H. P.; Jeon, B. J.; Jeong, S. Y.; Heo, J. S.; Lee, S. C. Ketal Cross-Linked Poly(ethylene glycol)-Poly(amino acid)s Copolymer Micelles for Efficient Intracellular Delivery of Doxorubicin Biomacromolecules 2011, 12, 1224-1233
41. Harada, A.; Kataoka, K. Novel Polyion Complex Micelles Entrapping Enzyme Molecules in the Core: Preparation of Narrowly-Distributed Micelles from Lysozyme and Poly(ethylene glycol)-Poly(aspartic acid) Block Copolymer in Aqueous Medium Macromolecules 1998, 31, 288-294
42. Decano, J. L.; Moran, A. M.; Ruiz-Opazo, N.; Herrera, V. L. Molecular Imaging of Vasa Vasorum Neovascularization via DEspR-Targeted Contrast-Enhanced Ultrasound Micro-imaging in Transgenic Atherosclerosis Rat Model Mol. Imaging Biol. 2011, 13, 1096-1106
43. Min, K. H.; Park, K.; Kim, Y.-S.; Bae, S. M.; Lee, S.; Jo, H. G.; Park, R.-W.; Kim, I.-S.; Jeong, S. Y.; Kim, K. Hydrophobically Modified Glycol Chitosan Nanoparticles-Encapsulated Camptothecin Enhance the Drug Stability and Tumor Targeting in Cancer Therapy J. Controlled Release 2008, 127, 208-218