Determination of calcium salt solubility with changes in pH and P Co2 simulating varying gastrointestinal environments

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 11, 2007, Pages 1485-1492

  Goss, Sandra L ^a   Lemons, Karen A ^a   Kerstetter, Jane E ^a   Bogner, Robin H ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CALCIUM CARBONATE; CALCIUM OXALATE; CALCIUM PHOSPHATE; CALCIUM SALT; CARBON DIOXIDE; CITRATE CALCIUM; GLYCEROPHOSPHATE;

ARTICLE; CALCIUM ABSORPTION; CARBON DIOXIDE TENSION; DRUG ABSORPTION; DRUG SOLUBILITY; EQUILIBRIUM CONSTANT; GASTROINTESTINAL TRACT; HUMAN; IN VIVO STUDY; INTESTINE ABSORPTION; PH MEASUREMENT; PRECIPITATION; SMALL INTESTINE;

CALCIUM CARBONATE; CALCIUM CITRATE; CALCIUM COMPOUNDS; CALCIUM OXALATE; CALCIUM PHOSPHATES; CARBON DIOXIDE; GASTROINTESTINAL TRACT; GLYCEROPHOSPHATES; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; PARTIAL PRESSURE; PRECIPITATION; SOLUBILITY;

EID: 35848961640     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.11.0004     Document Type: Article

References (28)

1. Amidon, G., Lennernas, H., Shah, V., Crison, J. (1995) A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12: 413-420
2. Assoumani, M. (1998) Physical-chemical properties of calcium sources. Agro. Food Ind. Hi-Tech. 9: 33-35
3. Bromley, L. (1973) Thermodynamic properties of strong electrolytes in aqueous solutions. AIChE J. 19: 313-320
4. Bronner, F. (2003) Mechanisms of intestinal calcium absorption. J. Cell. Biochem. 88: 387-393
5. Bronner, F., Pansu, D. (1999) Nutritional aspects of calcium absorption. J. Nutr. 129: 9-12
6. Butler, J. (1991) Carbon dioxide equilibria and their applications. Lewis Publishers, Chelsea, MI, USA
7. Cayon, E., Roquer, M. (1997) Solubility of calcium salts and their effect on osteoporosis. Methods Find. Exp. Clin. Pharmacol. 19: 501-504
8. Fallingborg, J. (1999) Intraluminal pH of the human gastrointestinal tract. Danish Med. Bull. 46: 183-196
9. Favus, M. (1996) Primer on the metabolic bone diseases and disorders of mineral metabolism. Lippincott Williams and Wilkins, Philadelphia, PA, USA
10. Giuliano, A., Wood, R. (1991) Vitamin D-regulated calcium transport in Caco-2 cells: unique in vitro model. Am. J. Physiol. 260: G207-G212
11. Harvey, J. A., Zobitz, M. M., Pak, C. Y. C. (1988) Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate. J. Bone Miner. Res. 3: 253-258
12. Heaney, R., Recker, R., Weaver, C. (1990a) Absorbability of calcium sources: the limited role of solubility. Calcif. Tissue Int. 46: 300-304
13. Heaney, R., Weaver, C., Fitzsimmons, M. (1990b) Influence of calcium load on absorption fraction. J. Bone Miner. Res. 5: 1135-1138
14. Heaney, R. P.. Dowell, M. S., Barger-Lux, M. J. (1999) Absorption of calcium salts as the carbonate and citrate salts, with some observations on method. Osteoporosis Int. 9: 19-23
15. Heaney, R. P., Dowell, M. S., Bierman, J., Hale, C. A., Bendich, A. (2001) Absorbability and cost effectiveness in calcium supplementation. J. Am. Coll. Nutr. 20: 239-246
16. Heller, H., Stewart, A., Haynes, S., Pak, C. (1999) Pharmacokinetics of calcium absorption from two commercial calcium supplements. J. Clin. Pharmacol. 39: 1151-1154
17. Hodgman, C. (2004) Handbook of chemistry and physics. CRC Press, Inc., Boca Raton, FL. USA
18. Johnson, L. (2001) Gastrointestinal physiology. Mosby Inc., St Louis. MO, USA
19. Lindahl, A., Ungell, A., Knutson, L., Lennernas, H. (1997) Characterization of fluids from the stomach and proximal jejunum in men and women. Pharm. Res. 14: 497-502
20. Linke, W. (1958) Solubility: inorganic and metal-organic compounds. American Chemical Society, Washington, DC, USA
21. McNamara, D. P., Whitney, K. M., Goss, S. L. (2003) Use of a physiologic bicarbonate buffer system for dissolution characterization of ionizable drugs. Pharm. Res. 20: 1641-1646
22. Nicar, M. J., Pak, C. Y. C. (1985) Calcium bioavailability from calcium carbonate and calcium citrate. J. Clin. Endocrinol. Metab. 61: 391-393
23. Recker, R. R. (1985) Calcium absorption and achlorhydria. N. Engl. J. Med. 313: 70-73
24. Roth-Bassell, H., Clydesdale, F. (1992) In vitro solubility characteristics of six calcium salts. J. Food Prot. 55: 1003-1005
25. Rune, S. (1972) Acid-base parameters of duodenal contents in man. Gastroenterology 62: 533-539
26. Sheikh, M. S., Santa Ana, C. A., Nicar, M. J., Schiller, L. R., Fordtran, J. S. (1987) Gastrointestinal absorption of calcium from milk and calcium salts. N. Engl. J. Med. 317: 532-536
27. Sheikh, M. S., Santa Ana, C. A., Nicar, M. J., Schiller, L. R., Fordtran, J. S. (1988) Calcium absorption: effect of meal and glucose polymer. Am. J. Clin. Nutr. 48: 312-315
28. Surendran, N., Nguyen, L., Giuliano, A., Blanchard, J. (1995) Enhancement of calcium transport in the Caco-2 cell monolayer model. J. Pharm. Res. 84: 410-414