Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer

Oncotarget

Volumn 6, Issue 2, 2015, Pages 1064-1078

  Zhao, Fengjin ^a   Lin, Tianxin ^a   He, Wang ^a   Han, Jinli ^a   Zhu, Dingjun ^a   Hu, Kaishun ^a   Li, Weicong ^a   Zheng, Zaosong ^a   Huang, Jian ^a   Xie, Wenlian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Apoptosis; Bladder cancer; LincRNA; Proliferation

Indexed keywords

APOPTOSIS ASSOCIATED TRANSCRIPT IN BLADDER; CASPASE 3; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; LONG UNTRANSLATED RNA; PROTEIN P18; RETINOBLASTOMA PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; AATBC LONG NONCODING RNA, HUMAN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER INHIBITION; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; MUSCLE INVASIVE BLADDER CANCER; NOD SCID MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; BLADDER TUMOR; CELL LINE; DRUG SCREENING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; NONOBESE DIABETIC MOUSE; PATHOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SCID MOUSE; TUMOR CELL LINE; TUMOR VOLUME; WESTERN BLOTTING;

AGED; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE, INBRED NOD; MICE, SCID; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, LONG NONCODING; TUMOR BURDEN; URINARY BLADDER NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84921712127     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2833     Document Type: Article

References (38)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.
2. Shariat SF, Lotan Y, Vickers A, Karakiewicz PI, Schmitz-Dräger BJ, Goebell PJ, Malats N. Statistical consideration for clinical biomarker research in bladder cancer. Urologic Oncology: Seminars and Original Investigations. 2010; 28(4):389-400.
3. Parker J, Spiess PE. Current and Emerging Bladder Cancer Urinary Biomarkers. The Scientific World JOURNAL. 2011; 11:1103-12.
4. Neureiter D. Epigenetics and pancreatic cancer: Pathophysiology and novel treatment aspects. World Journal of Gastroenterology. 2014; 20(24):7830-48.
5. Kang C. Epigenetics: An emerging player in gastric cancer. World Journal of Gastroenterology. 2014; 20(21):6433-47.
6. Vance KW, Ponting CP. Transcriptional regulatory functions of nuclear long noncoding RNAs. Trends in Genetics. 2014; 30(8):348-55.
7. Beckedorff Felipe C, Amaral Murilo S, Deocesano-Pereira C, Verjovski-Almeida S. Long non-coding RNAs and their implications in cancer epigenetics. Bioscience Reports. 2013; 33(4):667-75.
8. Maruyama R and Suzuki H. Long noncoding RNA involvement in cancer. BMB reports. 2012; 45(11):604-11.
9. Nam JW, Bartel DP. Long noncoding RNAs in C. elegans. Genome Research. 2012; 22(12):2529-40.
10. Pastori C, Wahlestedt C. Involvement of long noncoding RNAs in diseases affecting the central nervous system. RNA Biology. 2012; 9(6):860-70.
11. Enfield KSS, Pikor LA, Martinez VD, Lam WL. Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genetics Research International. 2012; 2012:1-16.
12. Hao Li, Beiqin Yu, Jianfang Li, Liping Su, Min Yan, Zhenggang Zhu, Bingya Liu. Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. Oncotarget. 2014; 5(8):2318-29.
13. Wang F, Li X, Xie X, Zhao L, Chen W. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett. 2008; 582(13):1919-27.
14. Luo M, Li Z, Wang W, Zeng Y, Liu Z, Qiu J. Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. Cancer Lett. 2013 Jun 10;333(2):213-21.
15. He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, Luo J, Yu H, Huang J, Lin T. linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2013; 1832(10):1528-37.
16. Davies C, Tournier C. Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies. Biochem Soc Trans. 2012; 40(1):85-9.
17. Namani A, Li Y, Wang XJ, Tang X. Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer. Biochim Biophys Acta. 2014; 1843(9):1875-85.
18. Luo Z, Dong X, Ke Q, Duan Q, Shen L. Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation. Oncol Rep. 2014; 32(5):2215-22.
19. De Ocesano-Pereira C, Amaral MS, Parreira KS, Ayupe AC, Jacysyn JF, Amarante-Mendes GP, Reis EM, Verjovski-Almeida S. Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis. Nucleic Acids Research. 2014; 42(13):8343-55.
20. Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2012; 32(13):1616-25.
21. Zhao H, Zhang X, Frazão JB, Condino-Neto A, Newburger PE. HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells. Journal of Cellular Biochemistry. 2013; 114(10):2375-83.
22. Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou Y, Cheunsuchon P, Louis DN, Klibanski A. Maternally Expressed Gene 3, an Imprinted Noncoding RNA Gene, is Associated with Meningioma Pathogenesis and Progression. Cancer Research. 2010; 70(6):2350-58.
23. Gomez D. Telomere structure and telomerase in health and disease (Review). International Journal of Oncology. 2012 ;41(5):1561-9.
24. Xu C, Zeng Q, Xu W, Jiao L, Chen Y, Zhang Z, Wu C, Jin T, Pan A, Wei R, Yang B, Sun Y. miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR. Molecular Cancer Therapeutics. 2012; 12(2):207-19.
25. Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, Leonard JP, Mason CE, Chen-Kiang S. Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kd inhibition through PIK3IP1. Cell Cycle. 2013; 12(12):1892-900.
26. Gogolin S, Ehemann V, Becker G, Brueckner LM, Dreidax D, Bannert S, Nolte I, Savelyeva L, Bell E, Westermann F. CDK4 inhibition restores G1-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage. Cell Cycle. 2013; 12(7):1091-104.
27. Matsuzaki Y, Sakai T. INK4 Family-A promising target for gene-regulating chemoprevention and molecular-targeting prevention of cancer. Environ Health Prev Med. 2005; 10(2):72-7.
28. White E. Life, death, and the pursuit of apoptosis. Genes & Development. 1996; 10(1):1-15.
29. M.V. Fiandaloand N. Kyprianou. Caspase control: protagonists of cancer cell apoptosis. Exp Oncol. 2012 ; 34(3): 165-75.
30. Hensley P, Mishra M, Kyprianou N. Targeting caspases in cancer therapeutics. Biological Chemistry. 2013; 394(7):831-43.
31. Huang C, Bruggeman LA, Hydo LM, Miller RT. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. Experimental Cell Research. 2012; 318(10):1075-85.
32. Tanaka T, Nakatani T, Kamitani T. Inhibition of NEDD8-conjugation pathway by novel molecules: Potential approaches to anticancer therapy. Molecular Oncology. 2012; 6(3):267-75.
33. Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene. 2008; 27(48):6245-51.
34. Huang CY, Kuo WW, Yeh YL, Ho TJ, Lin JY, Lin DY, Chu CH, Tsai FJ, Tsai CH, Huang CY. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell Death Differ. 2014 ;21(8):1262-74.
35. Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev. 2013; 27(20):2179-91.
36. Shelton LM, Park BK, Copple IM. Role of Nrf2 in protection against acute kidney injury. Kidney Int. 2013; 84(6):1090-5.
37. Hayden A, Douglas J, Sommerlad M, Andrews L, Gould K, Hussain S, Thomas GJ, Packham G, Crabb SJ. The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer. Urol Oncol. 2014; 32(6):806-14.
38. Duong HQ, Yi YW, Kang HJ, Hong YB, Tang W, Wang A, Seong YS, Bae I. Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine. Int J Oncol. 2014; 44(3):959-69.