Current and emerging bladder cancer urinary biomarkers

TheScientificWorldJournal

Volumn 11, Issue , 2011, Pages 1103-1112

  Parker, Justin ^a   Spiess, Philippe E ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Bladder cancer; BLCA 4; BTA stat; FISH; Hyaluronic acid; Immunocyt; Microsatellite analysis; NMP22; Telomerase; Urinary cytology

Indexed keywords

CYTOKERATIN 20; HYALURONIC ACID; MICROSATELLITE DNA; MONOCLONAL ANTIBODY; NUCLEAR MATRIX PROTEIN 22; SURVIVIN; TELOMERASE; TUMOR ANTIGEN; TUMOR MARKER; UROPLAKIN;

BLADDER CANCER; CANCER DIAGNOSIS; CANCER EPIDEMIOLOGY; CANCER RECURRENCE; CYSTOSCOPY; CYTOLOGY; DISEASE MARKER; FLUORESCENCE IN SITU HYBRIDIZATION; GENOMICS; HUMAN; IMMUNOCYTOCHEMISTRY; PROTEOMICS; REVIEW; SENSITIVITY AND SPECIFICITY; URINE;

ANTIGENS, CD15; ANTIGENS, NEOPLASM; HUMANS; HYALURONIC ACID; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROSATELLITE REPEATS; NUCLEAR PROTEINS; SENSITIVITY AND SPECIFICITY; TELOMERASE; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS; URINE;

EID: 79958081710     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2011.104     Document Type: Review

References (53)

1. Jemal, A., Siegel, R., Xu, J., and Ward, E. (2010) Cancer statistics, 2010. CA Cancer J. Clin. 60, 277-300.
2. Shelley, M.D., Mason, M.D., and Kynaston, H. (2010) Intravesical therapy for superficial bladder cancer: a systematic review of randomized trials and meta-analyses. Cancer Treat. Rev. 36, 195-205.
3. Villicana, P., Whiting, B., Goodison, S., and Rosser, C.J. (2009) Urine-based assays for the detection of bladder cancer. Biomark. Med. 3, 265.
4. Tritschler, S., Sommer, M.L., Straub, J., Hocaoglu, Y., Tilki, D., Strittmatter, F., Zaak, D., Stief, C., and Karl, A. (2010) Urinary cytology in era of fluorescence endoscopy: redefining the role of an established method with a new reference standard. Urology 76, 677-681.
5. Schroeder, G.L., Lorenzo-Gomez, M.F., Hautmann, S.H., Friedrich, M.G., Ekici, S., Huland, H., and Lokeshwar, V. (2004) A side by side comparison of cytology and biomarkers for bladder cancer detection. J. Urol. 172, 1123-1128.
6. Poulakis, V., Witzsch, U., De Vries, R., Altmannsberger, H.M., Manyak, M.J., and Becht, E. (2001) A comparison of urinary nuclear matrix protein-22 and bladder tumour antigen tests with voided urinary cytology in detecting and following bladder cancer: the prognostic value of false-positive results. BJU Int. 88, 692-701.
7. Mowatt, G., Zhu, S., Kilonzo, M., Boachie, C., Fraser, C., Griffiths, T.R.L., N'Dow, J., Nabi, G., Cook, J., and Vale, L. (2010) Systematic review of the clinical effectiveness and cost effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer. Health Technol. Assess. 14, 1-331.
8. van der Poel, H.G., van Balken, M.R., Schamhart, D.H.J., Peelen, P., de Reijke, Th., Debruyne, F.M.J., Schalken, J.A., and Witjes, J.A. (1998) Bladder wash cytology, quantitative cytology, and qualitative BTA test in patients with superficial bladder cancer. Urology 51, 44-50. (Pubitemid 28092504)
9. van der Poel, H.G., Witjes, J.A., van Stratum, P., Bon, M.E., Debruyne, F.M.J., and Schalken, J.A. (1996) Quanticyt: karyometric analysis of bladder washing for patients with superficial bladder cancer. Urology 48, 357-364. (Pubitemid 26317472)
10. van Rhijm, B.W.G., van der Poel, H.G., and van der Kwast, T.H. (2005) Urine markers for bladder cancer surveillance: a systematic review. Eur. Urol. 47, 736-748.
11. Moonen, P.M.J., Merkx, G.F.M., Peelen, P., Karthaus, H.F.M., Smeets, D.F.C.M., and Witjes, J.A. (2007) UroVysion compared with cytology and quantitative cytology in the surveillance of non-muscle invasive bladder cancer. Eur. Urol. 51, 1275-1280. (Pubitemid 46436295)
12. Reid-Nicholson, M.D., Ramalingam, P., Adeagbo, B., Cheng, N., Peiper, S.C., and Terris, M.K. (2009) The use of Urovysion fluorescence in situ hybridization in the diagnosis and surveillance of non-urothelial carcinoma of the bladder. Mod. Pathol. 22, 119-127.
13. Sokolova, I.A., Halling, K.C., Jenkins, R.B., Burkhardt, H.M., Meyer, R.G., Seeilg, S.A., and King, W. (2000) The development of a multitarget, multicolor fluorescence in situ hybridization assay for the detection of urothelial carcinoma in urine. J. Mol. Diagn. 2, 116-123.
14. Friedrich, M.G., Toma, M.I., Hellstern, A., Pantel, K., Weisenberger, D.J., Noldus, J., and Huland, H. (2003) Comparison of multitarget fluorescence in situ hybridization in urine with other noninvasive tests for detecting bladder cancer. BJU Int. 92, 911-914. (Pubitemid 37548264)
15. Sarsody, M.F., Schellhammer, P., Bokinsky, G., Kahn, P., Chao, R., Yore, L., Zadra, J., Burzon, D., Osher, G., Bridge, J.A., Anderson, S., Johansson, S.L., Lieber, M., Soloway, M., and Flom, K. (2002) Clinical evaluation of a multi-target fluorescent in situ hybridization assay for detection of bladder cancer. J. Urol. 168, 1950-1954.
16. Yoo, J.H., Suh, B., Park, T.S., Shin, M.G., Choi, Y., Lee, C.H., and Choi, J.R. (2010) Analysis of fluorescence in situ hybridization, mtDNA quantification, and mtDNA sequence for the detection of early bladder cancer. Cancer Genet. Cytogenet. 198, 107-117.
17. Kipp, B.R., Karnes, R.J., Brankley, S.M., Harwood, A.R., Pankratz, V.S., Sebo, T.J., Blute, M.M., Lieber, M.M., Zincke, H., and Halling, K.C. (2005) Monitoring intravesical therapy for superficial bladder cancer using fluorescence in situ hybridization. J. Urol. 173, 401-404.
18. Carpinto, G.A., Stadler, W.M., Briggman, J.V., Chodak, G.W., Church, P.A., Lamm, D.L., Lange, P.H., Messing, E.M., Pasciak, R.M., Reservitz, G.B., Ross, R.B., Rukstalis, D.B., Sarosdy, M.F., Soloway, M.K., Thiel, R.P., Vogelzang, N., and Hayen, C.L. (1996) Urinary nuclear matrix protein as a marker for transitional cell carcinoma of the urinary tract. J. Urol. 156, 1280-1285. (Pubitemid 26307594)
19. Jamshidian, H., Kor, K., and Djalali, M. (2008) Urine concentration of nuclear matrix protein 22 for diagnosis of transitional cell carcinoma of bladder. Urol. J. 5, 243-247.
20. Grossman, H.B., Messing, E., Soloway, M., Tomera, K., Katz, G., Berger, Y., and Shen, Y. (2005) Detection of bladder cancer using a point of care proteomic assay. JAMA 293, 810-816. (Pubitemid 40250364)
21. Grossman, H.B., Soloway, M., Messing, E., Katz, G., Stein, B., Kassabian, V., and Shen, Y. (2006) Surveillance for recurrent bladder cancer using a point of care proteomic assay. JAMA 295, 299-305. (Pubitemid 43112958)
22. Choi, H.S., Lee, S.I., Kim, D.J., and Jeong, T.Y. (2010) Usefulness of the NMP22BladderChek test for screening and follow-up of bladder cancer. Korean J. Urol. 51, 88-93.
23. Quek, M.L., Sanderson, K., Daneshmand, S., and Stein, J.P. (2004) New molecular markers for bladder cancer detection. Curr. Opin. Urol. 14, 259-264. (Pubitemid 39141981)
24. Mian, C., Maier, K., Comploj, E., Lodde, M., Berner, L., Lusuardi, L., Palermo, S., Vittadello, F., and Pycha, A. (2006) uCyt+/Immunocyt in the detection of recurrent urothelial carcinoma. Cancer Cytopathol. 108, 60-65.
25. Pfister, C., Chautard, D., Devonec, M., Perrin, P., Chopin, D., Rischmann, P., Bouchot, O., Beurton, D., Coulange, C., and Rambeaud, J.J. (2003) Immunocyt test improves the diagnostic accuracy of urinary cytology: results of a French multicenter study. J. Urol. 169, 921-924. (Pubitemid 36188123)
26. Tetu, B., Tiguert, R., Harel, F., and Fradert, Y. (2005) Immunocyt/uCyt+ improves the sensitivity of urine cytology in patients followed for urothelial carcinoma. Mod. Pathol. 18, 83-89. (Pubitemid 40128099)
27. Pode, D., Golijanin, D., Sherman, Y., Lebensart, P., and Shapiro, A. (1998) Immunostaining of Lewis X in cells from voided urine, cytopathology, and ultrasound for noninvasive detection of bladder tumors. J. Urol. 159, 389-393. (Pubitemid 28049239)
28. Planz, B., Striepecke, E., Jakse, G., and Bocking, A. (1998) Use of Lewis X antigen and deoxyribonucleic acid image cytometry to increase sensitivity of urinary cytology in transitional cell carcinoma of the bladder. J. Urol. 159, 384-388. (Pubitemid 28049238)
29. Golijanin, D., Sherman, Y., Shapiro, A., and Pode, D. (1995) Detection of bladder tumors by immunostaining of the Lewis X antigen in cells from voided urine. Urology 46, 179-177.
30. Lokeshwar, V.B. and Soloway, M.S. (2001) Current bladder tumor tests: does their projected utility fulfill clinical necessity? J. Urol. 165, 1067-1077. (Pubitemid 32210202)
31. Schmetter, B.S., Habicht, K.K., Lamm, D.L., Morales, A., Bander, N.H., Grossman, H.B., Hanna, M.G., Silberman, S.R., and Butman, B.T. (1997) A multicenter trial evaluation of the fibrin/fibrinogen degradation products test for detection and monitoring of bladder cancer. J. Urol. 158, 801-805.
32. Ramakumar, S., Bhuiyan, J., Besse, J.A., Roberts, S.G., Wollan, P.C., Blute, M.L., and Okane, D.J. (1999) Comparison of screening methods in the detection of bladder cancer. J. Urol. 161, 388-394.
33. Bavaccini, S., Casadio, V., Amadori, D., Calistri, D., and Silvestrini, R. (2009) The current role of telomerase in the diagnosis of bladder cancer. Indian J. Urol. 25, 40-46.
34. Sanchini, M.A., Gunelli, R., Nanni, O., Bravaccini, S., Fabbri, C., Sermasi, A., Becovich, E., Ravioli, A., Amadori, D., and Calistri, D. (2005) Relevance of urine telomerase in the diagnosis of bladder cancer. JAMA 294, 2052-2056. (Pubitemid 41539938)
35. Erdem, E., Dikmen, G., Atsa, N., Dogan, P., and Ozen, H. (2003) Telomerase activity in diagnosis of bladder cancer. Scand. J. Urol. Nephrol. 37, 205-209. (Pubitemid 36791817)
36. Siracusano, S., Niccolini, B., Knez, R., Tiberio, A., Benedetti, E., Bonin, S., Ciciliato, S., Pappagallo, G.L., Belgrano, E., and Stanta, G. (2005) The simultaneous use of telomerase, cytokeratin 20, and CD4 for bladder cancer detection in urine. Eur. Urol. 47, 327-333. (Pubitemid 40248854)
37. Khalbuss, W. and Goodison, S. (2006) Immunohistochemical detection of hTERT in urothelial lesions: a potential adjunct to urine cytology. Cytojournal 3, 18.
38. Bowles, L., Biakowska-Hobrzanski, H., Bukala, B., Nott, L., and Razvi, H. (2004) A prospective evaluation of the diagnostic and potential prognostic utility of urinary human telomerase reverse transcriptase mRNA in patients with bladder cancer. Can. J. Urol. 11, 2438-2444.
39. Melissourgos, N., Kastrinakis, N.G., Davilas, I., Foukas, P., Farmakis, A., and Lykourinas, M. (2003) Detection of human telomerase reverse transcriptase mRNA in urine of patients with bladder cancer: evaluation of an emerging tumor marker. Urology 62, 362-367. (Pubitemid 36952107)
40. Lokeshwar, V.B., Schroeder, G.L., Selzer, M.G., Hautmann, S.H., Posey, J.T., Watson, R., Rose, L., Markowitz, S., and Soloway, M.S. (2002) Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid-hyaluronidase and BTA-stat tests. Cancer 95, 61-72. (Pubitemid 34743483)
41. Kramer, M.W., Golshani, R., Merseburger, A.S., Knapp, J., Garcia, A., Hennenlotter, J., Duncan, R.C., Soloway, M.S., Jorda, M., Kuczyk, M.A., Stenzl, A., and Lokeshwar, V.B. (2010) HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer. Eur. Urol. 57, 86-94.
42. Lokeshwar, V.B., Gomez, P., Kramer, M., Knapp, J., McCornack, M.A., Lopez, L.E., Freglen, N., Dhir, N., Scherer, S., Klumpp, D.J., Manoharan, M., Soloway, M.S., and Lokeshwar, B.L. (2008) Epigenetic regulation of HYAL-1 hyaluonidase expression: identification of HYAL-1 promoter. J. Biol. Chem. 283, 29215-29227.
43. Lokeshwar, V.B., Obek, C., Pham, H.T., Wei, D., Young, M.J., Duncan, R.C., Soloway, M.S., and Block, N.L. (2000) Urinary hyaluronic acid and hyaluronidase: markers for bladder cancer detection and evaluation of grade. J. Urol. 163, 348-356.
44. Eissa, S., Swellam, M., Shehata, H., El-Khouly, I.M., El-Zayat, T., and El-Ahmady, O. (2010) Expression of HYAL1 and surviving RNA as diagnostic molecular markers for bladder cancer. J. Urol. 183, 493-498.
45. Frigerio, S., Padberg, B.C., Strebel, R.T., Lenggenhager, D.M., Messthaler, A., Abdou, M.T., Moch, H., and Zimmermann, D.R. (2007) Improved detection of bladder carcinoma cells in voided urine by standardized microsatellite analysis. Int. J. Cancer 121, 329-338. (Pubitemid 46917702)
46. Seripa, D., Parrella, P., Gallucci, M., Gravina, C., Papa, S., Fortunato, P., Alcini, A., Flammia, G., Lazzari, M., and Fazio, V.M. (2001) Sensitive detection of transitional cell carcinoma of the bladder by microsatellite analysis of cells exfoliated in urine. Int. J. Cancer 95, 364-369. (Pubitemid 33015106)
47. Wild, P.J., Fuchs, T., Stoehr, R., Zimmermann, D., Frigerio, S., Padberg, B., Steiner, I., Zwarthoff, E.C., Burger, M., Denzinger, S., Hofstaedter, F., Kristiansen, G., Hermanns, T., Seifert, H.H., Provenzano, M., Sulser, T., Roth, V., Buhmann, J.M., Moch, H., and Hartmann, A. (2009) Detection of urothelial bladder cancer cells in voided urine can be improved by a combination of cytology and standardized microsatellite analysis. Cancer Epidemiol. Biomarkers Prev. 18, 1798-1806.
48. Myers-Irvin, J.M., Van Le, T.S., and Getzenberg, R.H. (2005) Mechanistic analysis of the role of BLCA-4 in bladder cancer pathobiology. Cancer Res. 65, 7145-7150. (Pubitemid 41161244)
49. Van Le, T.S., Miller, R., Barder, T., Babjuk, M., Potter, D.M., and Getzenbeg, R.H. (2005) Highly specific urine-based marker of bladder cancer. Urology 66, 1256-1260. (Pubitemid 41797301)
50. Konety, B.R., Nguyen, T.S., Brenes, G., Sholder, A., Lewis, N., Bastacky, S., Potter, D.M., and Getzenberg, R.H. (2000) Clinical usefulness of the novel marker BLCA-4 for the detection of bladder cancer. J. Urol. 164, 634-639. (Pubitemid 30637591)
51. Shirodkar, S.P. and Lokeshwar, V.B. (2009) Potential new markers in the early detection of bladder cancer. Curr. Opin. Urol. 19, 488-493.
52. Alvarez, A. and Lokeshwar, V.B. (2007) Bladder cancer biomarkers: current developments and future implementation. Curr. Opin. Urol. 17, 341-346. (Pubitemid 47344622)
53. Lai, Y., Ye, J., Chen, J., Zhang, L., Wasi, L., He, Z., Zhou, L., Li, H., Yan, Q., Gui, Y., Zhiming, C., Wang, X., and Guan, Z. (2010) UPK3A: a promising novel urinary marker for the detection of bladder cancer. Urology 76, 514e6-514e11.