-
1
-
-
84892961071
-
GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]
-
Lyon, France: International Agency for Research on Cancer. Available from: ; [accessed 2013].
-
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer. Available from: ; 2013 [accessed 2013]. http://globocan.iarc.fr.
-
(2013)
-
-
Ferlay, J.1
Soerjomataram, I.2
Ervik, M.3
Dikshit, R.4
Eser, S.5
Mathers, C.6
-
2
-
-
84892805731
-
Cancer statistics, 2014
-
Siegel R., Ma J., Zou Z., Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014, 64(1):9-29.
-
(2014)
CA Cancer J Clin
, vol.64
, Issue.1
, pp. 9-29
-
-
Siegel, R.1
Ma, J.2
Zou, Z.3
Jemal, A.4
-
3
-
-
84871920581
-
Epidemiology and risk factors of urothelial bladder cancer
-
Burger M., Catto J.W., Dalbagni G., Grossman H.B., Herr H., Karakiewicz P., et al. Epidemiology and risk factors of urothelial bladder cancer. Eur Urol 2013, 63(2):234-241.
-
(2013)
Eur Urol
, vol.63
, Issue.2
, pp. 234-241
-
-
Burger, M.1
Catto, J.W.2
Dalbagni, G.3
Grossman, H.B.4
Herr, H.5
Karakiewicz, P.6
-
4
-
-
32944465832
-
Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials
-
discussion 75-7
-
Sylvester R.J., van der Meijden A.P., Oosterlinck W., Witjes J.A., Bouffioux C., Denis L., et al. Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol 2006, 49(3):465-466. discussion 75-7.
-
(2006)
Eur Urol
, vol.49
, Issue.3
, pp. 465-466
-
-
Sylvester, R.J.1
van der Meijden, A.P.2
Oosterlinck, W.3
Witjes, J.A.4
Bouffioux, C.5
Denis, L.6
-
5
-
-
0041429507
-
Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer
-
Grossman H.B., Natale R.B., Tangen C.M., Speights V.O., Vogelzang N.J., Trump D.L., et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med 2003, 349(9):859-866.
-
(2003)
N Engl J Med
, vol.349
, Issue.9
, pp. 859-866
-
-
Grossman, H.B.1
Natale, R.B.2
Tangen, C.M.3
Speights, V.O.4
Vogelzang, N.J.5
Trump, D.L.6
-
6
-
-
23044501890
-
Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer
-
von der Maase H., Sengelov L., Roberts J.T., Ricci S., Dogliotti L., Oliver T., et al. Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol 2005, 23(21):4602-4608.
-
(2005)
J Clin Oncol
, vol.23
, Issue.21
, pp. 4602-4608
-
-
von der Maase, H.1
Sengelov, L.2
Roberts, J.T.3
Ricci, S.4
Dogliotti, L.5
Oliver, T.6
-
7
-
-
84897022815
-
Comprehensive molecular characterization of urothelial bladder carcinoma
-
Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 2014;507(7492):315-22.
-
(2014)
Nature
, vol.507
, Issue.7492
, pp. 315-322
-
-
-
8
-
-
61649100307
-
The FGF family: biology, pathophysiology and therapy
-
Beenken A., Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discovery 2009, 8(3):235-253.
-
(2009)
Nat Rev Drug Discovery
, vol.8
, Issue.3
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
9
-
-
84921660006
-
A network map of FGF-1/FGFR signaling system
-
Raju R, Palapetta SM, Sandhya VK, Sahu A, Alipoor A, Balakrishnan L. A network map of FGF-1/FGFR signaling system. 2014;2014:962962.
-
(2014)
, vol.2014
, pp. 962962
-
-
Raju, R.1
Palapetta, S.M.2
Sandhya, V.K.3
Sahu, A.4
Alipoor, A.5
Balakrishnan, L.6
-
10
-
-
3242700634
-
Signaling, internalization, and intracellular activity of fibroblast growth factor
-
Pandey A., Gowda H., Wiedlocha A., Sorensen V. Signaling, internalization, and intracellular activity of fibroblast growth factor. J Signal Transduct 2004, 286:45-79.
-
(2004)
J Signal Transduct
, vol.286
, pp. 45-79
-
-
Pandey, A.1
Gowda, H.2
Wiedlocha, A.3
Sorensen, V.4
-
11
-
-
0035874067
-
An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release
-
Aigner A., Butscheid M., Kunkel P., Krause E., Lamszus K., Wellstein A., et al. An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release. Int J Cancer J Int Cancer 2001, 92(4):510-517.
-
(2001)
Int J Cancer J Int Cancer
, vol.92
, Issue.4
, pp. 510-517
-
-
Aigner, A.1
Butscheid, M.2
Kunkel, P.3
Krause, E.4
Lamszus, K.5
Wellstein, A.6
-
12
-
-
0032559228
-
Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
-
Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 1998, 92(2):253-263.
-
(1998)
Cell
, vol.92
, Issue.2
, pp. 253-263
-
-
Hacohen, N.1
Kramer, S.2
Sutherland, D.3
Hiromi, Y.4
Krasnow, M.A.5
-
13
-
-
0035958277
-
Identification of a new fibroblast growth factor receptor, FGFR5
-
Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., et al. Identification of a new fibroblast growth factor receptor, FGFR5. Gene 2001, 271(2):171-182.
-
(2001)
Gene
, vol.271
, Issue.2
, pp. 171-182
-
-
Sleeman, M.1
Fraser, J.2
McDonald, M.3
Yuan, S.4
White, D.5
Grandison, P.6
-
14
-
-
0028046606
-
A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome
-
Muenke M., Schell U., Hehr A., Robin N.H., Losken H.W., Schinzel A., et al. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat Genet 1994, 8(3):269-274.
-
(1994)
Nat Genet
, vol.8
, Issue.3
, pp. 269-274
-
-
Muenke, M.1
Schell, U.2
Hehr, A.3
Robin, N.H.4
Losken, H.W.5
Schinzel, A.6
-
15
-
-
20244366799
-
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome
-
Dode C., Levilliers J., Dupont J.M., De Paepe A., Le Du N., Soussi-Yanicostas N., et al. Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Nat Genet 2003, 33(4):463-465.
-
(2003)
Nat Genet
, vol.33
, Issue.4
, pp. 463-465
-
-
Dode, C.1
Levilliers, J.2
Dupont, J.M.3
De Paepe, A.4
Le Du, N.5
Soussi-Yanicostas, N.6
-
16
-
-
0029935895
-
Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
-
Naski M.C., Wang Q., Xu J., Ornitz D.M. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 1996, 13(2):233-237.
-
(1996)
Nat Genet
, vol.13
, Issue.2
, pp. 233-237
-
-
Naski, M.C.1
Wang, Q.2
Xu, J.3
Ornitz, D.M.4
-
17
-
-
26444481568
-
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
-
Rand V., Huang J., Stockwell T., Ferriera S., Buzko O., Levy S., et al. Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci USA 2005, 102(40):14344-14349.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.40
, pp. 14344-14349
-
-
Rand, V.1
Huang, J.2
Stockwell, T.3
Ferriera, S.4
Buzko, O.5
Levy, S.6
-
18
-
-
0032954333
-
Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer
-
Giri D., Ropiquet F., Ittmann M. Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer. Clin Cancer Res 1999, 5(5):1063-1071.
-
(1999)
Clin Cancer Res
, vol.5
, Issue.5
, pp. 1063-1071
-
-
Giri, D.1
Ropiquet, F.2
Ittmann, M.3
-
19
-
-
41649097333
-
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
-
Antoniou A.C., Spurdle A.B., Sinilnikova O.M., Healey S., Pooley K.A., Schmutzler R.K., et al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 2008, 82(4):937-948.
-
(2008)
Am J Hum Genet
, vol.82
, Issue.4
, pp. 937-948
-
-
Antoniou, A.C.1
Spurdle, A.B.2
Sinilnikova, O.M.3
Healey, S.4
Pooley, K.A.5
Schmutzler, R.K.6
-
20
-
-
0030922231
-
Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
-
Chesi M., Nardini E., Brents L.A., Schrock E., Ried T., Kuehl W.M., et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997, 16(3):260-264.
-
(1997)
Nat Genet
, vol.16
, Issue.3
, pp. 260-264
-
-
Chesi, M.1
Nardini, E.2
Brents, L.A.3
Schrock, E.4
Ried, T.5
Kuehl, W.M.6
-
21
-
-
3142726255
-
Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma
-
Streit S., Bange J., Fichtner A., Ihrler S., Issing W., Ullrich A. Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma. Int J Cancer J Int Cancer 2004, 111(2):213-217.
-
(2004)
Int J Cancer J Int Cancer
, vol.111
, Issue.2
, pp. 213-217
-
-
Streit, S.1
Bange, J.2
Fichtner, A.3
Ihrler, S.4
Issing, W.5
Ullrich, A.6
-
22
-
-
0032841519
-
Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
-
Cappellen D., De Oliveira C., Ricol D., de Medina S., Bourdin J., Sastre-Garau X., et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet 1999, 23(1):18-20.
-
(1999)
Nat Genet
, vol.23
, Issue.1
, pp. 18-20
-
-
Cappellen, D.1
De Oliveira, C.2
Ricol, D.3
de Medina, S.4
Bourdin, J.5
Sastre-Garau, X.6
-
23
-
-
0035825598
-
Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma
-
Sibley K., Cuthbert-Heavens D., Knowles M.A. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Oncogene 2001, 20(6):686-691.
-
(2001)
Oncogene
, vol.20
, Issue.6
, pp. 686-691
-
-
Sibley, K.1
Cuthbert-Heavens, D.2
Knowles, M.A.3
-
24
-
-
84864917826
-
A decade of FGF receptor research in bladder cancer: past, present, and future challenges
-
di Martino E., Tomlinson D.C., Knowles M.A. A decade of FGF receptor research in bladder cancer: past, present, and future challenges. Adv Urol 2012, 2012:429213.
-
(2012)
Adv Urol
, vol.2012
, pp. 429213
-
-
di Martino, E.1
Tomlinson, D.C.2
Knowles, M.A.3
-
25
-
-
84921678808
-
The FGFR landscape in cancer: an analysis of 4,869 cases
-
[abstr 11059]
-
Helsten T.L.E., SK, Carter J., Kurzrock R. The FGFR landscape in cancer: an analysis of 4,869 cases. J Clin Oncol 2014, 32(5s). [abstr 11059].
-
(2014)
J Clin Oncol
, vol.32
, Issue.5 s
-
-
Helsten, T.L.E.1
S.K.2
Carter, J.3
Kurzrock, R.4
-
26
-
-
34548407864
-
FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
-
Tomlinson D.C., Baldo O., Harnden P., Knowles M.A. FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J Pathol 2007, 213(1):91-98.
-
(2007)
J Pathol
, vol.213
, Issue.1
, pp. 91-98
-
-
Tomlinson, D.C.1
Baldo, O.2
Harnden, P.3
Knowles, M.A.4
-
27
-
-
84859402751
-
Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models
-
Gozgit J.M., Wong M.J., Moran L., Wardwell S., Mohemmad Q.K., Narasimhan N.I., et al. Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models. Mol Cancer Ther 2012, 11(3):690-699.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.3
, pp. 690-699
-
-
Gozgit, J.M.1
Wong, M.J.2
Moran, L.3
Wardwell, S.4
Mohemmad, Q.K.5
Narasimhan, N.I.6
-
28
-
-
81055124246
-
A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models
-
Zhao G., Li W.Y., Chen D., Henry J.R., Li H.Y., Chen Z., et al. A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models. Mol Cancer Ther 2011, 10(11):2200-2210.
-
(2011)
Mol Cancer Ther
, vol.10
, Issue.11
, pp. 2200-2210
-
-
Zhao, G.1
Li, W.Y.2
Chen, D.3
Henry, J.R.4
Li, H.Y.5
Chen, Z.6
-
29
-
-
84879417823
-
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance
-
Chell V., Balmanno K., Little A.S., Wilson M., Andrews S., Blockley L., et al. Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance. Oncogene 2013, 32(25):3059-3070.
-
(2013)
Oncogene
, vol.32
, Issue.25
, pp. 3059-3070
-
-
Chell, V.1
Balmanno, K.2
Little, A.S.3
Wilson, M.4
Andrews, S.5
Blockley, L.6
-
30
-
-
84920924071
-
Phase 1 study of JNJ-42756493, a pan-fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced solid tumors
-
[abstr 2501]
-
Bahleda R., Dienstmann R., Adamo B., Gazzah A., Infante J.R. Phase 1 study of JNJ-42756493, a pan-fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced solid tumors. J Clin Oncol 2014, 32(5s). [abstr 2501].
-
(2014)
J Clin Oncol
, vol.32
, Issue.5 s
-
-
Bahleda, R.1
Dienstmann, R.2
Adamo, B.3
Gazzah, A.4
Infante, J.R.5
-
31
-
-
84865441732
-
Role of FGFs/FGFRs in skeletal development and bone regeneration
-
Du X., Xie Y., Xian C.J., Chen L. Role of FGFs/FGFRs in skeletal development and bone regeneration. J Cell Physiol 2012, 227(12):3731-3743.
-
(2012)
J Cell Physiol
, vol.227
, Issue.12
, pp. 3731-3743
-
-
Du, X.1
Xie, Y.2
Xian, C.J.3
Chen, L.4
-
32
-
-
84941811376
-
Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors.
-
Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr CT326].
-
Sequist LV, Cassier P, Varga A, Tabernero J, Schellens JHM, Delord J, et al. Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors. In: Proceedings of the 105th annual meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr CT326].
-
(2014)
Proceedings of the 105th annual meeting of the American Association for Cancer Research
-
-
Sequist, L.V.1
Cassier, P.2
Varga, A.3
Tabernero, J.4
Schellens, J.H.M.5
Delord, J.6
-
33
-
-
84921678806
-
A phase I trial of LY2874455, a fibroblast growth factor receptor inhibitor, in patients with advanced cancer
-
Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr CT215 2014].
-
Tie J, Bang Y, Park YS, Kang Y, Monteith D, Hartsock K, et al. A phase I trial of LY2874455, a fibroblast growth factor receptor inhibitor, in patients with advanced cancer. In: Proceedings of the 105th annual meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr CT215 2014].
-
(2014)
Proceedings of the 105th annual meeting of the American Association for Cancer Research
-
-
Tie, J.1
Bang, Y.2
Park, Y.S.3
Kang, Y.4
Monteith, D.5
Hartsock, K.6
-
34
-
-
84888883099
-
Final results of a multicenter, open-label phase II trial of dovitinib (TKI258) in patients with advanced urothelial carcinoma with either mutated or nonmutated FGFR3
-
[abstr 255]
-
Milowsky M.I., Dittrich C., Martinez I.D., Jagdev S., Millard F.E., Sweeney C., et al. Final results of a multicenter, open-label phase II trial of dovitinib (TKI258) in patients with advanced urothelial carcinoma with either mutated or nonmutated FGFR3. J Clin Oncol 2013, 31(Suppl. 6). [abstr 255].
-
(2013)
J Clin Oncol
, vol.31
-
-
Milowsky, M.I.1
Dittrich, C.2
Martinez, I.D.3
Jagdev, S.4
Millard, F.E.5
Sweeney, C.6
-
35
-
-
70349667473
-
Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer
-
Platt F.M., Hurst C.D., Taylor C.F., Gregory W.M., Harnden P., Knowles M.A. Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer. Clin Cancer Res 2009, 15(19):6008-6017.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.19
, pp. 6008-6017
-
-
Platt, F.M.1
Hurst, C.D.2
Taylor, C.F.3
Gregory, W.M.4
Harnden, P.5
Knowles, M.A.6
-
36
-
-
73849134249
-
AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K
-
Askham J.M., Platt F., Chambers P.A., Snowden H., Taylor C.F., Knowles M.A. AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. Oncogene 2010, 29(1):150-155.
-
(2010)
Oncogene
, vol.29
, Issue.1
, pp. 150-155
-
-
Askham, J.M.1
Platt, F.2
Chambers, P.A.3
Snowden, H.4
Taylor, C.F.5
Knowles, M.A.6
-
37
-
-
79955012093
-
A systematic study of gene mutations in urothelial carcinoma; inactivating mutations in TSC2 and PIK3R1
-
Sjodahl G., Lauss M., Gudjonsson S., Liedberg F., Hallden C., Chebil G., et al. A systematic study of gene mutations in urothelial carcinoma; inactivating mutations in TSC2 and PIK3R1. PLoS ONE 2011, 6(4):e18583.
-
(2011)
PLoS ONE
, vol.6
, Issue.4
, pp. e18583
-
-
Sjodahl, G.1
Lauss, M.2
Gudjonsson, S.3
Liedberg, F.4
Hallden, C.5
Chebil, G.6
-
38
-
-
84926259180
-
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment of bladder cancers
-
Houede N., Pourquier P. Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment of bladder cancers. Pharmacol Ther 2014.
-
(2014)
Pharmacol Ther
-
-
Houede, N.1
Pourquier, P.2
-
39
-
-
84904555503
-
Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
-
Rodon J., Brana I., Siu L.L., De Jonge M.J., Homji N., Mills D., et al. Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. Invest New Drugs 2014, 32(4):670-681.
-
(2014)
Invest New Drugs
, vol.32
, Issue.4
, pp. 670-681
-
-
Rodon, J.1
Brana, I.2
Siu, L.L.3
De Jonge, M.J.4
Homji, N.5
Mills, D.6
-
40
-
-
79955118584
-
Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells
-
Wu D., Tao J., Xu B., Qing W., Li P., Lu Q., et al. Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells. Urol Int 2011, 86(3):346-354.
-
(2011)
Urol Int
, vol.86
, Issue.3
, pp. 346-354
-
-
Wu, D.1
Tao, J.2
Xu, B.3
Qing, W.4
Li, P.5
Lu, Q.6
-
41
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly K.E., Rojo F., She Q.B., Solit D., Mills G.B., Smith D., et al. MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006, 66(3):1500-1508.
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
-
42
-
-
84904397559
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells
-
Moon du G., Lee S.E., Oh M.M., Lee S.C., Jeong S.J., Hong S.K., et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells. Int J Oncol 2014, 45(3):1027-1035.
-
(2014)
Int J Oncol
, vol.45
, Issue.3
, pp. 1027-1035
-
-
Moon du, G.1
Lee, S.E.2
Oh, M.M.3
Lee, S.C.4
Jeong, S.J.5
Hong, S.K.6
-
43
-
-
84896046724
-
Patient-derived xenografts reveal limits to PI3K/mTOR- and MEK-mediated inhibition of bladder cancer
-
Cirone P., Andresen C.J., Eswaraka J.R., Lappin P.B., Bagi C.M. Patient-derived xenografts reveal limits to PI3K/mTOR- and MEK-mediated inhibition of bladder cancer. Cancer Chemother Pharmacol 2014, 73(3):525-538.
-
(2014)
Cancer Chemother Pharmacol
, vol.73
, Issue.3
, pp. 525-538
-
-
Cirone, P.1
Andresen, C.J.2
Eswaraka, J.R.3
Lappin, P.B.4
Bagi, C.M.5
-
44
-
-
84921626508
-
A phase 1b dose-escalation study of BYL719 plus binimetinib (MEK162) in patients with selected advanced solid tumors
-
[abstr 9051]
-
Juric D., Soria J., Sharma S., Benerji U., Azaro A., Desai J., et al. A phase 1b dose-escalation study of BYL719 plus binimetinib (MEK162) in patients with selected advanced solid tumors. J Clinical Oncol 2014, 32(5s). [abstr 9051].
-
(2014)
J Clinical Oncol
, vol.32
, Issue.5 s
-
-
Juric, D.1
Soria, J.2
Sharma, S.3
Benerji, U.4
Azaro, A.5
Desai, J.6
-
45
-
-
0036345448
-
Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours
-
Crul M., Rosing H., de Klerk G.J., Dubbelman R., Traiser M., Reichert S., et al. Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours. Eur J Cancer 2002, 38(12):1615-1621.
-
(2002)
Eur J Cancer
, vol.38
, Issue.12
, pp. 1615-1621
-
-
Crul, M.1
Rosing, H.2
de Klerk, G.J.3
Dubbelman, R.4
Traiser, M.5
Reichert, S.6
-
46
-
-
84884261429
-
Perifosine - a new option in treatment of acute myeloid leukemia?
-
Krawczyk J., Keane N., Swords R., O'Dwyer M., Freeman C.L., Giles F.J. Perifosine - a new option in treatment of acute myeloid leukemia?. Expert Opin Investig Drugs 2013, 22(10):1315-1327.
-
(2013)
Expert Opin Investig Drugs
, vol.22
, Issue.10
, pp. 1315-1327
-
-
Krawczyk, J.1
Keane, N.2
Swords, R.3
O'Dwyer, M.4
Freeman, C.L.5
Giles, F.J.6
-
47
-
-
84862738897
-
Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background
-
Davies B.R., Greenwood H., Dudley P., Crafter C., Yu D.H., Zhang J., et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther 2012, 11(4):873-887.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.4
, pp. 873-887
-
-
Davies, B.R.1
Greenwood, H.2
Dudley, P.3
Crafter, C.4
Yu, D.H.5
Zhang, J.6
-
48
-
-
84880781405
-
Phase II study of everolimus in metastatic urothelial cancer
-
Milowsky M.I., Iyer G., Regazzi A.M., Al-Ahmadie H., Gerst S.R., Ostrovnaya I., et al. Phase II study of everolimus in metastatic urothelial cancer. BJU Int 2013, 112(4):462-470.
-
(2013)
BJU Int
, vol.112
, Issue.4
, pp. 462-470
-
-
Milowsky, M.I.1
Iyer, G.2
Regazzi, A.M.3
Al-Ahmadie, H.4
Gerst, S.R.5
Ostrovnaya, I.6
-
49
-
-
84867333656
-
Genome sequencing identifies a basis for everolimus sensitivity
-
Iyer G., Hanrahan A.J., Milowsky M.I., Al-Ahmadie H., Scott S.N., Janakiraman M., et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 2012, 338(6104):221.
-
(2012)
Science
, vol.338
, Issue.6104
, pp. 221
-
-
Iyer, G.1
Hanrahan, A.J.2
Milowsky, M.I.3
Al-Ahmadie, H.4
Scott, S.N.5
Janakiraman, M.6
-
50
-
-
84864369495
-
Phase II study of everolimus in patients with locally advanced or metastatic transitional cell carcinoma of the urothelial tract: clinical activity, molecular response, and biomarkers
-
Seront E., Rottey S., Sautois B., Kerger J., D'Hondt L.A., Verschaeve V., et al. Phase II study of everolimus in patients with locally advanced or metastatic transitional cell carcinoma of the urothelial tract: clinical activity, molecular response, and biomarkers. Ann Oncol 2012, 23(10):2663-2670.
-
(2012)
Ann Oncol
, vol.23
, Issue.10
, pp. 2663-2670
-
-
Seront, E.1
Rottey, S.2
Sautois, B.3
Kerger, J.4
D'Hondt, L.A.5
Verschaeve, V.6
-
51
-
-
84868000731
-
A phase II trial of temsirolimus in second-line metastatic urothelial cancer
-
Gerullis H., Eimer C., Ecke T.H., Georgas E., Freitas C., Kastenholz S., et al. A phase II trial of temsirolimus in second-line metastatic urothelial cancer. Med Oncol 2012, 29(4):2870-2876.
-
(2012)
Med Oncol
, vol.29
, Issue.4
, pp. 2870-2876
-
-
Gerullis, H.1
Eimer, C.2
Ecke, T.H.3
Georgas, E.4
Freitas, C.5
Kastenholz, S.6
-
52
-
-
84897087742
-
The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro
-
Becker M.N., Wu K.J., Marlow L.A., Kreinest P.A., Vonroemeling C.A., Copland J.A., et al. The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro. Urol Oncol 2014, 32(3):317-326.
-
(2014)
Urol Oncol
, vol.32
, Issue.3
, pp. 317-326
-
-
Becker, M.N.1
Wu, K.J.2
Marlow, L.A.3
Kreinest, P.A.4
Vonroemeling, C.A.5
Copland, J.A.6
-
53
-
-
79959556990
-
Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours
-
Fleischmann A., Rotzer D., Seiler R., Studer U.E., Thalmann G.N. Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours. Eur Urol 2011, 60(2):350-357.
-
(2011)
Eur Urol
, vol.60
, Issue.2
, pp. 350-357
-
-
Fleischmann, A.1
Rotzer, D.2
Seiler, R.3
Studer, U.E.4
Thalmann, G.N.5
-
54
-
-
84873918443
-
Activating HER2 mutations in HER2 gene amplification negative breast cancer
-
Bose R., Kavuri S.M., Searleman A.C., Shen W., Shen D., Koboldt D.C., et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discovery 2013, 3(2):224-237.
-
(2013)
Cancer Discovery
, vol.3
, Issue.2
, pp. 224-237
-
-
Bose, R.1
Kavuri, S.M.2
Searleman, A.C.3
Shen, W.4
Shen, D.5
Koboldt, D.C.6
-
55
-
-
84892170782
-
A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma
-
Ross J.S., Wang K., Gay L.M., Al-Rohil R.N., Nazeer T., Sheehan C.E., et al. A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma. Clin Cancer Res 2014, 20(1):68-75.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.1
, pp. 68-75
-
-
Ross, J.S.1
Wang, K.2
Gay, L.M.3
Al-Rohil, R.N.4
Nazeer, T.5
Sheehan, C.E.6
-
56
-
-
84866983438
-
Clinical significance of ErbB receptor family in urothelial carcinoma of the bladder: a systematic review and meta-analysis
-
Tsai Y.S., Cheng H.L., Tzai T.S., Chow N.H. Clinical significance of ErbB receptor family in urothelial carcinoma of the bladder: a systematic review and meta-analysis. Adv Urol 2012, 2012:181964.
-
(2012)
Adv Urol
, vol.2012
, pp. 181964
-
-
Tsai, Y.S.1
Cheng, H.L.2
Tzai, T.S.3
Chow, N.H.4
-
57
-
-
84921660005
-
Prognostic value of HER2 expression in patients with bladder cancer treated with radical cystectomy: a biomarker study
-
[abstr e15515]
-
Erben P., Wirtz R.M., Martini T., Trunk M.J., Hofheinz R., Michel M.S., et al. Prognostic value of HER2 expression in patients with bladder cancer treated with radical cystectomy: a biomarker study. J Clin Oncol 2014, 32. [abstr e15515].
-
(2014)
J Clin Oncol
, vol.32
-
-
Erben, P.1
Wirtz, R.M.2
Martini, T.3
Trunk, M.J.4
Hofheinz, R.5
Michel, M.S.6
-
58
-
-
34250218955
-
Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trial
-
Hussain M.H., MacVicar G.R., Petrylak D.P., Dunn R.L., Vaishampayan U., Lara P.N., et al. Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trial. J Clin Oncol 2007, 25(16):2218-2224.
-
(2007)
J Clin Oncol
, vol.25
, Issue.16
, pp. 2218-2224
-
-
Hussain, M.H.1
MacVicar, G.R.2
Petrylak, D.P.3
Dunn, R.L.4
Vaishampayan, U.5
Lara, P.N.6
-
59
-
-
67649579849
-
A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma
-
Wulfing C., Machiels J.P., Richel D.J., Grimm M.O., Treiber U., De Groot M.R., et al. A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma. Cancer 2009, 115(13):2881-2890.
-
(2009)
Cancer
, vol.115
, Issue.13
, pp. 2881-2890
-
-
Wulfing, C.1
Machiels, J.P.2
Richel, D.J.3
Grimm, M.O.4
Treiber, U.5
De Groot, M.R.6
-
60
-
-
84921672100
-
Targeting HER2 with trastuzumab-DM1 (T-DM1) in HER2-overexpressing bladder cancer
-
Hayashi T., Jaeger W., Moskalev I., Awrey S., Li N., Fazli L. Targeting HER2 with trastuzumab-DM1 (T-DM1) in HER2-overexpressing bladder cancer. J Urol 2014, 191(4s):e301.
-
(2014)
J Urol
, vol.191
, Issue.4 s
, pp. e301
-
-
Hayashi, T.1
Jaeger, W.2
Moskalev, I.3
Awrey, S.4
Li, N.5
Fazli, L.6
-
61
-
-
84907062518
-
A phase 1 study of MM-111, a bispecific HER2/HER3 antibody fusion protein, combined with multiple treatment regimens in patients with advanced HER2-positive solid tumors
-
[abstr 651]
-
Richards D.A., Braiteh F.S., Garcia A.A., Denlinger C.S., Conkling P.R., Edenfield W.J., et al. A phase 1 study of MM-111, a bispecific HER2/HER3 antibody fusion protein, combined with multiple treatment regimens in patients with advanced HER2-positive solid tumors. J Clin Oncol 2014, 32(5s). [abstr 651].
-
(2014)
J Clin Oncol
, vol.32
, Issue.5 s
-
-
Richards, D.A.1
Braiteh, F.S.2
Garcia, A.A.3
Denlinger, C.S.4
Conkling, P.R.5
Edenfield, W.J.6
-
62
-
-
84921683978
-
Preliminary product parameter and safety results from NeuACT, a phase 2 randomized, open-label trial of DN24-02 in patients with surgically resected HER2+ urothelial cancer at high risk for recurrence
-
[abstract 4541]
-
Bajorin D.F., Gomella L.G., Sharma P., Plimack E.R., O'Donnell P.H., Hoffman-Censits J.H., et al. Preliminary product parameter and safety results from NeuACT, a phase 2 randomized, open-label trial of DN24-02 in patients with surgically resected HER2+ urothelial cancer at high risk for recurrence. J Clin Oncol 2014, 32(5s). [abstract 4541].
-
(2014)
J Clin Oncol
, vol.32
, Issue.5 s
-
-
Bajorin, D.F.1
Gomella, L.G.2
Sharma, P.3
Plimack, E.R.4
O'Donnell, P.H.5
Hoffman-Censits, J.H.6
-
63
-
-
0031714080
-
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
-
Zhou H., Kuang J., Zhong L., Kuo W.L., Gray J.W., Sahin A., et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998, 20(2):189-193.
-
(1998)
Nat Genet
, vol.20
, Issue.2
, pp. 189-193
-
-
Zhou, H.1
Kuang, J.2
Zhong, L.3
Kuo, W.L.4
Gray, J.W.5
Sahin, A.6
-
64
-
-
0033532869
-
Mitotic kinase expression and colorectal cancer progression
-
Katayama H., Ota T., Jisaki F., Ueda Y., Tanaka T., Odashima S., et al. Mitotic kinase expression and colorectal cancer progression. J Natl Cancer Inst 1999, 91(13):1160-1162.
-
(1999)
J Natl Cancer Inst
, vol.91
, Issue.13
, pp. 1160-1162
-
-
Katayama, H.1
Ota, T.2
Jisaki, F.3
Ueda, Y.4
Tanaka, T.5
Odashima, S.6
-
65
-
-
0032100685
-
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
-
Bischoff J.R., Anderson L., Zhu Y., Mossie K., Ng L., Souza B., et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 1998, 17(11):3052-3065.
-
(1998)
EMBO J
, vol.17
, Issue.11
, pp. 3052-3065
-
-
Bischoff, J.R.1
Anderson, L.2
Zhu, Y.3
Mossie, K.4
Ng, L.5
Souza, B.6
-
66
-
-
0030962953
-
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
-
Sen S., Zhou H., White R.A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 1997, 14(18):2195-2200.
-
(1997)
Oncogene
, vol.14
, Issue.18
, pp. 2195-2200
-
-
Sen, S.1
Zhou, H.2
White, R.A.3
-
67
-
-
2142746397
-
The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas
-
Reichardt W., Jung V., Brunner C., Klein A., Wemmert S., Romeike B.F., et al. The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas. Oncol Rep 2003, 10(5):1275-1279.
-
(2003)
Oncol Rep
, vol.10
, Issue.5
, pp. 1275-1279
-
-
Reichardt, W.1
Jung, V.2
Brunner, C.3
Klein, A.4
Wemmert, S.5
Romeike, B.F.6
-
68
-
-
79851488677
-
Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms
-
Bufo P., Sanguedolce F., Tortorella S., Cormio L., Carrieri G., Pannone G. Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms. Histol Histopathol 2010, 25(11):1371-1377.
-
(2010)
Histol Histopathol
, vol.25
, Issue.11
, pp. 1371-1377
-
-
Bufo, P.1
Sanguedolce, F.2
Tortorella, S.3
Cormio, L.4
Carrieri, G.5
Pannone, G.6
-
69
-
-
53149125697
-
Gene expression study of Aurora-A reveals implication during bladder carcinogenesis and increasing values in invasive urothelial cancer
-
Comperat E., Bieche I., Dargere D., Laurendeau I., Vieillefond A., Benoit G., et al. Gene expression study of Aurora-A reveals implication during bladder carcinogenesis and increasing values in invasive urothelial cancer. Urology 2008, 72(4):873-877.
-
(2008)
Urology
, vol.72
, Issue.4
, pp. 873-877
-
-
Comperat, E.1
Bieche, I.2
Dargere, D.3
Laurendeau, I.4
Vieillefond, A.5
Benoit, G.6
-
70
-
-
84873570889
-
MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia
-
Giles F.J., Swords R.T., Nagler A., Hochhaus A., Ottmann O.G., Rizzieri D.A., et al. MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Leukemia 2013, 27(1):113-117.
-
(2013)
Leukemia
, vol.27
, Issue.1
, pp. 113-117
-
-
Giles, F.J.1
Swords, R.T.2
Nagler, A.3
Hochhaus, A.4
Ottmann, O.G.5
Rizzieri, D.A.6
-
71
-
-
84877099149
-
The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
-
Zhou N., Singh K., Mir M.C., Parker Y., Lindner D., Dreicer R., et al. The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clin Cancer Res 2013, 19(7):1717-1728.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.7
, pp. 1717-1728
-
-
Zhou, N.1
Singh, K.2
Mir, M.C.3
Parker, Y.4
Lindner, D.5
Dreicer, R.6
-
72
-
-
79954448918
-
Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors
-
Dees E.C., Infante J.R., Cohen R.B., O'Neil B.H., Jones S., von Mehren M., et al. Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors. Cancer Chemother Pharmacol 2011, 67(4):945-954.
-
(2011)
Cancer Chemother Pharmacol
, vol.67
, Issue.4
, pp. 945-954
-
-
Dees, E.C.1
Infante, J.R.2
Cohen, R.B.3
O'Neil, B.H.4
Jones, S.5
von Mehren, M.6
-
73
-
-
77958042173
-
Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: safety, pharmacokinetics, and pharmacodynamics
-
Macarulla T., Cervantes A., Elez E., Rodriguez-Braun E., Baselga J., Rosello S., et al. Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: safety, pharmacokinetics, and pharmacodynamics. Mol Cancer Ther 2010, 9(10):2844-2852.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.10
, pp. 2844-2852
-
-
Macarulla, T.1
Cervantes, A.2
Elez, E.3
Rodriguez-Braun, E.4
Baselga, J.5
Rosello, S.6
-
74
-
-
3242792692
-
Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades
-
Weichert W., Schmidt M., Gekeler V., Denkert C., Stephan C., Jung K., et al. Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades. Prostate 2004, 60(3):240-245.
-
(2004)
Prostate
, vol.60
, Issue.3
, pp. 240-245
-
-
Weichert, W.1
Schmidt, M.2
Gekeler, V.3
Denkert, C.4
Stephan, C.5
Jung, K.6
-
75
-
-
13244271313
-
Polo-like kinases (Plks) and cancer
-
Takai N., Hamanaka R., Yoshimatsu J., Miyakawa I. Polo-like kinases (Plks) and cancer. Oncogene 2005, 24(2):287-291.
-
(2005)
Oncogene
, vol.24
, Issue.2
, pp. 287-291
-
-
Takai, N.1
Hamanaka, R.2
Yoshimatsu, J.3
Miyakawa, I.4
-
76
-
-
20144387142
-
Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer
-
Nogawa M., Yuasa T., Kimura S., Tanaka M., Kuroda J., Sato K., et al. Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. J Clin Investig 2005, 115(4):978-985.
-
(2005)
J Clin Investig
, vol.115
, Issue.4
, pp. 978-985
-
-
Nogawa, M.1
Yuasa, T.2
Kimura, S.3
Tanaka, M.4
Kuroda, J.5
Sato, K.6
-
77
-
-
33746622832
-
Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer
-
Yamamoto Y., Matsuyama H., Kawauchi S., Matsumoto H., Nagao K., Ohmi C., et al. Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer. Oncology 2006, 70(3):231-237.
-
(2006)
Oncology
, vol.70
, Issue.3
, pp. 231-237
-
-
Yamamoto, Y.1
Matsuyama, H.2
Kawauchi, S.3
Matsumoto, H.4
Nagao, K.5
Ohmi, C.6
-
78
-
-
0037013326
-
The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk
-
Golan A., Yudkovsky Y., Hershko A. The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J Biol Chem 2002, 277(18):15552-15557.
-
(2002)
J Biol Chem
, vol.277
, Issue.18
, pp. 15552-15557
-
-
Golan, A.1
Yudkovsky, Y.2
Hershko, A.3
-
79
-
-
0036209010
-
The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase
-
Sumara I., Vorlaufer E., Stukenberg P.T., Kelm O., Redemann N., Nigg E.A., et al. The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase. Mol Cell 2002, 9(3):515-525.
-
(2002)
Mol Cell
, vol.9
, Issue.3
, pp. 515-525
-
-
Sumara, I.1
Vorlaufer, E.2
Stukenberg, P.T.3
Kelm, O.4
Redemann, N.5
Nigg, E.A.6
-
80
-
-
65649105075
-
BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity
-
Rudolph D., Steegmaier M., Hoffmann M., Grauert M., Baum A., Quant J., et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin Cancer Res 2009, 15(9):3094-3102.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.9
, pp. 3094-3102
-
-
Rudolph, D.1
Steegmaier, M.2
Hoffmann, M.3
Grauert, M.4
Baum, A.5
Quant, J.6
-
81
-
-
84655164874
-
A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours
-
Schoffski P., Awada A., Dumez H., Gil T., Bartholomeus S., Wolter P., et al. A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours. Eur J Cancer 2012, 48(2):179-186.
-
(2012)
Eur J Cancer
, vol.48
, Issue.2
, pp. 179-186
-
-
Schoffski, P.1
Awada, A.2
Dumez, H.3
Gil, T.4
Bartholomeus, S.5
Wolter, P.6
-
82
-
-
84900540918
-
A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies
-
Lin C.C., Su W.C., Yen C.J., Hsu C.H., Su W.P., Yeh K.H., et al. A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies. Br J Cancer 2014, 110(10):2434-2440.
-
(2014)
Br J Cancer
, vol.110
, Issue.10
, pp. 2434-2440
-
-
Lin, C.C.1
Su, W.C.2
Yen, C.J.3
Hsu, C.H.4
Su, W.P.5
Yeh, K.H.6
-
83
-
-
84899409111
-
An open-label, single-arm, phase 2 trial of the Polo-like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer
-
Stadler W.M., Vaughn D.J., Sonpavde G., Vogelzang N.J., Tagawa S.T., Petrylak D.P., et al. An open-label, single-arm, phase 2 trial of the Polo-like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer. Cancer 2014, 120(7):976-982.
-
(2014)
Cancer
, vol.120
, Issue.7
, pp. 976-982
-
-
Stadler, W.M.1
Vaughn, D.J.2
Sonpavde, G.3
Vogelzang, N.J.4
Tagawa, S.T.5
Petrylak, D.P.6
-
84
-
-
84874606380
-
Phase I trial of the polo-like kinase (Plk) inhibitor volasertib (BI 6727) combined with cisplatin or carboplatin in patients with advanced solid tumors
-
[abstract 3018]
-
Dumez H., Gombos A., Schoffski P., Gil T., Vulsteke C., Meeus M., et al. Phase I trial of the polo-like kinase (Plk) inhibitor volasertib (BI 6727) combined with cisplatin or carboplatin in patients with advanced solid tumors. J Clin Oncol 2012, 30. [abstract 3018].
-
(2012)
J Clin Oncol
, vol.30
-
-
Dumez, H.1
Gombos, A.2
Schoffski, P.3
Gil, T.4
Vulsteke, C.5
Meeus, M.6
-
85
-
-
84921678805
-
Human ABCB1 and ABCG2 confer acquired resistance to Polo-like kinase 1 inhibitors, BI 2536, volasertib and GSK641364
-
Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr 766 2014].
-
Wu C, Sim H, Ambudkar SV. Human ABCB1 and ABCG2 confer acquired resistance to Polo-like kinase 1 inhibitors, BI 2536, volasertib and GSK641364. In: Proceedings of the 105th annual meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr 766 2014].
-
(2014)
Proceedings of the 105th annual meeting of the American Association for Cancer Research
-
-
Wu, C.1
Sim, H.2
Ambudkar, S.V.3
-
86
-
-
84870591993
-
Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling
-
Hepburn A.C., Veeratterapillay R., Williamson S.C., El-Sherif A., Sahay N., Thomas H.D., et al. Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling. PLoS ONE 2012, 7(11):e50690.
-
(2012)
PLoS ONE
, vol.7
, Issue.11
, pp. e50690
-
-
Hepburn, A.C.1
Veeratterapillay, R.2
Williamson, S.C.3
El-Sherif, A.4
Sahay, N.5
Thomas, H.D.6
-
87
-
-
84957661117
-
A phase I dose escalation study of TKM-080301, a RNAi therapeutic directed against PLK1, in patients with advanced solid tumors
-
Apr 6-10; Washington, DC, Philadelphia (PA): AACR; 2013 [Abstract nr LB-289].
-
Ramanathan RK, Hamburg SI, Borad MJ, Seetharam M, Kundranda MN, Lee P, et al. A phase I dose escalation study of TKM-080301, a RNAi therapeutic directed against PLK1, in patients with advanced solid tumors. In: Proceedings of the 104th annual meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC, Philadelphia (PA): AACR; 2013 [Abstract nr LB-289].
-
(2013)
Proceedings of the 104th annual meeting of the American Association for Cancer Research
-
-
Ramanathan, R.K.1
Hamburg, S.I.2
Borad, M.J.3
Seetharam, M.4
Kundranda, M.N.5
Lee, P.6
-
88
-
-
84859414644
-
TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens
-
Hikichi Y., Honda K., Hikami K., Miyashita H., Kaieda I., Murai S., et al. TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. Mol Cancer Ther 2012, 11(3):700-709.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.3
, pp. 700-709
-
-
Hikichi, Y.1
Honda, K.2
Hikami, K.3
Miyashita, H.4
Kaieda, I.5
Murai, S.6
-
89
-
-
84902664257
-
RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition. Clinical cancer research: an official journal of the American Association for
-
van der Meer R., Yong Song H., Park S.H., Abdulkadir S.A., Roh M. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition. Clinical cancer research: an official journal of the American Association for. Cancer Res 2014, 20(12):3211-3221.
-
(2014)
Cancer Res
, vol.20
, Issue.12
, pp. 3211-3221
-
-
van der Meer, R.1
Yong Song, H.2
Park, S.H.3
Abdulkadir, S.A.4
Roh, M.5
-
90
-
-
60749109846
-
Cell cycle, CDKs and cancer: a changing paradigm
-
Malumbres M., Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009, 9(3):153-166.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.3
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
91
-
-
84880481139
-
CDK4: a key player in the cell cycle, development, and cancer
-
Baker S.J., Reddy E.P. CDK4: a key player in the cell cycle, development, and cancer. Genes & Cancer 2012, 3(11-12):658-669.
-
(2012)
Genes & Cancer
, vol.3
, Issue.11-12
, pp. 658-669
-
-
Baker, S.J.1
Reddy, E.P.2
-
92
-
-
70349451845
-
Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
-
Italiano A., Bianchini L., Gjernes E., Keslair F., Ranchere-Vince D., Dumollard J.M., et al. Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas. Clin Cancer Res 2009, 15(18):5696-5703.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.18
, pp. 5696-5703
-
-
Italiano, A.1
Bianchini, L.2
Gjernes, E.3
Keslair, F.4
Ranchere-Vince, D.5
Dumollard, J.M.6
-
93
-
-
84891404537
-
Expression of cyclin d1 and its association with disease characteristics in bladder cancer
-
Kopparapu P.K., Boorjian S.A., Robinson B.D., Downes M., Gudas L.J., Mongan N.P., et al. Expression of cyclin d1 and its association with disease characteristics in bladder cancer. Anticancer Res 2013, 33(12):5235-5242.
-
(2013)
Anticancer Res
, vol.33
, Issue.12
, pp. 5235-5242
-
-
Kopparapu, P.K.1
Boorjian, S.A.2
Robinson, B.D.3
Downes, M.4
Gudas, L.J.5
Mongan, N.P.6
-
94
-
-
0031054096
-
Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features
-
Lee C.C., Yamamoto S., Morimura K., Wanibuchi H., Nishisaka N., Ikemoto S., et al. Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features. Cancer 1997, 79(4):780-789.
-
(1997)
Cancer
, vol.79
, Issue.4
, pp. 780-789
-
-
Lee, C.C.1
Yamamoto, S.2
Morimura, K.3
Wanibuchi, H.4
Nishisaka, N.5
Ikemoto, S.6
-
95
-
-
84872724548
-
Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer
-
Fristrup N., Birkenkamp-Demtroder K., Reinert T., Sanchez-Carbayo M., Segersten U., Malmstrom P.U., et al. Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer. Am J Pathol 2013, 182(2):339-349.
-
(2013)
Am J Pathol
, vol.182
, Issue.2
, pp. 339-349
-
-
Fristrup, N.1
Birkenkamp-Demtroder, K.2
Reinert, T.3
Sanchez-Carbayo, M.4
Segersten, U.5
Malmstrom, P.U.6
-
96
-
-
12244264803
-
Detecting homozygous deletions in the CDKN2A(p16(INK4a))/ARF(p14(ARF)) gene in urinary bladder cancer using real-time quantitative PCR
-
Berggren P., Kumar R., Sakano S., Hemminki L., Wada T., Steineck G., et al. Detecting homozygous deletions in the CDKN2A(p16(INK4a))/ARF(p14(ARF)) gene in urinary bladder cancer using real-time quantitative PCR. Clin Cancer Res 2003, 9(1):235-242.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.1
, pp. 235-242
-
-
Berggren, P.1
Kumar, R.2
Sakano, S.3
Hemminki, L.4
Wada, T.5
Steineck, G.6
-
97
-
-
23844456592
-
Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency, a high frequency of homozygous co-deletion and associations with clinical phenotype
-
Chapman E.J., Harnden P., Chambers P., Johnston C., Knowles M.A. Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency, a high frequency of homozygous co-deletion and associations with clinical phenotype. Clin Cancer Res 2005, 11(16):5740-5747.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.16
, pp. 5740-5747
-
-
Chapman, E.J.1
Harnden, P.2
Chambers, P.3
Johnston, C.4
Knowles, M.A.5
-
98
-
-
84862012178
-
CDKN2A homozygous deletion is associated with muscle invasion in FGFR3-mutated urothelial bladder carcinoma
-
Rebouissou S., Herault A., Letouze E., Neuzillet Y., Laplanche A., Ofualuka K., et al. CDKN2A homozygous deletion is associated with muscle invasion in FGFR3-mutated urothelial bladder carcinoma. J Pathol 2012, 227(3):315-324.
-
(2012)
J Pathol
, vol.227
, Issue.3
, pp. 315-324
-
-
Rebouissou, S.1
Herault, A.2
Letouze, E.3
Neuzillet, Y.4
Laplanche, A.5
Ofualuka, K.6
-
99
-
-
84893520397
-
Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy
-
Choi W., Porten S., Kim S., Willis D., Plimack E.R., Hoffman-Censits J., et al. Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. Cancer Cell 2014, 25(2):152-165.
-
(2014)
Cancer Cell
, vol.25
, Issue.2
, pp. 152-165
-
-
Choi, W.1
Porten, S.2
Kim, S.3
Willis, D.4
Plimack, E.R.5
Hoffman-Censits, J.6
-
100
-
-
84920567742
-
Final results of a randomized Phase II study of PD 0332991, a cyclin-dependent kinase (CDK)-4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER+/HER2- advanced breast cancer (PALOMA-1; TRIO-18)
-
Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr CT101 2014].
-
Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO, et al. Final results of a randomized Phase II study of PD 0332991, a cyclin-dependent kinase (CDK)-4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER+/HER2- advanced breast cancer (PALOMA-1; TRIO-18). In: Proceedings of the 105th annual meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego Philadelphia (PA): AACR; 2014 [Abstract nr CT101 2014].
-
(2014)
Proceedings of the 105th annual meeting of the American Association for Cancer Research
-
-
Finn, R.S.1
Crown, J.P.2
Lang, I.3
Boer, K.4
Bondarenko, I.M.5
Kulyk, S.O.6
-
101
-
-
0031647626
-
Different concentrations of two small stress proteins, alphaB crystallin and HSP27 in human urological tumor tissues
-
Takashi M., Katsuno S., Sakata T., Ohshima S., Kato K. Different concentrations of two small stress proteins, alphaB crystallin and HSP27 in human urological tumor tissues. Urol Res 1998, 26(6):395-399.
-
(1998)
Urol Res
, vol.26
, Issue.6
, pp. 395-399
-
-
Takashi, M.1
Katsuno, S.2
Sakata, T.3
Ohshima, S.4
Kato, K.5
-
102
-
-
0037334496
-
Clinical significance of heat shock protein-70 expression in bladder cancer
-
Syrigos K.N., Harrington K.J., Karayiannakis A.J., Sekara E., Chatziyianni E., Syrigou E.I., et al. Clinical significance of heat shock protein-70 expression in bladder cancer. Urology 2003, 61(3):677-680.
-
(2003)
Urology
, vol.61
, Issue.3
, pp. 677-680
-
-
Syrigos, K.N.1
Harrington, K.J.2
Karayiannakis, A.J.3
Sekara, E.4
Chatziyianni, E.5
Syrigou, E.I.6
-
103
-
-
48749115689
-
Intravesically administered antisense oligonucleotides targeting heat-shock protein-27 inhibit the growth of non-muscle-invasive bladder cancer
-
Hadaschik B.A., Jackson J., Fazli L., Zoubeidi A., Burt H.M., Gleave M.E., et al. Intravesically administered antisense oligonucleotides targeting heat-shock protein-27 inhibit the growth of non-muscle-invasive bladder cancer. BJU Int 2008, 102(5):610-616.
-
(2008)
BJU Int
, vol.102
, Issue.5
, pp. 610-616
-
-
Hadaschik, B.A.1
Jackson, J.2
Fazli, L.3
Zoubeidi, A.4
Burt, H.M.5
Gleave, M.E.6
-
104
-
-
33846821658
-
Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells
-
Kamada M., So A., Muramaki M., Rocchi P., Beraldi E., Gleave M. Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells. Mol Cancer Ther 2007, 6(1):299-308.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.1
, pp. 299-308
-
-
Kamada, M.1
So, A.2
Muramaki, M.3
Rocchi, P.4
Beraldi, E.5
Gleave, M.6
-
105
-
-
68849099328
-
Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer
-
Matsui Y., Hadaschik B.A., Fazli L., Andersen R.J., Gleave M.E., So A.I. Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer. Mol Cancer Ther 2009, 8(8):2402-2411.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.8
, pp. 2402-2411
-
-
Matsui, Y.1
Hadaschik, B.A.2
Fazli, L.3
Andersen, R.J.4
Gleave, M.E.5
So, A.I.6
-
106
-
-
84879947968
-
A phase I trial of intravesical antisense oligonucleotide targeting heat shock protein 27 (OGX-427) for the treatment of non-muscle-invasive bladder cancer
-
[abstr 286]
-
So A.I., Black P.C., Chi K.N., Hurtado-Col A., Gleave M.E. A phase I trial of intravesical antisense oligonucleotide targeting heat shock protein 27 (OGX-427) for the treatment of non-muscle-invasive bladder cancer. J Clin Oncol 2012, 30(5s). [abstr 286].
-
(2012)
J Clin Oncol
, vol.30
, Issue.5 s
-
-
So, A.I.1
Black, P.C.2
Chi, K.N.3
Hurtado-Col, A.4
Gleave, M.E.5
-
107
-
-
84055190677
-
Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy
-
Yoshida S., Koga F., Tatokoro M., Kawakami S., Fujii Y., Kumagai J., et al. Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy. Cell Cycle 2011, 10(24):4291-4299.
-
(2011)
Cell Cycle
, vol.10
, Issue.24
, pp. 4291-4299
-
-
Yoshida, S.1
Koga, F.2
Tatokoro, M.3
Kawakami, S.4
Fujii, Y.5
Kumagai, J.6
-
108
-
-
77956476510
-
17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
-
Karkoulis P.K., Stravopodis D.J., Margaritis L.H., Voutsinas G.E. 17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells. BMC Cancer 2010, 10:481.
-
(2010)
BMC Cancer
, vol.10
, pp. 481
-
-
Karkoulis, P.K.1
Stravopodis, D.J.2
Margaritis, L.H.3
Voutsinas, G.E.4
-
109
-
-
84856934940
-
Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells
-
Tatokoro M., Koga F., Yoshida S., Kawakami S., Fujii Y., Neckers L., et al. Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells. Int J Cancer 2012, 131(4):987-996.
-
(2012)
Int J Cancer
, vol.131
, Issue.4
, pp. 987-996
-
-
Tatokoro, M.1
Koga, F.2
Yoshida, S.3
Kawakami, S.4
Fujii, Y.5
Neckers, L.6
-
110
-
-
84904254200
-
FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism
-
Acquaviva J., He S., Zhang C., Jimenez J.P., Nagai M., Sang J., et al. FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism. Mol Cancer Res 2014, 12(7):1042-1054.
-
(2014)
Mol Cancer Res
, vol.12
, Issue.7
, pp. 1042-1054
-
-
Acquaviva, J.1
He, S.2
Zhang, C.3
Jimenez, J.P.4
Nagai, M.5
Sang, J.6
-
111
-
-
0020030473
-
Immunological profile of patients with transitional cell carcinoma of the bladder
-
Mukamel E., Shohat B., Servadio C. Immunological profile of patients with transitional cell carcinoma of the bladder. Br J Urol 1982, 54(1):11-15.
-
(1982)
Br J Urol
, vol.54
, Issue.1
, pp. 11-15
-
-
Mukamel, E.1
Shohat, B.2
Servadio, C.3
-
112
-
-
33845311502
-
Human bladder carcinoma is dominated by T-regulatory cells and Th1 inhibitory cytokines
-
Loskog A., Ninalga C., Paul-Wetterberg G., de la Torre M., Malmstrom P.U., Totterman T.H. Human bladder carcinoma is dominated by T-regulatory cells and Th1 inhibitory cytokines. J Urol 2007, 177(1):353-358.
-
(2007)
J Urol
, vol.177
, Issue.1
, pp. 353-358
-
-
Loskog, A.1
Ninalga, C.2
Paul-Wetterberg, G.3
de la Torre, M.4
Malmstrom, P.U.5
Totterman, T.H.6
-
113
-
-
34247271873
-
CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma
-
Sharma P., Shen Y., Wen S., Yamada S., Jungbluth A.A., Gnjatic S., et al. CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc Natl Acad Sci USA 2007, 104(10):3967-3972.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.10
, pp. 3967-3972
-
-
Sharma, P.1
Shen, Y.2
Wen, S.3
Yamada, S.4
Jungbluth, A.A.5
Gnjatic, S.6
-
114
-
-
51049096135
-
T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival
-
Boorjian S.A., Sheinin Y., Crispen P.L., Farmer S.A., Lohse C.M., Kuntz S.M., et al. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin Cancer Res 2008, 14(15):4800-4808.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.15
, pp. 4800-4808
-
-
Boorjian, S.A.1
Sheinin, Y.2
Crispen, P.L.3
Farmer, S.A.4
Lohse, C.M.5
Kuntz, S.M.6
-
115
-
-
84905698694
-
Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
-
[abstr 5011]
-
Powles T., Vogelzang N.J., Fine D.G., Eder J.P., Braiteh F.S., Loriot Y., et al. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). J Clin Oncol 2014, 32(5s). [abstr 5011].
-
(2014)
J Clin Oncol
, vol.32
, Issue.5 s
-
-
Powles, T.1
Vogelzang, N.J.2
Fine, D.G.3
Eder, J.P.4
Braiteh, F.S.5
Loriot, Y.6
-
116
-
-
34247113727
-
PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression
-
Inman B.A., Sebo T.J., Frigola X., Dong H., Bergstralh E.J., Frank I., et al. PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression. Cancer 2007, 109(8):1499-1505.
-
(2007)
Cancer
, vol.109
, Issue.8
, pp. 1499-1505
-
-
Inman, B.A.1
Sebo, T.J.2
Frigola, X.3
Dong, H.4
Bergstralh, E.J.5
Frank, I.6
-
117
-
-
84890980389
-
Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer
-
Drake C.G., Lipson E.J., Brahmer J.R. Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer. Nat Rev Clin Oncol 2014, 11(1):24-37.
-
(2014)
Nat Rev Clin Oncol
, vol.11
, Issue.1
, pp. 24-37
-
-
Drake, C.G.1
Lipson, E.J.2
Brahmer, J.R.3
-
118
-
-
77949826710
-
The biologic importance of tumor-infiltrating lymphocytes
-
Hodi F.S., Dranoff G. The biologic importance of tumor-infiltrating lymphocytes. J Cutan Pathol 2010, 37(Suppl 1):48-53.
-
(2010)
J Cutan Pathol
, vol.37
, pp. 48-53
-
-
Hodi, F.S.1
Dranoff, G.2
-
119
-
-
77952337834
-
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial
-
Carthon B.C., Wolchok J.D., Yuan J., Kamat A., Ng Tang D.S., Sun J., et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res 2010, 16(10):2861-2871.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.10
, pp. 2861-2871
-
-
Carthon, B.C.1
Wolchok, J.D.2
Yuan, J.3
Kamat, A.4
Ng Tang, D.S.5
Sun, J.6
-
120
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
Curran M.A., Montalvo W., Yagita H., Allison J.P. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci USA 2010, 107(9):4275-4280.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.9
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
121
-
-
84879104519
-
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
-
Duraiswamy J., Kaluza K.M., Freeman G.J., Coukos G. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res 2013, 73(12):3591-3603.
-
(2013)
Cancer Res
, vol.73
, Issue.12
, pp. 3591-3603
-
-
Duraiswamy, J.1
Kaluza, K.M.2
Freeman, G.J.3
Coukos, G.4
-
122
-
-
84904061991
-
Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors
-
Wainwright D.A., Chang A.L., Dey M., Balyasnikova I.V., Kim C.K., Tobias A., et al. Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors. Clin Cancer Res 2014, 20(20):5290-5301.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.20
, pp. 5290-5301
-
-
Wainwright, D.A.1
Chang, A.L.2
Dey, M.3
Balyasnikova, I.V.4
Kim, C.K.5
Tobias, A.6
-
123
-
-
12144290526
-
A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity
-
Card K.F., Price-Schiavi S.A., Liu B., Thomson E., Nieves E., Belmont H., et al. A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity. Cancer Immunol Immunother 2004, 53(4):345-357.
-
(2004)
Cancer Immunol Immunother
, vol.53
, Issue.4
, pp. 345-357
-
-
Card, K.F.1
Price-Schiavi, S.A.2
Liu, B.3
Thomson, E.4
Nieves, E.5
Belmont, H.6
-
124
-
-
84055212017
-
*0201 complex, in patients with advanced malignancies
-
*0201 complex, in patients with advanced malignancies. Clin Cancer Res 2011, 17(24):7765-7775.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.24
, pp. 7765-7775
-
-
Fishman, M.N.1
Thompson, J.A.2
Pennock, G.K.3
Gonzalez, R.4
Diez, L.M.5
Daud, A.I.6
-
125
-
-
84921629730
-
Phase I/II clinical trial of ALT-801 a T-cell receptor/IL-2 fusion protein plus gemcitabine and cisplatin in urothelial cancer
-
[abstr 271]
-
Fishman M.N., Hadjenberg J., Kuzel T., Mahipal A., Rosser C.J., Landau D., et al. Phase I/II clinical trial of ALT-801 a T-cell receptor/IL-2 fusion protein plus gemcitabine and cisplatin in urothelial cancer. J Clin Oncol 2013, 31(6s). [abstr 271].
-
(2013)
J Clin Oncol
, vol.31
, Issue.6 s
-
-
Fishman, M.N.1
Hadjenberg, J.2
Kuzel, T.3
Mahipal, A.4
Rosser, C.J.5
Landau, D.6
-
126
-
-
77953701535
-
AdCD40L immunogene therapy for bladder carcinoma - the first phase I/IIa trial
-
Malmstrom P.U., Loskog A.S., Lindqvist C.A., Mangsbo S.M., Fransson M., Wanders A., et al. AdCD40L immunogene therapy for bladder carcinoma - the first phase I/IIa trial. Clin Cancer Res 2010, 16(12):3279-3287.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.12
, pp. 3279-3287
-
-
Malmstrom, P.U.1
Loskog, A.S.2
Lindqvist, C.A.3
Mangsbo, S.M.4
Fransson, M.5
Wanders, A.6
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