Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

Prostate

Volumn 60, Issue 3, 2004, Pages 240-245

  Weichert, Wilko ^a   Schmidt, Mathias ^b   Gekeler, Volker ^b   Denkert, Carsten ^a   Stephan, Carsten ^a   Jung, Klaus ^a   Loening, Stefan ^a   Dietel, Manfred ^a   Kristiansen, Glen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Immunohistochemistry; Mitosis; Polo like kinase; Prognosis; Prostate carcinoma

Indexed keywords

POLO LIKE KINASE 1; PROSTATE SPECIFIC ANTIGEN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GRADING; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MITOSIS; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROSTATE CARCINOMA;

AGED; CARCINOMA; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE-FREE SURVIVAL; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 3242792692     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.20050     Document Type: Article

References (23)

1. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2003. CA Cancer J Clin 2003;53:5-26.
2. Chakravarti A, Zhai GG. Molecular and genetic prognostic factors of prostate cancer. World J Urol 2003;9: [Epub ahead of print].
3. Sunkel CE, Glover DM. Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci 1988;89:25-38.
4. Nigg EA. Polo-like kinases: Positive regulators of cell division from start to finish. Curr Opin Cell Biol 1998;10:776-783.
5. Donaldson MM, Tavares AA, Hagan IM, Nigg EA, Glover DM. The mitotic roles of polo-like kinase. J Cell Sci 2001;114:2357-2358.
6. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science 2002;298:1912-1934.
7. Tokumitsu Y, Mori M, Tanaka S, Akazawa K, Nakano S, Niho Y. Prognostic significance of polo-like kinase expression in esophageal carcinoma. Int J Oncol 1999;15:687-692.
8. Wolf G, Elez R, Doermer A, Holtrich U, Ackermann H, Stutte HJ, Altmannsberger HM, Rubsamen-Waigmann H, Strebhardt K. Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer. Oncogene 1997;14:543-549.
9. Kneisel L, Strebhardt K, Bernd A, Wolter M, Binder A, Kaufmann R. Expression of polo-like kinase (PLK1) in thin melanomas: A novel marker of metastatic disease. J Cutan Pathol 2002;29:354-358.
10. Knecht R, Elez R, Oechler M, Solbach C, von Ilberg C, Strebhardt K. Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res 1999;59:2794-2797.
11. Dietzmann K, Kirches E, von Bossanyi, Jachau K, Mawrin C. Increased human polo-like kinase-1 expression in gliomas. J Neurooncol 2001;53:1-11.
12. Takahashi T, Sano B, Nagata T, Kato H,Sugiyama Y, Kunieda K, Kimura M, Okano Y, Saji S. Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers. Cancer Sci 2003;94:148-152.
13. Wolf G, Hildenbrand R, Schwar C, Grobholz R, Kaufmann M, Stutte HJ, Strebhardt K, Bleyl U. Polo-like kinase: A novel marker of proliferation: Correlation with estrogen-receptor expression in human breast cancer. Pathol Res Pract 2000;196:753-759.
14. Takai N, Miyazaki T, Fujisawa K, Nasu K, Hamanaka R, Miyakawa I. Polo-like kinase (PLK) expression in endometrial carcinoma. Cancer Lett 2001;169:41-49.
15. Takai N, Miyazaki T, Fujisawa K, Nasu K, Hamanaka R, Miyakawa I. Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage. Cancer Lett 2001;164:41-49.
16. Elez R, Piiper A, Kronenberger B, Kock M, Brendel M, Hermann E, Pliquett U, Neumann E, Zeuzem S. Tumor regression by combination antisense therapy against Plk1 and Bcl-2. Oncogene 2003;22:69-80.
17. Toyoshima-Morimoto F, Taniguchi E, Nishida E. Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep 2002;3:341-348.
18. Yuan J, Eckerdt F, Bereiter-Hahn J, Kurunci-Csacsko E, Kaufmann M, Strebhardt K. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. Oncogene 2002;21:8282-8292.
19. Golan A, Yudkovsky Y, Hershko A. The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J Biol Chem 2002;277:15552-15557.
20. Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM. The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase. Mol Cell 2002;9:515-525.
21. Spänkuch-Schmitt B, Wolf G, Solbach C, Loibl S, Knecht R, Stegmüller M, von Minckwitz G, Kaufmann M, Strebhardt K. Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells. Oncogene 2002;21:3162-3171.
22. Spänkuch-Schmitt B, Bereiter-Hahn J, Kaufmann M, Strebhardt K. Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells. J Natl Cancer Inst 2002;94:1863-1877.
23. Liu X, Erikson RL. Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci USA 2003;100:5789-5794.