Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes

Journal of Molecular and Cellular Cardiology

Volumn 80, Issue , 2015, Pages 126-135

  Chan, Yi Hsin ^a,b   Tsai, Wei Chung ^a,c   Song, Zhen ^d   Ko, Christopher Y ^d   Qu, Zhilin ^d   Weiss, James N ^d   Lin, Shien Fong ^a,e   Chen, Peng Sheng ^a   Jones, Larry R ^a   Chen, Zhenhui ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

Calcium; Phospholamban; Sarcoplasmic reticulum; Spontaneous calcium waves

Indexed keywords

CALCIUM ION; FLUORESCENT DYE; FLUORESCENT DYE FLUO 4; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2D12; PHOSPHOLAMBAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; CALCIUM; CALCIUM BINDING PROTEIN; CYCLIC AMP;

ADULT; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL ISOLATION; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; FREQUENCY MODULATION; HEART MUSCLE CELL; HEART RHYTHM; HEART VENTRICLE; MOLECULAR DYNAMICS; MOUSE; NEUROMUSCULAR FACILITATION; NONHUMAN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPATIOTEMPORAL ANALYSIS; WHOLE CELL PATCH CLAMP; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; SARCOPLASMIC RETICULUM;

ANIMALS; ANTIBODIES, MONOCLONAL; CALCIUM; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; COMPUTER SIMULATION; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 84921645446     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.12.024     Document Type: Article

References (42)

1. Simmerman H.K., Jones L.R. Phospholamban: protein structure, mechanism of action, and role in cardiac function. Physiol Rev 1998, 78:921-947.
2. Kranias E.G., Hajjar R.J. Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circ Res 2012, 110:1646-1660.
3. 2+-ATPase activity in guinea pig ventricles. J Biol Chem 1983, 258:464-471.
4. Brittsan A.G., Kranias E.G. Phospholamban and cardiac contractile function. J Mol Cell Cardiol 2000, 32:2131-2139.
5. 2+ uptake in mammalian ventricular myocytes. Am J Physiol 1991, 261:H1344-H1349.
6. Mattiazzi A., Hove-Madsen L., Bers D.M. Protein kinase inhibitors reduce SR Ca transport in permeabilized cardiac myocytes. Am J Physiol 1994, 267:H812-H820.
7. Luo W., Grupp I.L., Harrer J., Ponniah S., Grupp G., Duffy J.J., et al. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res 1994, 75:401-409.
8. Santana L.F., Kranias E.G., Lederer W.J. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. J Physiol 1997, 503(Pt 1):21-29.
9. 2+. Am J Physiol 1996, 271:C391-C397.
10. Koss K.L., Kranias E.G. Phospholamban: a prominent regulator of myocardial contractility. Circ Res 1996, 79:1059-1063.
11. Eisner D.A., Kashimura T., O'Neill S.C., Venetucci L.A., Trafford A.W. What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?. J Mol Cell Cardiol 2009, 46:474-481.
12. 2+ handling and arrhythmogenesis. Circ Res 2011, 108:871-883.
13. Bers D.M. Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction. Annu Rev Physiol 2014, 76:107-127.
14. 2+-triggered arrhythmias. Nat Med 2014, 20:184-192.
15. Marx S.O., Reiken S., Hisamatsu Y., Jayaraman T., Burkhoff D., Rosemblit N., et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 2000, 101:365-376.
16. Li Y., Kranias E.G., Mignery G.A., Bers D.M. Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res 2002, 90:309-316.
17. 2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res 2006, 99:398-406.
18. Gyorke I., Hester N., Jones L.R., Gyorke S. The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Biophys J 2004, 86:2121-2128.
19. 2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest 2006, 116:2510-2520.
20. Chu G., Luo W., Slack J.P., Tilgmann C., Sweet W.E., Spindler M., et al. Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts. Circ Res 1996, 79:1064-1076.
21. 2+ uptake to improve heart failure: hit or miss. Circ Res 2010, 106:230-233.
22. 2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res 2010, 106:659-673.
23. Kapoor N., Liang W., Marban E., Cho H.C. Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol 2013, 31:54-62.
24. 2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design. J Mol Cell Cardiol 2014, 66:106-115.
25. 2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circ Res 2013, 113:517-526.
26. 2+-ATPase by protein kinase A and by anti-phospholamban monoclonal antibody 2D12. J Biol Chem 2007, 282:20968-20976.
27. Nivala M., Ko C.Y., Nivala M., Weiss J.N., Qu Z. Criticality in intracellular calcium signaling in cardiac myocytes. Biophys J 2012, 102:2433-2442.
28. Nivala M., Ko C.Y., Nivala M., Weiss J.N., Qu Z. The emergence of subcellular pacemaker sites for calcium waves and oscillations. J Physiol 2013, 591:5305-5320.
29. Picht E., Zima A.V., Blatter L.A., Bers D.M. SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol 2007, 293:C1073-C1081.
30. Restrepo J.G., Weiss J.N., Karma A. Calsequestrin-mediated mechanism for cellular calcium transient alternans. Biophys J 2008, 95:3767-3789.
31. Nivala M., de Lange E., Rovetti R., Qu Z. Computational modeling and numerical methods for spatiotemporal calcium cycling in ventricular myocytes. Front Physiol 2012, 3:114.
32. Wegener A.D., Simmerman H.K., Lindemann J.P., Jones L.R. Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation. J Biol Chem 1989, 264:11468-11474.
33. 2+-ATPase 2a (SERCA2a) protein binding interactions in human cardiac sarcoplasmic reticulum vesicles using chemical cross-linking. J Biol Chem 2012, 287:7582-7593.
34. 2+ waves in saponin-permeabilized rat ventricular myocytes. J Physiol 1999, 521(Pt 3):575-585.
35. Lukyanenko V. Permeabilization of cell membrane for delivery of nano-objects to cellular sub-domains. Methods Mol Biol 2013, 991:57-63.
36. Jamur M.C., Oliver C. Permeabilization of cell membranes. Methods Mol Biol 2010, 588:63-66.
37. Keller M., Kao J.P., Egger M., Niggli E. Calcium waves driven by "sensitization" wave-fronts. Cardiovasc Res 2007, 74:39-45.
38. Hoit B.D., Khoury S.F., Kranias E.G., Ball N., Walsh R.A. In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency. Circ Res 1995, 77:632-637.
39. DeSantiago J., Maier L.S., Bers D.M. Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol 2002, 34:975-984.
40. i transients in phospholamban-deficient mouse ventricular cells. Am J Physiol 1998, 274:H1800-H1811.
41. 2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span. J Mol Cell Cardiol 2006, 41:308-317.
42. 2+-dependent hypertrophic signaling. Am J Physiol Heart Circ Physiol 2012, 302:H2574-H2582.