Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells

Marine Drugs

Volumn 13, Issue 1, 2015, Pages 543-557

  Lee, Hyun Young ^a   Chung, Kyu Jin ^b   Hwang, In Hyun ^c   Gwak, Jungsuk ^d   Park, Seoyoung ^a   Ju, Bong Gun ^d   Yun, Eunju ^b   Kim, Dong Eun ^e   Chung, Young Hwa ^f   Na, MinKyun ^b   Song, Gyu Yong ^b   Oh, Sangtaek ^a  

^a Kookmin University   (South Korea)

^b Chungnam National University   (South Korea)

^c University of Iowa   (United States)

^d Sogang University   (South Korea)

^e Konkuk University   (South Korea)

^f Pusan National University   (South Korea)

Author keywords

Apoptosis; Autophagy; Colon cancer; Ethylsmenoquinone; Ilimaquinone; P53

Indexed keywords

ETHYLSMENOQUINONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; ILIMAQUINONE; MICROTUBULE ASSOCIATED PROTEIN 1; PROTEIN P53; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; SESQUITERPENE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CATALYSIS; CELL CYCLE ARREST; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVATION; HIPPOSPONGIA METACHROMIA; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN METABOLISM; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPONGE (PORIFERA); TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING; CELL CYCLE G2 PHASE; COLONIC NEOPLASMS; DRUG EFFECTS; HCT116 CELL LINE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BENZOQUINONES; CELL LINE, TUMOR; COLONIC NEOPLASMS; G2 PHASE; HCT116 CELLS; HUMANS; QUINONES; SESQUITERPENES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84921642421     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13010543     Document Type: Article

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