Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage

Iranian Journal of Basic Medical Sciences

Volumn 17, Issue 12, 2014, Pages 986-992

  Havakhah, Shahrzad ^a   Sadeghnia, Hamid R ^b   Hajzadeh, Mosa Al Reza ^a   Roshan, Nama Mohammadian ^c   Shafiee, Somayeh ^a   Hosseinzadeh, Hossein ^d   Mohareri, Narges ^e   Rad, Abolfazl Khajavi ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Comet assay; Ischemia reperfusion injury (IRI); Kidney; Nigella sativa; Oxidative stress

Indexed keywords

ALCOHOL; MALONALDEHYDE; NIGELLA SATIVA EXTRACT; THIOL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLACK CUMIN; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DRUG DOSE COMPARISON; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NONHUMAN; PLANT SEED; RAT; REPERFUSION INJURY; SCORING SYSTEM;

NIGELLA SATIVA; RATTUS;

EID: 84921634815     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011; 121:4210-4221.
2. Wachtel-Galor S, Benzie IFF. Herbal medicine: An introduction to Its history, usage, regulation, current trends, and research needs. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL): CRC Press; 2011.
3. Randhawa MA, Alghamdi MS. Anticancer activity of Nigella sativa (black seed) - a review. Am J Chin Med 2011; 39:1075-1091.
4. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005; 5:1749-1770.
5. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995; 61:33-36.
6. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res 2000; 14:323-328.
7. Ait Mbarek L, Ait Mouse H, Elabbadi N, Bensalah M, Gamouh A, Aboufatima R, et al. Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Braz J Med Biol Res 2007; 40:839-847.
8. el Tahir KE, Ashour MM, al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993; 24:1123-1131.
9. Yildiz F, Coban S, Terzi A, Savas M, Bitiren M, Celik H, et al. Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys. Ren Fail 2010; 32:126-131.
10. Hadjzadeh MA, Khoei A, Hadjzadeh Z, Parizady M. Ethanolic extract of Nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats. Urology J 2007; 4:86-90.
11. Hosseinzadeh H, Montahaei R. Protective effect of Nigella sativa L. extracts and thymoquinone, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. Pharmacologyonline 2007; 1:176-189.
12. Bayrak O, Bavbek N, Karatas OF, Bayrak R, Catal F, Cimentepe E, et al. Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys. Nephrol Dial Transplant 2008; 23:2206-2212.
13. Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol 2007; 18:1218-1226.
14. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52:302-310.
15. Sadeghnia HR, Kamkar M, Assadpour E, Boroushaki MT, Ghorbani A. Protective effect of safranal, a constituent of crocus sativus, on quinolinic acid-induced oxidative damage in rat hippocampus. Iran J Basic Med Sci 2013; 16:73-82.
16. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82:70-77.
17. Hosseinzadeh H, Abootorabi A, Sadeghnia HR. Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate-induced DNA damage in mice organs. DNA Cell Biol. 2008; 27:657-664.
18. Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 2006; 17:1503-1520.
19. Ahmadiasl N, Banaei S, Alihemmati A. Combination antioxidant effect of erythropoietin and melatonin on renal ischemia-reperfusion injury in rats. Iran J Basic Med Sci 2013; 16:1209-1216.
20. Prakash M, Shetty MS, Tilak P, Anwar N. Total thiols: Biomedical importance and their alteration in various disorders. Online J Health Allied Scs 2009; 8:2.
21. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci 2005; 8:387-393.
22. Simon F, Scheuerle A, Groger M, Stahl B, Wachter U, Vogt J, et al. Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injury. Shock 2011; 35:156-163.
23. Seif AA. Nigella sativa attenuates myocardial ischemic reperfusion injury in rats. J Physiol Biochem 2013; 69:937-944.
24. Hobbenaghi R, Javanbakht J, Sadeghzadeh S, Kheradmand D, Abdi FS, Jaberi MH, et al. Neuroprotective effects of Nigella sativa extract on cell death in hippocampal neurons following experimental global cerebral ischemia-reperfusion injury in rats. J Neurol Sci 2014; 337:74-79.
25. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 2007; 14:621-627.
26. Mousavi SH, Tayarani-Najaran Z, Asghari M, Sadeghnia HR. Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death. Cell Mol Neurobiol 2010; 30:591-598.
27. Akhtar M, Maikiyo AM, Najmi AK, Khanam R, Mujeeb M, Aqil M. Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat. J Pharm Bioallied Sci 2013; 5:119-125.
28. Akhtar M, Maikiyo AM, Khanam R, Mujeeb M, Aqil M, Najmi AK. Ameliorating effects of two extracts of Nigella sativa in middle cerebral artery occluded rat. J Pharm Bioallied Sci 2012; 4:70-75.
29. El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol 2003; 84:251-258.
30. Yildiz F, Coban S, Terzi A, Ates M, Aksoy N, Cakir H, et al. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World J Gastroenterol 2008; 14:5204-5209.
31. Bayir Y, Karagoz Y, Karakus E, Albayrak A, Sengul O, Can I, et al. Nigella sativa reduces tissue damage in rat ovaries subjected to torsion and detorsion: oxidative stress, proinflammatory response and histopathological evaluation. Gynecol Obstet Invest 2012; 74:41-49.
32. Entok E, Ustuner MC, Ozbayer C, Tekin N, Akyuz F, Yangi B, et al. Anti-inflammatuar and anti-oxidative effects of Nigella sativa L.: 18FDG-PET imaging of inflammation. Mol Biol Rep 2014; 41:2827-2834.
33. Bonventre JV, Weinberg JM. Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 2003; 14:2199-2210.
34. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P. Differential gene expression following early renal ischemia/reperfusion. Kidney Int 2003; 63:1714-1724.