Inhibition of CYP4A reduces hepatic endoplasmic reticulum stress and features of diabetes in mice

Gastroenterology

Volumn 147, Issue 4, 2014, Pages 860-869

  Park, Edmond Changkyun ^a   Kim, Seung Il ^a   Hong, Yeonhee ^a   Hwang, Jeong Won ^a   Cho, Gun Sik ^b   Cha, Hye Na ^c   Han, Jin Kwan ^b   Yun, Chul Ho ^d   Park, So Young ^c   Jang, Ik Soon ^a   Lee, Zee Won ^a   Choi, Jong Soon ^a,e   Kim, Soohyun ^f   Kim, Gun Hwa ^a,g  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Yeungnam University College of Medicine   (South Korea)

^d Chonnam National University   (South Korea)

^e Chungnam National University   (South Korea)

^f Biofabula   (South Korea)

^g University of Science and Technology (UST)   (South Korea)

Author keywords

Analysis; Model; Mouse; Obesity; Proteomic; UPR

Indexed keywords

ACYL COENZYME A DESATURASE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 4A; DIACYLGLYCEROL ACYLTRANSFERASE 2; FATTY ACID SYNTHASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRIACYLGLYCEROL; AMIDINE; ENZYME INHIBITOR; GLUCOSE BLOOD LEVEL; MESSENGER RNA; N-HYDROXY-N'-(4-BUTYL-2-METHYLPHENYL)FORMAMIDINE; SMALL INTERFERING RNA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY LIVER; GENE FUNCTION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERINSULINEMIA; IN VITRO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOPROTEIN BLOOD LEVEL; LIVER; LIVER FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; ENZYME INDUCTION; ENZYMOLOGY; GENETICS; LIPID DIET; MALE; METABOLISM; PROCEDURES; PROTEOMICS; RNA INTERFERENCE; TIME;

AMIDINES; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CYTOCHROME P-450 CYP4A; DIABETES MELLITUS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME INDUCTION; ENZYME INHIBITORS; HEP G2 CELLS; HUMANS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; PROTEOMICS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS;

EID: 84921626636     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.06.039     Document Type: Article

References (40)

1. N. Unwin, D. Gan, and D. Whiting The IDF diabetes atlas: providing evidence, raising awareness and promoting action Diabetes Res Clin Pract 87 2010 2 3
2. J.E. Shaw, R.A. Sicree, and P.Z. Zimmet Global estimates of the prevalence of diabetes for 2010 and 2030 Diabetes Res Clin Pract 87 2010 4 14
3. U. Ozcan, Q. Cao, and E. Yilmaz Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
4. Y. Nakatani, H. Kaneto, and D. Kawamori Involvement of endoplasmic reticulum stress in insulin resistance and diabetes J Biol Chem 280 2005 847 851
5. D. Ron, and P. Walter Signal integration in the endoplasmic reticulum unfolded protein response Nat Rev Mol Cell Biol 8 2007 519 529
6. C.J. van der Kallen, M.M. van Greevenbroek, and C.D. Stehouwer Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? Apoptosis 14 2009 1424 1434
7. D.L. Eizirik, A.K. Cardozo, and M. Cnop The role for endoplasmic reticulum stress in diabetes mellitus Endocr Rev 29 2008 42 61
8. C. Ioannides Cytochromes P450: role in the metabolism and toxicity of drugs and other xenobiotics 2008 Royal Society of Chemistry Cambridge
9. J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 2004 147 152
10. T.M. Leung, and N. Nieto CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease J Hepatol 58 2013 395 398
11. I.A. Leclercq, G.C. Farrell, and J. Field CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis J Clin Invest 105 2000 1067 1075
12. A. Dey, and A.I. Cederbaum Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice Hepatology 45 2007 1355 1365
13. M.D. Lewis, and B.J. Roberts Role of CYP2E1 activity in endoplasmic reticulum ubiquitination, proteasome association, and the unfolded protein response Arch Biochem Biophys 436 2005 237 245
14. A. Dey, I.G. Kessova, and A.I. Cederbaum Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1 Arch Biochem Biophys 447 2006 155 166
15. H.R. Kim, G.H. Lee, and E.Y. Cho Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1 J Cell Sci 122 2009 1126 1133
16. A.A. Eid, Y. Gorin, and B.M. Fagg Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases Diabetes 58 2009 1201 1211
17. A.L. Roe, G. Howard, and R. Blouin Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice Int J Obes Relat Metab Disord 23 1999 48 53
18. T. Sakuma, R. Honma, and S. Maguchi Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat Xenobiotica 31 2001 223 237
19. S.N. Hart, and X.B. Zhong P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity Expert Opin Drug Metab Toxicol 4 2008 439 452
20. N. Miyata, K. Taniguchi, and T. Seki HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme Br J Pharmacol 133 2001 325 329
21. M. Jiang, A. Mezentsev, and R. Kemp Smooth muscle-specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels Circ Res 94 2004 167 174
22. R.L. Smathers, J.J. Galligan, and B.J. Stewart Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease Chem Biol Interact 192 2011 107 112
23. M. Sanson, N. Auge, and C. Vindis Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression Circ Res 104 2009 328 336
24. S. Basseri, and R.C. Austin ER stress and lipogenesis: a slippery slope toward hepatic steatosis Dev Cell 15 2008 795 796
25. M.M. Kesavulu, R. Giri, and B. Kameswara Rao Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications Diabetes Metab 26 2000 387 392
26. E. Szegezdi, S.E. Logue, and A.M. Gorman Mediators of endoplasmic reticulum stress-induced apoptosis EMBO Rep 7 2006 880 885
27. H. Kaneto, Y. Nakatani, and D. Kawamori Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance Int J Biochem Cell Biol 37 2005 1595 1608
28. P.J. Van Ess, S. Poloyac, and M.P. Mattson Blunted induction of hepatic CYP4A in TNF (p55-/-/p75-/-) double receptor knockout mice following clofibrate treatment Pharm Res 19 2002 708 712
29. E. Hu, P. Liang, and B.M. Spiegelman AdipoQ is a novel adipose-specific gene dysregulated in obesity J Biol Chem 271 1996 10697 10703
30. Y. Arita, S. Kihara, and N. Ouchi Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 1999 79 83
31. K. Nakajima, K. Yamauchi, and S. Shigematsu Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells J Biol Chem 275 2000 20880 20886
32. K. Chandrasekaran, K. Swaminathan, and S. Chatterjee Apoptosis in HepG2 cells exposed to high glucose Toxicol In Vitro 24 2010 387 396
33. W. McDowell, and R.T. Schwarz Dissecting glycoprotein biosynthesis by the use of specific inhibitors Biochimie 70 1988 1535 1549
34. G.A. Davidson, and R.J. Varhol Kinetics of thapsigargin-Ca(2+)-ATPase (sarcoplasmic reticulum) interaction reveals a two-step binding mechanism and picomolar inhibition J Biol Chem 270 1995 11731 11734
35. M. Treiman, C. Caspersen, and S.B. Christensen A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases Trends Pharmacol Sci 19 1998 131 135
36. M.A. Abdelmegeed, A. Banerjee, and S.H. Yoo Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis J Hepatol 57 2012 860 866
37. J.P. Hardwick Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases Biochem Pharmacol 75 2008 2263 2275
38. S. Fu, L. Yang, and P. Li Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity Nature 473 2011 528 531
39. L. Dara, C. Ji, and N. Kaplowitz The contribution of endoplasmic reticulum stress to liver diseases Hepatology 53 2011 1752 1763
40. J.H. Lin, H. Li, and D. Yasumura IRE1 signaling affects cell fate during the unfolded protein response Science 318 2007 944 949