Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells

Cancer Letters

Volumn 358, Issue 2, 2015, Pages 170-179

  Wang, Yujun ^a   Han, Ernest ^a   Xing, Quanhua ^a   Yan, Jin ^a   Arrington, Amanda ^a   Wang, Charles ^a   Tully, Dylan ^a   Kowolik, Claudia M ^a   Lu, David M ^a   Frankel, Paul H ^a   Zhai, Jing ^a   Wen, Wei ^a   Horne, David ^a   Yip, M L Richard ^a,b   Yim, John H ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Baicalein; Cellular stress; DDIT4; IRF1; MTOR

Indexed keywords

BAICALEIN; CARBOPLATIN; CYTOPLASM PROTEIN; DNA DAMAGE INDUCIBLE TRANSCRIPT 4; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PLATINUM; PROTEIN P53; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DDIT4 PROTEIN, HUMAN; FLAVANONE DERIVATIVE; PROTEIN KINASE INHIBITOR; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL LINE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MDA468 CELL LINE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; TIME; TUMOR CELL LINE; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; FLAVANONES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEOPLASMS; PROTEIN KINASE INHIBITORS; TIME FACTORS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84921614080     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.12.033     Document Type: Article

References (27)

1. Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat. Rev 2009, 35:57-68.
2. Chen H., Gao Y., Wu J., Chen Y., Chen B., Hu J., et al. Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies. Cancer Lett 2014.
3. Fujita M., Shiota S., Kuroda T., Hatano T., Yoshida T., Mizushima T., et al. Remarkable synergies between baicalein and tetracycline, and baicalein and beta-lactams against methicillin-resistant Staphylococcus aureus. Microbiol. Immunol 2005, 49:391-396.
4. Deng G., Kurtz R.C., Vickers A., Lau N., Yeung K.S., Shia J., et al. A single arm phase II study of a Far-Eastern traditional herbal formulation (sho-sai-ko-to or xiao-chai-hu-tang) in chronic hepatitis C patients. J. Ethnopharmacol 2011, 136:83-87.
5. Kummar S., Copur M.S., Rose M., Wadler S., Stephenson J., O'Rourke M., et al. A phase I study of the Chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer. Clin. Colorectal Cancer 2011, 10:85-96.
6. Ding X.Z., Kuszynski C.A., El-Metwally T.H., Adrian T.E. Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells. Biochem. Biophys. Res. Commun 1999, 266:392-399.
7. Tong W.G., Ding X.Z., Witt R.C., Adrian T.E. Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. Mol. Cancer Ther 2002, 1:929-935.
8. Sekiya K., Okuda H. Selective inhibition of platelet lipoxygenase by baicalein. Biochem. Biophys. Res. Commun 1982, 105:1090-1095.
9. Shieh D.E., Liu L.T., Lin C.C. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res 2000, 20:2861-2865.
10. Hsu S.L., Hsieh Y.C., Hsieh W.C., Chou C.J. Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur. J. Pharmacol 2001, 425:165-171.
11. Chen K., Zhang S., Ji Y., Li J., An P., Ren H., et al. Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway. PLoS ONE 2013, 8:e72927.
12. Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K., et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol. Cell 2002, 10:995-1005.
13. Whitney M.L., Jefferson L.S., Kimball S.R., Savitsky D., Tamura T., Yanai H., et al. ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem. Biophys. Res. Commun 2009, 379:451-455.
14. Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E., et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004, 18:2893-2904.
15. Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
16. Gao J., Wang Y., Xing Q., Yan J., Senthil M., Akmal Y., et al. Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression. Mol. Cancer Ther 2011, 10:1774-1783.
17. Pizzoferrato E., Liu Y., Gambotto A., Armstrong M.J., Stang M.T., Gooding W.E., et al. Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of surviving. Cancer Res 2004, 64:8381-8388.
18. Gao J., Senthil M., Ren B., Yan J., Xing Q., Yu J., et al. IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells. Cell Death Differ 2010, 17:699-709.
19. Yu J., Wang Z., Kinzler K.W., Vogelstein B., Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:1931-1936.
20. Schmidt W., Chaney S.G. Role of carrier ligand in platinum resistance of human carcinoma cell lines. Cancer Res 1993, 53:799-805.
21. Vadysirisack D.D., Baenke F., Ory B., Lei K., Ellisen L.W. Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response. Mol. Cell. Biol 2011, 31:4356-4365.
22. Xu X., Wang H.J., Murphy P.A., Cook L., Hendrich S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J. Nutr 1994, 124:825-832.
23. Ben Sahra I., Regazzetti C., Robert G., Laurent K., Le Marchand-Brustel Y., Auberger P., et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res 2011, 71:4366-4372.
24. Fox J.T., Sakamuru S., Huang R., Teneva N., Simmons S.O., Xia M., et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:5423-5428.
25. Pamment J., Ramsay E., Kelleher M., Dornan D., Ball K.L. Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. Oncogene 2002, 21:7776-7785.
26. Taniguchi H., Yoshida T., Horinaka M., Yasuda T., Goda A.E., Konishi M., et al. Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. Cancer Res 2008, 68:8918-8927.
27. Aryal P., Kim K., Park P.H., Ham S., Cho J., Song K. Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells. FEBS J. 2014, Epub ahead of print.