Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells

FEBS Journal

Volumn 281, Issue 20, 2014, Pages 4644-4658

  Aryal, Pramod ^a   Kim, Kijoong ^a   Park, Pil Hoon ^b   Ham, Seongho ^c   Cho, Junghee ^c   Song, Kyung ^a  

^a Wonkwang University   (South Korea)

^b Yeungnam University   (South Korea)

^c Jeollanamdo Development Institute of Traditional Korean Medicine   (South Korea)

Author keywords

AMPK; Autophagy; Baicalein; MTORC1; ULK1

Indexed keywords

AMP ACTIVATED PROTEIN KINASE ALPHA; AUTOPHAGY PROTEIN 5; AUTOPHAGY RELATED PROTEIN 7; BAICALEIN; BECLIN 1; CELL PROTEIN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GREEN FLUORESCENT PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; SERINE; SMALL INTERFERING RNA; TUMOR PROTEIN; UNC 51 LIKE KINASE 1; UNCLASSIFIED DRUG; AMP-ACTIVATED PROTEIN KINASE KINASE; ANTIOXIDANT; FLAVANONE DERIVATIVE; LUCIFERASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE; ULK1 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST CANCER CELL LINE; CAENORHABDITIS ELEGANS; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL DEATH; CELL POPULATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; ENZYME ACTIVATION; ENZYME MECHANISM; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; BREAST NEOPLASMS; CELL CYCLE CHECKPOINT; DRUG EFFECTS; FEMALE; FLOW CYTOMETRY; GENETICS; MALE; METABOLISM; PATHOLOGY; PHAGOSOME; PHOSPHORYLATION; PROSTATIC NEOPLASMS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CAENORHABDITIS ELEGANS; MAMMALIA; RAPTORES;

ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; FEMALE; FLAVANONES; FLOW CYTOMETRY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MULTIPROTEIN COMPLEXES; PHAGOSOMES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOR SERINE-THREONINE KINASES;

EID: 84915774505     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12969     Document Type: Article

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