Hyperactivation of BDNF-TrkB signaling cascades in human hypothalamic hamartoma (HH): A potential mechanism contributing to epileptogenesis

CNS Neuroscience and Therapeutics

Volumn 21, Issue 2, 2015, Pages 164-172

  Semaan, Suzan ^a   Wu, Jie ^b   Gan, Yan ^a   Jin, Yu ^b   Li, Guo Hui ^b   Kerrigan, John F ^c   Chang, Yong Chang ^b   Huang, Yao ^a  

^a ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

^b BARROW NEUROLOGICAL INSTITUTE   (United States)

^c PHOENIX CHILDREN'S HOSPITAL   (United States)

Author keywords

Brain derived neurotrophic factor; Epileptogenesis; Human hypothalamic hamartoma; Signal transduction; Tropomysin related kinase B

Indexed keywords

4 AMINOBUTYRIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C GAMMA1; POTASSIUM CHLORIDE COTRANSPORTER 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TYROSINE; CARBAZOLE DERIVATIVE; COTRANSPORTER; ENZYME INHIBITOR; INDOLE ALKALOID; MEMBRANE PROTEIN; POTASSIUM-CHLORIDE SYMPORTERS; PROTEIN TYROSINE KINASE; STAUROSPORINE AGLYCONE; TROPOMYOSIN-RELATED KINASE-B, HUMAN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLOGY; DENSITOMETRY; DOWN REGULATION; ELECTROPHYSIOLOGY; EPILEPTOGENESIS; EXCITATION; FEMALE; GELASTIC SEIZURE; HAMARTOMA; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; HYPOTHALAMUS HAMARTOMA; INFANT; MALE; METHODOLOGY; MOLECULAR BIOLOGY; NEUROTRANSMISSION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; DRUG EFFECTS; GENETICS; HYPOTHALAMUS DISEASE; IN VITRO STUDY; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PATCH CLAMP TECHNIQUE; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PRESCHOOL CHILD; YOUNG ADULT;

ADOLESCENT; ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; CHILD; CHILD, PRESCHOOL; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; HAMARTOMA; HUMANS; HYPOTHALAMIC DISEASES; HYPOTHALAMUS; IN VITRO TECHNIQUES; INDOLE ALKALOIDS; INFANT; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SYMPORTERS; TYROSINE; YOUNG ADULT;

EID: 84921540430     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12331     Document Type: Article

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