Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context

Journal of Immunology

Volumn 194, Issue 3, 2015, Pages 999-1010

  Baeyens, Audrey ^b   Saadoun, David ^b   Billiard, Fabienne ^b   Rouers, Angéline ^b   Grégoire, Sylvie ^b   Zaragoza, Bruno ^b   Grinberg Bleyer, Yenkel ^b   Marodon, Gilles ^b   Piaggio, Eliane ^b   Salomon, Benoît L ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b Assistance publique Hôpitaux de Paris

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; HERMES ANTIGEN; INFLUENZA VIRUS HEMAGGLUTININ; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; L SELECTIN; OX40 LIGAND; STAT5 PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 2; PROTEIN BINDING;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; FEEDBACK SYSTEM; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PLASMACYTOID DENDRITIC CELL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; CELL COMMUNICATION; DENDRITIC CELL; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPH NODE; LYMPHOCYTE ACTIVATION; METABOLISM; PHENOTYPE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; CELL COMMUNICATION; DENDRITIC CELLS; IMMUNOPHENOTYPING; INFLAMMATION; INTERLEUKIN-2; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; OX40 LIGAND; PHENOTYPE; PROTEIN BINDING; RECEPTORS, OX40; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TUMOR NECROSIS FACTORS;

EID: 84921533473     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400504     Document Type: Article

References (49)

1. Billiard, F., E. Litvinova, D. Saadoun, F. Djelti, D. Klatzmann, J. L. Cohen, G. Marodon, and B. L. Salomon. 2006. Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation. J. Immunol. 177: 2167-2174.
2. Shevach, E. M. 2011. Biological functions of regulatory T cells. Adv. Immunol. 112: 137-176.
3. + regulatory T cells. Nat. Rev. Immunol. 11: 119-130.
4. + regulatory T cells: differentiation, specification, subphenotypes. Nat. Immunol. 10: 689-695.
5. Josefowicz, S. Z., L. F. Lu, and A. Y. Rudensky. 2012. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30: 531-564.
6. + regulatory T cells is indexed to the number of IL-2-producing cells. J. Immunol. 177: 192-200.
7. Grinberg-Bleyer, Y., D. Saadoun, A. Baeyens, F. Billiard, J. D. Goldstein, S. Grégoire, G. H. Martin, R. Elhage, N. Derian, W. Carpentier, et al. 2010. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs. J. Clin. Invest. 120: 4558-4568.
8. O'Gorman, W. E., H. Dooms, S. H. Thorne, W. F. Kuswanto, E. F. Simonds, P. O. Krutzik, G. P. Nolan, and A. K. Abbas. 2009. The initial phase of an immune response functions to activate regulatory T cells. J. Immunol. 183: 332-339.
9. Cheng, G., A. Yu, and T. R. Malek. 2011. T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol. Rev. 241: 63-76.
10. + T cells. Eur. J. Immunol. 22: 1013-1022.
11. Scott, B., R. Liblau, S. Degermann, L. A. Marconi, L. Ogata, A. J. Caton, H. O. McDevitt, and D. Lo. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1: 73-83.
12. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180: 25-34.
13. Schorle, H., T. Holtschke, T. Hünig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-624.
14. + immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196: 401-406.
15. Goldstein, J. D., R. S. Balderas, and G. Marodon. 2011. Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus. PLoS ONE 6: e19038.
16. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
17. + regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6: 1152-1159.
18. Grinberg-Bleyer, Y., A. Baeyens, S. You, R. Elhage, G. Fourcade, S. Gregoire, N. Cagnard, W. Carpentier, Q. Tang, J. Bluestone, et al. 2010. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J. Exp. Med. 207: 1871-1878.
19. + T regulatory cells. J. Immunol. 179: 154-161.
20. Hamano, R., J. Huang, T. Yoshimura, J. J. Oppenheim, and X. Chen. 2011. TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40. Eur. J. Immunol. 41: 2010-2020.
21. Yao, Z., Y. Kanno, M. Kerenyi, G. Stephens, L. Durant, W. T. Watford, A. Laurence, G. W. Robinson, E. M. Shevach, R. Moriggl, et al. 2007. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109: 4368-4375.
22. Ruby, C. E., M. A. Yates, D. Hirschhorn-Cymerman, P. Chlebeck, J. D. Wolchok, A. N. Houghton, H. Offner, and A. D. Weinberg. 2009. Cutting edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. J. Immunol. 183: 4853-4857.
23. Nohara, C., H. Akiba, A. Nakajima, A. Inoue, C. S. Koh, H. Ohshima, H. Yagita, Y. Mizuno, and K. Okumura. 2001. Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J. Immunol. 166: 2108-2115.
24. Croft, M. 2010. Control of immunity by the TNFR-related molecule OX40 (CD134). Annu. Rev. Immunol. 28: 57-78.
25. Ito, T., R. Amakawa, M. Inaba, T. Hori, M. Ota, K. Nakamura, M. Takebayashi, M. Miyaji, T. Yoshimura, K. Inaba, and S. Fukuhara. 2004. Plasmacytoid dendritic cells regulate Th cell responses through OX40 ligand and type I IFNs. J. Immunol. 172: 4253-4259.
26. Irla, M., N. Küpfer, T. Suter, R. Lissilaa, M. Benkhoucha, J. Skupsky, P. H. Lalive, A. Fontana, W. Reith, and S. Hugues. 2010. MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity. J. Exp. Med. 207: 1891-1905.
27. Ouabed, A., F. X. Hubert, D. Chabannes, L. Gautreau, M. Heslan, and R. Josien. 2008. Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacytoid versus conventional spleen dendritic cells. J. Immunol. 180: 5862-5870.
28. Jongbloed, S. L., R. A. Benson, M. B. Nickdel, P. Garside, I. B. McInnes, and J. M. Brewer. 2009. Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. J. Immunol. 182: 963-968.
29. Smigiel, K. S., E. Richards, S. Srivastava, K. R. Thomas, J. C. Dudda, K. D. Klonowski, and D. J. Campbell. 2014. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J. Exp. Med. 211: 121-136.
30. + regulatory T cells in vivo. Cytokine 65: 56-64.
31. Boyman, O., M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent. 2006. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311: 1924-1927.
32. Tang, Q., J. Y. Adams, C. Penaranda, K. Melli, E. Piaggio, E. Sgouroudis, C. A. Piccirillo, B. L. Salomon, and J. A. Bluestone. 2008. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28: 687-697.
33. Xiao, X., W. Gong, G. Demirci, W. Liu, S. Spoerl, X. Chu, D. K. Bishop, L. A. Turka, and X. C. Li. 2012. New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J. Immunol. 188: 892-901.
34. Griseri, T., M. Asquith, C. Thompson, and F. Powrie. 2010. OX40 is required for regulatory T cell-mediated control of colitis. J. Exp. Med. 207: 699-709.
35. Walker, L. S. 2009. Regulatory T cells overturned: the effectors fight back. Immunology 126: 466-474.
36. Ikeda, T., S. Hirata, S. Fukushima, Y. Matsunaga, T. Ito, M. Uchino, Y. Nishimura, and S. Senju. 2010. Dual effects of TRAIL in suppression of autoimmunity: the inhibition of Th1 cells and the promotion of regulatory T cells. J. Immunol. 185: 5259-5267.
37. Schreiber, T. H., D. Wolf, M. S. Tsai, J. Chirinos, V. V. Deyev, L. Gonzalez, T. R. Malek, R. B. Levy, and E. R. Podack. 2010. Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J. Clin. Invest. 120: 3629-3640.
38. + T cells. J. Immunol. 173: 5008-5020.
39. + regulatory T cells mediated by GITR molecules. Immunol. Lett. 121: 97-104.
40. Matta, B. M., A. Castellaneta, and A. W. Thomson. 2010. Tolerogenic plasmacytoid DC. Eur. J. Immunol. 40: 2667-2676.
41. + T-regulatory cells. Cancer Res. 72: 5240-5249.
42. + T cells. Cancer Res. 72: 6130-6141.
43. Sakaguchi, S., D. A. Vignali, A. Y. Rudensky, R. E. Niec, and H. Waldmann. 2013. The plasticity and stability of regulatory T cells. Nat. Rev. Immunol. 13: 461-467.
44. Miyara, M., Z. Amoura, C. Parizot, C. Badoual, K. Dorgham, S. Trad, M. Kambouchner, D. Valeyre, C. Chapelon-Abric, P. Debré, et al. 2006. The immune paradox of sarcoidosis and regulatory T cells. J. Exp. Med. 203: 359-370.
45. + regulatory cells within the central nervous system. J. Immunol. 175: 3025-3032.
46. Korn, T., J. Reddy, W. Gao, E. Bettelli, A. Awasthi, T. R. Petersen, B. T. Bäckström, R. A. Sobel, K. W. Wucherpfennig, T. B. Strom, et al. 2007. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat. Med. 13: 423-431.
47. Belkaid, Y., and K. Tarbell. 2009. Regulatory T cells in the control of hostmicroorganism interactions. Annu. Rev. Immunol. 27: 551-589.
48. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12: 431-440.
49. Zhang, R., A. Huynh, G. Whitcher, J. Chang, J. S. Maltzman, and L. A. Turka. 2013. An obligate cell-intrinsic function for CD28 in Tregs. J. Clin. Invest. 123: 580-593.