Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor

Toxicology

Volumn 329, Issue , 2015, Pages 10-20

  Roelofs, Maarke J E ^a,c   Berg, Martin van den ^a   Bovee, Toine F H ^b   Piersma, Aldert H ^a,c   Duursen, Majorie B M van ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

(Fetal like) steroidogenesis; (Structural) bisphenol analogues (TBBPA, BPA, BPF, BPS); Androgen receptor (AR); Glucocorticoid receptor (GR); Murine MA 10 Leydig cells; Testosterone (T)

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; BISPHENOL F; BISPHENOL S; ENDOCRINE DISRUPTOR; GESTAGEN; GLUCOCORTICOID RECEPTOR; PHENOL DERIVATIVE; STEROID HORMONE; TESTOSTERONE; TETRABROMOBISPHENOL A; UNCLASSIFIED DRUG; BENZHYDRYL DERIVATIVE; BIS(4-HYDROXYPHENYL)SULFONE; POLYBROMINATED BIPHENYL; SULFONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOCRINE FUNCTION; HORMONE RECEPTOR INTERACTION; HUMAN; IC50; IN VITRO STUDY; INHIBITION KINETICS; LEYDIG CELL; MA 10 CELL LINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; STEROID RELEASE; STEROIDOGENESIS; TESTIS FUNCTION; TESTOSTERONE SYNTHESIS; ANIMAL; BIOASSAY; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; SECRETION (PROCESS); TESTIS; YEAST;

MURINAE;

ANIMALS; BENZHYDRYL COMPOUNDS; BIOLOGICAL ASSAY; CELL SURVIVAL; CELLS, CULTURED; ENDOCRINE DISRUPTORS; GENE EXPRESSION; LEYDIG CELLS; MALE; MICE; PHENOLS; POLYBROMINATED BIPHENYLS; RECEPTORS, ANDROGEN; RECEPTORS, GLUCOCORTICOID; SULFONES; TESTIS; TESTOSTERONE; YEASTS;

EID: 84921528943     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2015.01.003     Document Type: Article

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