Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol

Toxicology Letters

Volumn 194, Issue 1-2, 2010, Pages 16-25

  Nakamura, Daichi ^a   Yanagiba, Yukie ^a   Duan, Zhiwen ^a   Ito, Yuki ^a   Okamura, Ai ^a   Asaeda, Nobuyuki ^b   Tagawa, Yoshiaki ^b   Li, ChunMei ^c,d   Taya, Kazuyoshi ^c,d   Zhang, Shu Yun ^a   Naito, Hisao ^a   Ramdhan, Doni Hikmat ^a   Kamijima, Michihiro ^a   Nakajima, Tamie ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Sana Kagaku Kenkyusho CoLtd   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

17 Estradiol; Bisphenol A; Leydig cells; Reproductive toxicity; Steroidogenesis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; AROMATASE; BENZODIAZEPINE RECEPTOR; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 17; CYTOCHROME P450 17ALPHA; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FOLLITROPIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LUTEINIZING HORMONE; MESSENGER RNA; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; UNCLASSIFIED DRUG; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; HYPOPHYSIS; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REPRODUCTIVE TOXICITY; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; TOXICITY TESTING; ANIMAL; BIOSYNTHESIS; BLOOD; BODY WEIGHT; DRUG EFFECT; METABOLISM; ORGAN SIZE; PATHOLOGY; WISTAR RAT;

RATTUS;

ANIMALS; AROMATASE; BODY WEIGHT; CHOLESTEROL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MALE; ORGAN SIZE; PHENOLS; PITUITARY GLAND; RATS; RATS, WISTAR; RNA, MESSENGER; TESTIS; TESTOSTERONE; TOXICITY TESTS;

EID: 77950476594     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.02.002     Document Type: Article

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