메뉴 건너뛰기




Volumn 110, Issue 24, 2013, Pages 9956-9961

Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol a exposure

Author keywords

Environmental; Fetal origin of adult disease

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

EID: 84878997362     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214056110     Document Type: Article
Times cited : (405)

References (51)
  • 2
    • 39749187628 scopus 로고    scopus 로고
    • Exposure of the U.S. population to bisphenol A and 4-tertiary- octylphenol: 2003-2004
    • Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008) Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 116(1):39-44.
    • (2008) Environ Health Perspect , vol.116 , Issue.1 , pp. 39-44
    • Calafat, A.M.1    Ye, X.2    Wong, L.Y.3    Reidy, J.A.4    Needham, L.L.5
  • 3
    • 79960223622 scopus 로고    scopus 로고
    • Epigenetic perspective on the developmental effects of bisphenol A
    • Kundakovic M, Champagne FA (2011) Epigenetic perspective on the developmental effects of bisphenol A. Brain Behav Immun 25(6):1084-1093.
    • (2011) Brain Behav Immun , vol.25 , Issue.6 , pp. 1084-1093
    • Kundakovic, M.1    Champagne, F.A.2
  • 5
    • 80355131121 scopus 로고    scopus 로고
    • Impact of early-life bisphenol A exposure on behavior and executive function in children
    • Braun JM, et al. (2011) Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics 128(5):873-882.
    • (2011) Pediatrics , vol.128 , Issue.5 , pp. 873-882
    • Braun, J.M.1
  • 6
    • 75349095250 scopus 로고    scopus 로고
    • Prenatal bisphenol A exposure and early childhood behavior
    • Braun JM, et al. (2009) Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect 117(12):1945-1952.
    • (2009) Environ Health Perspect , vol.117 , Issue.12 , pp. 1945-1952
    • Braun, J.M.1
  • 7
    • 84864763167 scopus 로고    scopus 로고
    • Prenatal bisphenol a exposure and child behavior in an innercity cohort
    • Perera F, et al. (2012) Prenatal bisphenol a exposure and child behavior in an innercity cohort. Environ Health Perspect 120(8):1190-1194.
    • (2012) Environ Health Perspect , vol.120 , Issue.8 , pp. 1190-1194
    • Perera, F.1
  • 9
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik W (2007) Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447(7143):425-432.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 425-432
    • Reik, W.1
  • 10
    • 44849092317 scopus 로고    scopus 로고
    • Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring
    • Novikova SI, et al. (2008) Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS One 3(4):e1919.
    • (2008) PLoS One , vol.3 , Issue.4
    • Novikova, S.I.1
  • 11
    • 54049086269 scopus 로고    scopus 로고
    • Sex-specific programming of offspring emotionality after stress early in pregnancy
    • Mueller BR, Bale TL (2008) Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci 28(36):9055-9065.
    • (2008) J Neurosci , vol.28 , Issue.36 , pp. 9055-9065
    • Mueller, B.R.1    Bale, T.L.2
  • 12
    • 56749170156 scopus 로고    scopus 로고
    • Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior
    • Skinner MK, Anway MD, Savenkova MI, Gore AC, Crews D (2008) Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior. PLoS ONE 3(11):e3745.
    • (2008) PLoS ONE , vol.3 , Issue.11
    • Skinner, M.K.1    Anway, M.D.2    Savenkova, M.I.3    Gore, A.C.4    Crews, D.5
  • 13
    • 77953090055 scopus 로고    scopus 로고
    • Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
    • Bromer JG, Zhou Y, Taylor MB, Doherty L, Taylor HS (2010) Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. FASEB J 24(7):2273-2280.
    • (2010) FASEB J , vol.24 , Issue.7 , pp. 2273-2280
    • Bromer, J.G.1    Zhou, Y.2    Taylor, M.B.3    Doherty, L.4    Taylor, H.S.5
  • 15
    • 80052737714 scopus 로고    scopus 로고
    • Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A
    • Doshi T, Mehta SS, Dighe V, Balasinor N, Vanage G (2011) Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A. Toxicology 289(2-3):74-82.
    • (2011) Toxicology , vol.289 , Issue.2-3 , pp. 74-82
    • Doshi, T.1    Mehta, S.S.2    Dighe, V.3    Balasinor, N.4    Vanage, G.5
  • 16
    • 33745246032 scopus 로고    scopus 로고
    • Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4
    • Ho SM, Tang WY, Belmonte de Frausto J, Prins GS (2006) Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 66(11):5624-5632.
    • (2006) Cancer Res , vol.66 , Issue.11 , pp. 5624-5632
    • Ho, S.M.1    Tang, W.Y.2    Belmonte De Frausto, J.3    Prins, G.S.4
  • 17
    • 84859984030 scopus 로고    scopus 로고
    • High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations
    • Jang YJ, et al. (2012) High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Toxicology 296(1-3):73-82.
    • (2012) Toxicology , vol.296 , Issue.1-3 , pp. 73-82
    • Jang, Y.J.1
  • 18
    • 53149087398 scopus 로고    scopus 로고
    • Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A
    • Yaoi T, et al. (2008) Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochem Biophys Res Commun 376(3):563-567.
    • (2008) Biochem Biophys Res Commun , vol.376 , Issue.3 , pp. 563-567
    • Yaoi, T.1
  • 19
    • 0035208142 scopus 로고    scopus 로고
    • Minireview: Genomic organization of the human ERalpha gene promoter region
    • DOI 10.1210/me.15.12.2057
    • Koš M, Reid G, Denger S, Gannon F (2001) Minireview: Genomic organization of the human ERalpha gene promoter region. Mol Endocrinol 15(12):2057-2063. (Pubitemid 33141126)
    • (2001) Molecular Endocrinology , vol.15 , Issue.12 , pp. 2057-2063
    • Kos, M.1    Reid, G.2    Denger, S.3    Gannon, F.4
  • 20
    • 74949100523 scopus 로고    scopus 로고
    • Epigenetic regulation of estrogen receptor alpha gene expression in the mouse cortex during early postnatal development
    • Westberry JM, Trout AL, Wilson ME (2010) Epigenetic regulation of estrogen receptor alpha gene expression in the mouse cortex during early postnatal development. Endocrinology 151(2):731-740.
    • (2010) Endocrinology , vol.151 , Issue.2 , pp. 731-740
    • Westberry, J.M.1    Trout, A.L.2    Wilson, M.E.3
  • 21
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, et al. (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 41(2):178-186.
    • (2009) Nat Genet , vol.41 , Issue.2 , pp. 178-186
    • Irizarry, R.A.1
  • 22
    • 0036082651 scopus 로고    scopus 로고
    • Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice
    • Palanza PL, Howdeshell KL, Parmigiani S, vom Saal FS (2002) Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice. Environ Health Perspect 110(suppl 3):415-422. (Pubitemid 34669809)
    • (2002) Environmental Health Perspectives , vol.110 , Issue.SUPPL. 3 , pp. 415-422
    • Palanza, P.1    Howdeshell, K.L.2    Parmigiani, S.3    Vom, S.F.S.4
  • 23
    • 77951452018 scopus 로고    scopus 로고
    • Epigenetic influence of social experiences across the lifespan
    • Champagne FA (2010) Epigenetic influence of social experiences across the lifespan. Dev Psychobiol 52(4):299-311.
    • (2010) Dev Psychobiol , vol.52 , Issue.4 , pp. 299-311
    • Champagne, F.A.1
  • 24
    • 0034928759 scopus 로고    scopus 로고
    • Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    • Meaney MJ (2001) Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci 24:1161-1192.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 1161-1192
    • Meaney, M.J.1
  • 25
    • 84859373425 scopus 로고    scopus 로고
    • Hormones and endocrine-disrupting chemicals: Lowdose effects and nonmonotonic dose responses
    • Vandenberg LN, et al. (2012) Hormones and endocrine-disrupting chemicals: Lowdose effects and nonmonotonic dose responses. Endocr Rev 33(3):378-455.
    • (2012) Endocr Rev , vol.33 , Issue.3 , pp. 378-455
    • Vandenberg, L.N.1
  • 26
    • 57649197340 scopus 로고
    • Integrated Risk Information System. Available at Accessed July 4, 2012
    • US Environmental Protection Agency (1988) Bisphenol A (CASRN 80-05-7). Integrated Risk Information System. Available at www.epa.gov/iris/subst/0356. htm. Accessed July 4, 2012.
    • (1988) Bisphenol A (CASRN 80-05-7)
  • 27
    • 60549106214 scopus 로고    scopus 로고
    • Bisphenol-A and the great divide: A review of controversies in the field of endocrine disruption
    • Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM (2009) Bisphenol-A and the great divide: A review of controversies in the field of endocrine disruption. Endocr Rev 30(1):75-95.
    • (2009) Endocr Rev , vol.30 , Issue.1 , pp. 75-95
    • Vandenberg, L.N.1    Maffini, M.V.2    Sonnenschein, C.3    Rubin, B.S.4    Soto, A.M.5
  • 28
    • 0036078646 scopus 로고    scopus 로고
    • Effects of perinatal exposure to bisphenol A on play behavior of female and male juvenile rats
    • Dessì-Fulgheri F, Porrini S, Farabollini F (2002) Effects of perinatal exposure to bisphenol A on play behavior of female and male juvenile rats. Environ Health Perspect 110(suppl 3):403-407. (Pubitemid 34661948)
    • (2002) Environmental Health Perspectives , vol.110 , Issue.SUPPL. 3 , pp. 403-407
    • Dessi-Fulgheri, F.1    Porrini, S.2    Farabollini, F.3
  • 29
    • 0037333736 scopus 로고    scopus 로고
    • Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats
    • DOI 10.1016/S0168-0102(02)00251-1
    • Kubo K, et al. (2003) Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. Neurosci Res 45(3):345-356. (Pubitemid 36298817)
    • (2003) Neuroscience Research , vol.45 , Issue.3 , pp. 345-356
    • Kubo, K.1    Arai, O.2    Omura, M.3    Watanabe, R.4    Ogata, R.5    Aou, S.6
  • 30
    • 32944481234 scopus 로고    scopus 로고
    • Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV
    • DOI 10.1016/j.ntt.2005.11.004, PII S0892036205001765
    • Patisaul HB, Fortino AE, Polston EK (2006) Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV. Neurotoxicol Teratol 28(1):111-118. (Pubitemid 43256703)
    • (2006) Neurotoxicology and Teratology , vol.28 , Issue.1 , pp. 111-118
    • Patisaul, H.B.1    Fortino, A.E.2    Polston, E.K.3
  • 31
    • 33746082816 scopus 로고    scopus 로고
    • Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A
    • DOI 10.1210/en.2006-0189
    • Rubin BS, et al. (2006) Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A. Endocrinology 147(8):3681-3691. (Pubitemid 44079373)
    • (2006) Endocrinology , vol.147 , Issue.8 , pp. 3681-3691
    • Rubin, B.S.1    Lenkowski, J.R.2    Schaeberle, C.M.3    Vandenberg, L.N.4    Ronsheim, P.M.5    Soto, A.M.6
  • 32
    • 84856453549 scopus 로고    scopus 로고
    • Neonatal bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus
    • Cao J, Mickens JA, McCaffrey KA, Leyrer SM, Patisaul HB (2012) Neonatal bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus. Neurotoxicology 33(1):23-36.
    • (2012) Neurotoxicology , vol.33 , Issue.1 , pp. 23-36
    • Cao, J.1    Mickens, J.A.2    McCaffrey, K.A.3    Leyrer, S.M.4    Patisaul, H.B.5
  • 33
    • 0034522699 scopus 로고    scopus 로고
    • Exposure of newborn male and female rats to environmental estrogens: Delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression
    • DOI 10.1210/en.141.12.4512
    • Khurana S, Ranmal S, Ben-Jonathan N (2000) Exposure of newborn male and female rats to environmental estrogens: Delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression. Endocrinology 141(12):4512-4517. (Pubitemid 32055128)
    • (2000) Endocrinology , vol.141 , Issue.12 , pp. 4512-4517
    • Khurana, S.1    Ranmal, S.2    Ben-Jonathan, N.3
  • 34
    • 78649461891 scopus 로고    scopus 로고
    • Exposure of neonatal female rats to bisphenol A disrupts hypothalamic LHRH pre-mRNA processing and estrogen receptor alpha expression in nuclei controlling estrous cyclicity
    • Monje L, Varayoud J, Muñoz-de-Toro M, Luque EH, Ramos JG (2010) Exposure of neonatal female rats to bisphenol A disrupts hypothalamic LHRH pre-mRNA processing and estrogen receptor alpha expression in nuclei controlling estrous cyclicity. Reprod Toxicol 30(4):625-634.
    • (2010) Reprod Toxicol , vol.30 , Issue.4 , pp. 625-634
    • Monje, L.1    Varayoud, J.2    Muñoz-de-Toro, M.3    Luque, E.H.4    Ramos, J.G.5
  • 35
    • 84055197915 scopus 로고    scopus 로고
    • Roles for oestrogen receptor β in adult brain function
    • Handa RJ, Ogawa S, Wang JM, Herbison AE (2012) Roles for oestrogen receptor β in adult brain function. J Neuroendocrinol 24(1):160-173.
    • (2012) J Neuroendocrinol , vol.24 , Issue.1 , pp. 160-173
    • Handa, R.J.1    Ogawa, S.2    Wang, J.M.3    Herbison, A.E.4
  • 36
    • 79960816743 scopus 로고    scopus 로고
    • Reframing sexual differentiation of the brain
    • McCarthy MM, Arnold AP (2011) Reframing sexual differentiation of the brain. Nat Neurosci 14(6):677-683.
    • (2011) Nat Neurosci , vol.14 , Issue.6 , pp. 677-683
    • McCarthy, M.M.1    Arnold, A.P.2
  • 37
    • 77956180415 scopus 로고    scopus 로고
    • Contributions of estrogen receptor-α and estrogen receptor-β to the regulation of behavior
    • Tetel MJ, Pfaff DW (2010) Contributions of estrogen receptor-α and estrogen receptor-β to the regulation of behavior. Biochim Biophys Acta 1800(10):1084-1089.
    • (2010) Biochim Biophys Acta , vol.1800 , Issue.10 , pp. 1084-1089
    • Tetel, M.J.1    Pfaff, D.W.2
  • 38
    • 0343776953 scopus 로고    scopus 로고
    • Differential expression of the estrogen receptor-related receptor gamma in the mouse brain
    • DOI 10.1016/S0169-328X(00)00063-2, PII S0169328X00000632
    • Lorke DE, Süsens U, Borgmeyer U, Hermans-Borgmeyer I (2000) Differential expression of the estrogen receptor-related receptor gamma in the mouse brain. Brain Res Mol Brain Res 77(2):277-280. (Pubitemid 30317355)
    • (2000) Molecular Brain Research , vol.77 , Issue.2 , pp. 277-280
    • Lorke, D.E.1    Susens, U.2    Borgmeyer, U.3    Hermans-Borgmeyer, I.4
  • 39
    • 33646784653 scopus 로고    scopus 로고
    • Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring
    • DOI 10.1210/en.2005-1119
    • Champagne FA, et al. (2006) Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology 147(6):2909-2915. (Pubitemid 43764626)
    • (2006) Endocrinology , vol.147 , Issue.6 , pp. 2909-2915
    • Champagne, F.A.1    Weaver, I.C.G.2    Diorio, J.3    Dymov, S.4    Szyf, M.5    Meaney, M.J.6
  • 40
    • 77957277418 scopus 로고    scopus 로고
    • Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span
    • Schwarz JM, Nugent BM, McCarthy MM (2010) Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span. Endocrinology 151(10):4871-4881.
    • (2010) Endocrinology , vol.151 , Issue.10 , pp. 4871-4881
    • Schwarz, J.M.1    Nugent, B.M.2    McCarthy, M.M.3
  • 41
    • 77953168537 scopus 로고    scopus 로고
    • Sex differences in epigenetic regulation of the estrogen receptor-α promoter within the developing preoptic area
    • Kurian JR, Olesen KM, Auger AP (2010) Sex differences in epigenetic regulation of the estrogen receptor-α promoter within the developing preoptic area. Endocrinology 151(5):2297-2305.
    • (2010) Endocrinology , vol.151 , Issue.5 , pp. 2297-2305
    • Kurian, J.R.1    Olesen, K.M.2    Auger, A.P.3
  • 42
    • 16444381345 scopus 로고    scopus 로고
    • Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system
    • DOI 10.1002/jnr.20404
    • Feng J, Chang H, Li E, Fan G (2005) Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res 79(6):734-746. (Pubitemid 40476498)
    • (2005) Journal of Neuroscience Research , vol.79 , Issue.6 , pp. 734-746
    • Feng, J.1    Chang, H.2    Li, E.3    Fan, G.4
  • 43
    • 0028267714 scopus 로고
    • Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice
    • Goto K, et al. (1994) Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice. Differentiation 56(1-2):39-44. (Pubitemid 24102005)
    • (1994) Differentiation , vol.56 , Issue.1-2 , pp. 39-44
    • Goto, K.1    Numata, M.2    Komura, J.-I.3    Ono, T.4    Bestor, T.H.5    Kondo, H.6
  • 44
    • 77950187447 scopus 로고    scopus 로고
    • Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    • Feng J, et al. (2010) Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci 13(4):423-430.
    • (2010) Nat Neurosci , vol.13 , Issue.4 , pp. 423-430
    • Feng, J.1
  • 45
    • 77956139754 scopus 로고    scopus 로고
    • Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    • LaPlant Q, et al. (2010) Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci 13(9):1137-1143.
    • (2010) Nat Neurosci , vol.13 , Issue.9 , pp. 1137-1143
    • LaPlant, Q.1
  • 46
    • 80053240801 scopus 로고    scopus 로고
    • Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice
    • Wolstenholme JT, et al. (2011) Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice. PLoS ONE 6(9):e25448.
    • (2011) PLoS ONE , vol.6 , Issue.9
    • Wolstenholme, J.T.1
  • 47
    • 84864387145 scopus 로고    scopus 로고
    • Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression
    • Wolstenholme JT, et al. (2012) Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology 153(8):3828-3838.
    • (2012) Endocrinology , vol.153 , Issue.8 , pp. 3828-3838
    • Wolstenholme, J.T.1
  • 48
    • 12344334398 scopus 로고    scopus 로고
    • Novel actions of estrogen receptor-beta on anxiety-related behaviors
    • DOI 10.1210/en.2004-1158
    • Lund TD, Rovis T, Chung WC, Handa RJ (2005) Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology 146(2):797-807. (Pubitemid 40129837)
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 797-807
    • Lund, T.D.1    Rovis, T.2    Chung, W.C.J.3    Handa, R.J.4
  • 49
    • 12144263826 scopus 로고    scopus 로고
    • Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice
    • DOI 10.1016/j.physbeh.2004.11.002, PII S0031938404004731
    • Imwalle DB, Gustafsson JA, Rissman EF (2005) Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Physiol Behav 84(1):157-163. (Pubitemid 40103501)
    • (2005) Physiology and Behavior , vol.84 , Issue.1 , pp. 157-163
    • Imwalle, D.B.1    Gustafsson, J.-A.2    Rissman, E.F.3
  • 50
    • 0031724077 scopus 로고    scopus 로고
    • Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice
    • Ogawa S, et al. (1998) Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice. Endocrinology 139(12):5070-5081. (Pubitemid 28533455)
    • (1998) Endocrinology , vol.139 , Issue.12 , pp. 5070-5081
    • Ogawa, S.1    Eng, V.2    Taylor, J.3    Lubahn, D.B.4    Korach, K.S.5    Pfaff, D.W.6
  • 51
    • 70350433239 scopus 로고    scopus 로고
    • The epigenetics of sex differences in the brain
    • McCarthy MM, et al. (2009) The epigenetics of sex differences in the brain. J Neurosci 29(41):12815-12823.
    • (2009) J Neurosci , vol.29 , Issue.41 , pp. 12815-12823
    • McCarthy, M.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.