Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways

European Journal of Pharmacology

Volumn 749, Issue , 2015, Pages 39-48

  Lee, Da Hee ^a   Nam, Yoon Jeong ^a   Lee, Min Sung ^b   Sohn, Dong Suep ^c   Lee, Chung Soo ^a  

^a Chung Ang University   (South Korea)

^b Soonchunhyang University College of Medicine   (South Korea)

^c Chung Ang University College of Medicine   (South Korea)

Author keywords

Apoptosis related proteins; Cholesterol oxidation product; PC12 cells; Protection; Rotundarpene

Indexed keywords

25 HYDROXYCHOLESTEROL; 7 OXOCHOLESTEROL; ANTIOXIDANT; APOPTOSIS RELATED PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; GLUTATHIONE; MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P53; ROTUNDARPENE; SURVIVIN; UNCLASSIFIED DRUG; 7-KETOCHOLESTEROL; BID PROTEIN, RAT; CAFFEIC ACID DERIVATIVE; CASP8 PROTEIN, RAT; CHOLESTEROL; CHOLESTEROL DERIVATIVE; CYTOCHROME C; HEMITERPENE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CELL DAMAGE; CELL LEVEL; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MITOCHONDRIAL DYNAMICS; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; APOPTOSIS; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; MITOCHONDRION; NERVE CELL; OXIDATION REDUCTION REACTION; PC12 CELL LINE;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CAFFEIC ACIDS; CASPASE 8; CELL SURVIVAL; CHOLESTEROL; CYTOCHROMES C; GLUTATHIONE; HEMITERPENES; KETOCHOLESTEROLS; MITOCHONDRIA; NEURONS; OXIDATION-REDUCTION; PC12 CELLS; RATS;

EID: 84921513819     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.11.048     Document Type: Article

References (42)

1. V. Andrisano, R. Ballardini, P. Hrelia, N. Cameli, A. Tosti, R. Gotti, and V. Cavrini Studies on the photostability and in vitro phototoxicity of Labetalol Eur. J. Pharm. Sci. 12 2001 495 504
2. J.S. Armstrong Mitochondria: a target for cancer therapy Br. J. Pharmacol. 147 2006 239 248
3. A. Berthier, S. Lemaire-Ewing, C. Prunet, S. Monier, A. Athias, G. Bessède, J.P. Pais de Barros, A. Laubriet, P. Gambert, G. Lizard, and D. Néel Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis Cell Death Differ. 11 2004 897 905
4. I. Bjorkhem, M. Heverin, V. Leoni, S. Meany, and U. Diczfalusy Oxysetrols and Alzheimers disease Acta Neurol. Scand. Suppl. 185 2006 43 49
5. U. Bonuccelli, and P. Del Dotto New pharmacological horizons in the treatment of Parkinson disease Neurology 67 7 Suppl 2 2006 S30 S38
6. A. Camins, M. Pallas, and J.S. Silvestre Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches Methods Find Exp. Clin. Pharmacol. 30 2008 43 65
7. J. Chandra, A. Samali, and S. Orrenius Triggering and modulation of apoptosis by oxidative stress Free Radic. Biol. Med. 29 2000 323 333
8. F. Chen, W. Wang, and W.S. El-Deiry Current strategies to target p53 in cancer Biochem. Pharmacol. 80 2010 724 730
9. J.E. Chipuk, and D.R. Green Dissecting p53-dependent apoptosis Cell Death Differ. 13 2006 994 1002
10. J. Choi, K.M. Shin, H.J. Park, H.J. Jung, H.J. Kim, Y.S. Lee, J.H. Rew, and K.T. Lee Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin Planta Med. 70 2004 1027 1032
11. M.L. Circu, and T.Y. Aw Glutathione and apoptosis Free Radic. Res. 42 2008 689 706
12. P. Decker, and S. Muller Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress Curr. Pharm. Biotechnol. 3 2002 275 283
13. R. Franco, and J.A. Cidlowski Apoptosis and glutathione: beyond an antioxidant Cell Death Differ 16 2009 1303 1314
14. W. Fu, H. Luo, S. Parthasarathy, and M.P. Mattson Catecholamines potentiate amyloid β-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis Neurobiol. Dis. 5 1998 229 243
15. W. Hu, and J.J. Kavanagh Anticancer therapy targeting the apoptotic pathway Lancet Oncol. 4 2003 721 729
16. J. Jiang, S. Xu, and Y. Kong Pharmacological studies of trilex on treatment of pharyngitis Zhong Yao Cai 23 2000 630 632
17. T.T. Jiang, R.W. Zhang, and Q.Y. Fan Progress on study of Ilex Rotunda thumb Guid. J. TCM 13 2007 111 114
18. Z. Jin, and W.S. El-Deiry Overview of cell death signaling pathways Cancer Biol. Ther. 4 2005 139 163
19. Y.J. Kim, E.B. Jung, M.S. Lee, S.J. Seo, M.H. Kim, M.W. Lee, and C.S. Lee Rotundarpene inhibits Toll-like receptor 2 activation-induced production of inflammatory mediators in keratinocytes by suppressing the Akt and NF-κB pathways Int. Immunopharmacol. 18 2014 325 332
20. S.S. Kim, R.Y. Park, H.J. Jeon, Y.S. Kwon, and W. Chun Neuroprotective effects of 3,5-dicaffeoylquinic acid on hydrogen peroxide-induced cell death in SH-SY5Y cells Phytother. Res. 19 2005 243 245
21. M.H. Kim, K.H. Park, M.H. Oh, H.H. Kim, K.I. Choe, S.H. Park, and M.W. Lee Two new hemiterpene glycosides from the leaves of Ilex rotunda. Thunb. Arch Pharm. Res. 35 2012 1779 1784
22. C.S. Lee, S.A. Lee, Y.J. Kim, S.J. Seo, and M.W. Lee 3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways Int. Immunopharmacol. 11 2011 1715 1723
23. S. Lemaire-Ewing, C. Prunet, T. Montange, A. Vejux, A. Berthier, G. Bessede, L. Corcos, P. Gambert, D. Néel, and G. Lizard Comparison of the cytotoxic, prooxidant and pro-inflammatory characteristics of different oxysterols Cell Biol. Toxicol. 21 2005 97 114
24. V. Leoni, and C. Caccia Oxysterols as biomarkers in neurodegenerative diseases Chem. Phys. Lipids. 164 2011 515 524
25. C. Li, Y. Li, C. Yao, and W. Wang Free radical scavenging activity of extract from Ilex rotunda determined by electron spin resonance spectroscopy J. Med. Plants Res. 6 2012 2224 2229
26. S. Lordan, J.J. Mackrill, and N.M. OBrien Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases J. Nutr. Biochem. 20 2009 321 336
27. B. Mignotte, and J.L. Vayssière Mitochondria and apoptosis Eur. J. Biochem. 252 1998 1 15
28. C. Miguet-Alfonsi, C. Prunet, S. Monier, G. Bessède, S. Lemaire-Ewing, A. Berthier, F. Mènètrier, D. Nèel, P. Gambert, and G. Lizard Analysis of oxidative processes and of myelin figures formation before and after the loss of the mitochondrial transmembrane potential during 7β-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals Biochem. Pharmacol. 64 2002 527 541
29. F. Misiti, F. Orsini, M.E. Clementi, W. Lattanzi, B. Giardina, and F. Michetti Mitochondrial oxygen consumption inhibition importance for TMT-dependent cell death in undifferentiated PC12 cells Neurochem. Int. 52 2008 1092 1099
30. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
31. T.J. Nelson, and D.L. Alkon Oxidation of cholesterol by amyloid precursor protein and β-amyloid peptide J. Biol. Chem. 280 2005 7377 7387
32. M. Ott, V. Gogvadze, S. Orrenius, and B. Zhivotovsky Mitochondria, oxidative stress and cell death Apoptosis 12 2007 913 922
33. M. Ott, E. Norberg, B. Zhivotovsky, and S. Orrenius Mitochondrial targeting of tBid/Bax: a role for the TOM complex? Cell Death Differ. 16 2009 1075 1082
34. K.H. Park, M. Park, S.E. Choi, M.S. Jeong, J.H. Kwon, M.H. Oh, S.J. Seo, and M.W. Lee The anti-oxidative and anti-inflammatory effects of caffeoyl derivatives from the roots of Aconitum koreanum R. RAYMOND Biol. Pham. Bull. 32 2009 2029 2033
35. G. Poli, F. Biasi, and G. Leonarduzzi Oxysterols in the pathogenesis of major chronic diseases Redox Biol. 1 2013 125 130
36. M. Ramalingam, and S.J. Kim Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases J. Neural. Transm. 119 2012 891 910
37. R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990 s Nature 362 1993 801 809
38. E.K. Rydberg, L. Salomonsson, L.M. Hulten, K. Noren, G. Bondjers, O. Wiklund, T. Björnheden, and B.G. Ohlsson Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages Atherosclerosis 170 2003 245 252
39. W.G. Tatton, R.M.E. Chalmers-Redman, W.J.H. Ju, M. Mammen, G.W. Carlile, A.W. Pong, and N.A. Tatton Propargylamines induce antiapoptotic new protein synthesis in serum-and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells J. Pharmacol. Exp. Ther. 301 2002 753 764
40. R.J. van Klaveren, P.H.M. Hoet, J.L. Pype, M. Demedts, and B. Nemery Increase in γ-glutamyltransferase by glutathione depletion in rat type II pneumocytes Free Radic. Biol. Med. 22 1997 525 534
41. A. Vejux, L. Malvitte, and G. Lizard Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis Braz. J. Med. Biol. Res. 41 2008 545 556
42. L.C. Zhao, Y. He, X. Deng, X.H. Xia, J. Liang, G.L. Yang, W. Li, and H. Wang Ultrasound-Assisted Extraction of Syringin from the Bark of Ilex rotunda Thumb Using Response Surface Methodology Int. J. Mol. Sci. 13 2012 7607 7616