Rotundarpene inhibits Toll-like receptor 2 activation-induced production of inflammatory mediators in keratinocytes by suppressing the Akt and NF-κB pathways

International Immunopharmacology

Volumn 18, Issue 2, 2014, Pages 325-332

  Kim, Yun Jeong ^a   Jung, Eun Byul ^a   Lee, Min Sung ^b   Seo, Seong Jun ^c   Kim, Manh Heun ^a   Lee, Min Won ^a   Lee, Chung Soo ^a  

^a Chung Ang University   (South Korea)

^b Soonchunhyang University College of Medicine   (South Korea)

^c Chung Ang University College of Medicine   (South Korea)

Author keywords

Akt and NF B pathways; Inflammatory mediator production; Keratinocytes; Microbial components; Rotundarpene; Toll like receptor 2

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLCYSTEINE; ANTIINFLAMMATORY AGENT; CUTANEOUS T CELL ATTRACTING CHEMOKINE; CYCLOSPORIN A; HEMITERPENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOTEICHOIC ACID; PEPTIDOGLYCAN; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; REACTIVE OXYGEN METABOLITE; ROTUNDARPENE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE RESPONSE; INFLAMMATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SKIN DISEASE; WESTERN BLOTTING;

AKT AND NF-ΚB PATHWAYS; INFLAMMATORY MEDIATOR PRODUCTION; KERATINOCYTES; MICROBIAL COMPONENTS; ROTUNDARPENE; TOLL-LIKE RECEPTOR-2;

ANTI-INFLAMMATORY AGENTS; CAFFEIC ACIDS; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DINOPROSTONE; HEMITERPENES; HUMANS; ILEX; KERATINOCYTES; LIPOPOLYSACCHARIDES; NF-KAPPA B; PLANT BARK; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2;

EID: 84891888293     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.12.016     Document Type: Article

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